Assessment of glucose kinetics with real-time continuous glucose monitoring during labor

Research output: Contribution to journalArticle

Abstract

Aim: Changes in glucose levels during labor have not been sufficiently investigated in pregnant women. Using real-time continuous glucose monitoring, we aimed to assess glucose kinetics during labor among pregnant women with gestational diabetes mellitus (PwGDM), and those with normal glucose tolerance (PwNGT). Methods: Japanese PwGDM and PwNGT who had planned a transvaginal delivery at Okayama University Hospital were enrolled. The correlation between changes in glucose levels during labor among the PwGDM and PwNGT groups at four time periods was assessed: (i) active phase of 1st stage of labor; (ii) 2nd stage of labor; (iii) postpartum 0–12 h; and (iv) postpartum 12–48 h. Results: In total, 18 and 22 PwGDM and PwNGT, respectively, were enrolled. During labor, both groups had similar changes in glucose levels over time, which peaked during period 3. The main effect of glucose level changes was the labor period (P < 0.001), not the presence of gestational diabetes mellitus. Furthermore, differences in glucose levels in the PwGDM group were observed between periods 1 and 2 (P = 0.037), 1 and 3 (P = 0.024), 3 and 4 (P = 0.005); differences in glucose levels in the PwNGT group were observed between periods 3 and 4 (P = 0.024). Conclusion: During labor, both PwGDM and PwNGT groups showed similar changes in glucose levels over time. During delivery, the PwGDM who regularly measured their own glucose levels could be managed using the same nutritional management methods as those for PwNGT.

Original languageEnglish
JournalJournal of Obstetrics and Gynaecology Research
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Glucose
Gestational Diabetes
Pregnant Women
Postpartum Period

Keywords

  • continuous glucose monitoring
  • during labor
  • gestational diabetes mellitus
  • glucose level
  • pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

@article{7ca7a19e8d5b451b94ac5032f63ca431,
title = "Assessment of glucose kinetics with real-time continuous glucose monitoring during labor",
abstract = "Aim: Changes in glucose levels during labor have not been sufficiently investigated in pregnant women. Using real-time continuous glucose monitoring, we aimed to assess glucose kinetics during labor among pregnant women with gestational diabetes mellitus (PwGDM), and those with normal glucose tolerance (PwNGT). Methods: Japanese PwGDM and PwNGT who had planned a transvaginal delivery at Okayama University Hospital were enrolled. The correlation between changes in glucose levels during labor among the PwGDM and PwNGT groups at four time periods was assessed: (i) active phase of 1st stage of labor; (ii) 2nd stage of labor; (iii) postpartum 0–12 h; and (iv) postpartum 12–48 h. Results: In total, 18 and 22 PwGDM and PwNGT, respectively, were enrolled. During labor, both groups had similar changes in glucose levels over time, which peaked during period 3. The main effect of glucose level changes was the labor period (P < 0.001), not the presence of gestational diabetes mellitus. Furthermore, differences in glucose levels in the PwGDM group were observed between periods 1 and 2 (P = 0.037), 1 and 3 (P = 0.024), 3 and 4 (P = 0.005); differences in glucose levels in the PwNGT group were observed between periods 3 and 4 (P = 0.024). Conclusion: During labor, both PwGDM and PwNGT groups showed similar changes in glucose levels over time. During delivery, the PwGDM who regularly measured their own glucose levels could be managed using the same nutritional management methods as those for PwNGT.",
keywords = "continuous glucose monitoring, during labor, gestational diabetes mellitus, glucose level, pregnancy",
author = "Jota Maki and Eriko Eto and Shoko Tamada and Takashi Mitsui and Kei Hayata and Keiichiro Nakamura and Yuji Hiramatsu and Hisashi Masuyama",
year = "2019",
month = "1",
day = "1",
doi = "10.1111/jog.14058",
language = "English",
journal = "Journal of Obstetrics and Gynaecology Research",
issn = "1341-8076",
publisher = "Blackwell Publishing Asia",

}

TY - JOUR

T1 - Assessment of glucose kinetics with real-time continuous glucose monitoring during labor

AU - Maki, Jota

AU - Eto, Eriko

AU - Tamada, Shoko

AU - Mitsui, Takashi

AU - Hayata, Kei

AU - Nakamura, Keiichiro

AU - Hiramatsu, Yuji

AU - Masuyama, Hisashi

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Aim: Changes in glucose levels during labor have not been sufficiently investigated in pregnant women. Using real-time continuous glucose monitoring, we aimed to assess glucose kinetics during labor among pregnant women with gestational diabetes mellitus (PwGDM), and those with normal glucose tolerance (PwNGT). Methods: Japanese PwGDM and PwNGT who had planned a transvaginal delivery at Okayama University Hospital were enrolled. The correlation between changes in glucose levels during labor among the PwGDM and PwNGT groups at four time periods was assessed: (i) active phase of 1st stage of labor; (ii) 2nd stage of labor; (iii) postpartum 0–12 h; and (iv) postpartum 12–48 h. Results: In total, 18 and 22 PwGDM and PwNGT, respectively, were enrolled. During labor, both groups had similar changes in glucose levels over time, which peaked during period 3. The main effect of glucose level changes was the labor period (P < 0.001), not the presence of gestational diabetes mellitus. Furthermore, differences in glucose levels in the PwGDM group were observed between periods 1 and 2 (P = 0.037), 1 and 3 (P = 0.024), 3 and 4 (P = 0.005); differences in glucose levels in the PwNGT group were observed between periods 3 and 4 (P = 0.024). Conclusion: During labor, both PwGDM and PwNGT groups showed similar changes in glucose levels over time. During delivery, the PwGDM who regularly measured their own glucose levels could be managed using the same nutritional management methods as those for PwNGT.

AB - Aim: Changes in glucose levels during labor have not been sufficiently investigated in pregnant women. Using real-time continuous glucose monitoring, we aimed to assess glucose kinetics during labor among pregnant women with gestational diabetes mellitus (PwGDM), and those with normal glucose tolerance (PwNGT). Methods: Japanese PwGDM and PwNGT who had planned a transvaginal delivery at Okayama University Hospital were enrolled. The correlation between changes in glucose levels during labor among the PwGDM and PwNGT groups at four time periods was assessed: (i) active phase of 1st stage of labor; (ii) 2nd stage of labor; (iii) postpartum 0–12 h; and (iv) postpartum 12–48 h. Results: In total, 18 and 22 PwGDM and PwNGT, respectively, were enrolled. During labor, both groups had similar changes in glucose levels over time, which peaked during period 3. The main effect of glucose level changes was the labor period (P < 0.001), not the presence of gestational diabetes mellitus. Furthermore, differences in glucose levels in the PwGDM group were observed between periods 1 and 2 (P = 0.037), 1 and 3 (P = 0.024), 3 and 4 (P = 0.005); differences in glucose levels in the PwNGT group were observed between periods 3 and 4 (P = 0.024). Conclusion: During labor, both PwGDM and PwNGT groups showed similar changes in glucose levels over time. During delivery, the PwGDM who regularly measured their own glucose levels could be managed using the same nutritional management methods as those for PwNGT.

KW - continuous glucose monitoring

KW - during labor

KW - gestational diabetes mellitus

KW - glucose level

KW - pregnancy

UR - http://www.scopus.com/inward/record.url?scp=85069819379&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85069819379&partnerID=8YFLogxK

U2 - 10.1111/jog.14058

DO - 10.1111/jog.14058

M3 - Article

C2 - 31321843

AN - SCOPUS:85069819379

JO - Journal of Obstetrics and Gynaecology Research

JF - Journal of Obstetrics and Gynaecology Research

SN - 1341-8076

ER -