Assessment of Endogenous Nitric Oxide Formation in Newborns: Measurement of Urinary Nitrite and Nitrate Concentrations

Hirokazu Tsukahara; Motohiro Takeuchi; Ikue Hata; Masahiro Hiraoka; Fumikazu Kotsuji; Masakatsu Sudo; Mitsufumi Mayumi

doi:10.1159/000244499

Assessment of Endogenous Nitric Oxide Formation in Newborns: Measurement of Urinary Nitrite and Nitrate Concentrations

Hirokazu Tsukahara, Motohiro Takeuchi, Ikue Hata, Masahiro Hiraoka, Fumikazu Kotsuji, Masakatsu Sudo, Mitsufumi Mayumi

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

We measured the urinary nitrite and nitrate (NO_x^–) excretion, an index of endogenous nitric oxide formation, in term and preterm newborns on the 1st and 4th days of age. In the infants of both groups, the urinary NO_x^– excretion significantly increased from the 1st to the 4th day. The urinary NO_x^– excretion in preterm infants was significantly higher as compared with term babies on both days. Furthermore, the urinary NO_x^– excretion was significantly elevated in preterm infants with respiratory distress syndrome as compared with those without cardiopulmonary complications on the 4th day. These changes of urinary NO_x^–; excretion in newborns strongly suggest the presence of an active physiological role for nitric oxide in the circulatory adaptation to extrauterine life.

Original language	English
Pages (from-to)	322-326
Number of pages	5
Journal	Neonatology
Volume	72
Issue number	5
DOIs	https://doi.org/10.1159/000244499
Publication status	Published - 1997
Externally published	Yes

Keywords

Newborns
Nitric oxide
Respiratory distress syndrome
Urinary nitrate
Urinary nitrite

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Developmental Biology

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abstract = "We measured the urinary nitrite and nitrate (NOx–) excretion, an index of endogenous nitric oxide formation, in term and preterm newborns on the 1st and 4th days of age. In the infants of both groups, the urinary NOx– excretion significantly increased from the 1st to the 4th day. The urinary NOx– excretion in preterm infants was significantly higher as compared with term babies on both days. Furthermore, the urinary NOx– excretion was significantly elevated in preterm infants with respiratory distress syndrome as compared with those without cardiopulmonary complications on the 4th day. These changes of urinary NOx–; excretion in newborns strongly suggest the presence of an active physiological role for nitric oxide in the circulatory adaptation to extrauterine life.",

keywords = "Newborns, Nitric oxide, Respiratory distress syndrome, Urinary nitrate, Urinary nitrite",

author = "Hirokazu Tsukahara and Motohiro Takeuchi and Ikue Hata and Masahiro Hiraoka and Fumikazu Kotsuji and Masakatsu Sudo and Mitsufumi Mayumi",

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T2 - Measurement of Urinary Nitrite and Nitrate Concentrations

AU - Tsukahara, Hirokazu

AU - Takeuchi, Motohiro

AU - Hata, Ikue

AU - Hiraoka, Masahiro

AU - Kotsuji, Fumikazu

AU - Sudo, Masakatsu

AU - Mayumi, Mitsufumi

PY - 1997

Y1 - 1997

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AB - We measured the urinary nitrite and nitrate (NOx–) excretion, an index of endogenous nitric oxide formation, in term and preterm newborns on the 1st and 4th days of age. In the infants of both groups, the urinary NOx– excretion significantly increased from the 1st to the 4th day. The urinary NOx– excretion in preterm infants was significantly higher as compared with term babies on both days. Furthermore, the urinary NOx– excretion was significantly elevated in preterm infants with respiratory distress syndrome as compared with those without cardiopulmonary complications on the 4th day. These changes of urinary NOx–; excretion in newborns strongly suggest the presence of an active physiological role for nitric oxide in the circulatory adaptation to extrauterine life.

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KW - Respiratory distress syndrome

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KW - Urinary nitrite

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Assessment of Endogenous Nitric Oxide Formation in Newborns: Measurement of Urinary Nitrite and Nitrate Concentrations

Abstract

Keywords

ASJC Scopus subject areas

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