Assessment of endogenous nitric oxide formation in newborns

Measurement of urinary nitrite and nitrate concentrations

Hirokazu Tsukahara, Motohiro Takeuchi, Ikue Hata, Masahiro Hiraoka, Fumikazu Kotsuji, Masakatsu Sudo, Mitsufumi Mayumi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We measured the urinary nitrite and nitrate (NO(X)-) excretion, an index of endogenous nitric oxide formation, in term and preterm newborns on the 1st and 4th days of age. In the infants of both groups, the urinary NO(X)- excretion significantly increased from the 1st to the 4th day. The urinary NO(X)- excretion in preterm infants was significantly higher as compared with term babies on both days. Furthermore, the urinary NO(X)- excretion was significantly elevated in preterm infants with respiratory distress syndrome as compared with those without cardiopulmonary complications on the 4th day. These changes of urinary NO(X)- excretion in newborns strongly suggest the presence of an active physiological role for nitric oxide in the circulatory adaptation to extrauterine life.

Original languageEnglish
Pages (from-to)322-326
Number of pages5
JournalBiology of the Neonate
Volume72
Issue number5
Publication statusPublished - Nov 1997
Externally publishedYes

Fingerprint

Nitrites
Premature Infants
Nitrates
Nitric Oxide
Newborn Infant
Newborn Respiratory Distress Syndrome

Keywords

  • Newborns
  • Nitric oxide
  • Respiratory distress syndrome
  • Urinary nitrate
  • Urinary nitrite

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Cite this

Tsukahara, H., Takeuchi, M., Hata, I., Hiraoka, M., Kotsuji, F., Sudo, M., & Mayumi, M. (1997). Assessment of endogenous nitric oxide formation in newborns: Measurement of urinary nitrite and nitrate concentrations. Biology of the Neonate, 72(5), 322-326.

Assessment of endogenous nitric oxide formation in newborns : Measurement of urinary nitrite and nitrate concentrations. / Tsukahara, Hirokazu; Takeuchi, Motohiro; Hata, Ikue; Hiraoka, Masahiro; Kotsuji, Fumikazu; Sudo, Masakatsu; Mayumi, Mitsufumi.

In: Biology of the Neonate, Vol. 72, No. 5, 11.1997, p. 322-326.

Research output: Contribution to journalArticle

Tsukahara, H, Takeuchi, M, Hata, I, Hiraoka, M, Kotsuji, F, Sudo, M & Mayumi, M 1997, 'Assessment of endogenous nitric oxide formation in newborns: Measurement of urinary nitrite and nitrate concentrations', Biology of the Neonate, vol. 72, no. 5, pp. 322-326.
Tsukahara, Hirokazu ; Takeuchi, Motohiro ; Hata, Ikue ; Hiraoka, Masahiro ; Kotsuji, Fumikazu ; Sudo, Masakatsu ; Mayumi, Mitsufumi. / Assessment of endogenous nitric oxide formation in newborns : Measurement of urinary nitrite and nitrate concentrations. In: Biology of the Neonate. 1997 ; Vol. 72, No. 5. pp. 322-326.
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