Abstract
We measured the urinary nitrite and nitrate (NO(X)-) excretion, an index of endogenous nitric oxide formation, in term and preterm newborns on the 1st and 4th days of age. In the infants of both groups, the urinary NO(X)- excretion significantly increased from the 1st to the 4th day. The urinary NO(X)- excretion in preterm infants was significantly higher as compared with term babies on both days. Furthermore, the urinary NO(X)- excretion was significantly elevated in preterm infants with respiratory distress syndrome as compared with those without cardiopulmonary complications on the 4th day. These changes of urinary NO(X)- excretion in newborns strongly suggest the presence of an active physiological role for nitric oxide in the circulatory adaptation to extrauterine life.
| Original language | English |
|---|---|
| Pages (from-to) | 322-326 |
| Number of pages | 5 |
| Journal | Biology of the Neonate |
| Volume | 72 |
| Issue number | 5 |
| Publication status | Published - Nov 1997 |
| Externally published | Yes |
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Keywords
- Newborns
- Nitric oxide
- Respiratory distress syndrome
- Urinary nitrate
- Urinary nitrite
ASJC Scopus subject areas
- Developmental Biology
- Pediatrics, Perinatology, and Child Health
Cite this
Assessment of endogenous nitric oxide formation in newborns : Measurement of urinary nitrite and nitrate concentrations. / Tsukahara, Hirokazu; Takeuchi, Motohiro; Hata, Ikue; Hiraoka, Masahiro; Kotsuji, Fumikazu; Sudo, Masakatsu; Mayumi, Mitsufumi.
In: Biology of the Neonate, Vol. 72, No. 5, 11.1997, p. 322-326.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Assessment of endogenous nitric oxide formation in newborns
T2 - Measurement of urinary nitrite and nitrate concentrations
AU - Tsukahara, Hirokazu
AU - Takeuchi, Motohiro
AU - Hata, Ikue
AU - Hiraoka, Masahiro
AU - Kotsuji, Fumikazu
AU - Sudo, Masakatsu
AU - Mayumi, Mitsufumi
PY - 1997/11
Y1 - 1997/11
N2 - We measured the urinary nitrite and nitrate (NO(X)-) excretion, an index of endogenous nitric oxide formation, in term and preterm newborns on the 1st and 4th days of age. In the infants of both groups, the urinary NO(X)- excretion significantly increased from the 1st to the 4th day. The urinary NO(X)- excretion in preterm infants was significantly higher as compared with term babies on both days. Furthermore, the urinary NO(X)- excretion was significantly elevated in preterm infants with respiratory distress syndrome as compared with those without cardiopulmonary complications on the 4th day. These changes of urinary NO(X)- excretion in newborns strongly suggest the presence of an active physiological role for nitric oxide in the circulatory adaptation to extrauterine life.
AB - We measured the urinary nitrite and nitrate (NO(X)-) excretion, an index of endogenous nitric oxide formation, in term and preterm newborns on the 1st and 4th days of age. In the infants of both groups, the urinary NO(X)- excretion significantly increased from the 1st to the 4th day. The urinary NO(X)- excretion in preterm infants was significantly higher as compared with term babies on both days. Furthermore, the urinary NO(X)- excretion was significantly elevated in preterm infants with respiratory distress syndrome as compared with those without cardiopulmonary complications on the 4th day. These changes of urinary NO(X)- excretion in newborns strongly suggest the presence of an active physiological role for nitric oxide in the circulatory adaptation to extrauterine life.
KW - Newborns
KW - Nitric oxide
KW - Respiratory distress syndrome
KW - Urinary nitrate
KW - Urinary nitrite
UR - http://www.scopus.com/inward/record.url?scp=0030696130&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030696130&partnerID=8YFLogxK
M3 - Article
VL - 72
SP - 322
EP - 326
JO - Neonatology
JF - Neonatology
SN - 1661-7800
IS - 5
ER -