Assessment of endogenous nitric oxide formation in newborns: Measurement of urinary nitrite and nitrate concentrations

Hirokazu Tsukahara, Motohiro Takeuchi, Ikue Hata, Masahiro Hiraoka, Fumikazu Kotsuji, Masakatsu Sudo, Mitsufumi Mayumi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We measured the urinary nitrite and nitrate (NO(X)-) excretion, an index of endogenous nitric oxide formation, in term and preterm newborns on the 1st and 4th days of age. In the infants of both groups, the urinary NO(X)- excretion significantly increased from the 1st to the 4th day. The urinary NO(X)- excretion in preterm infants was significantly higher as compared with term babies on both days. Furthermore, the urinary NO(X)- excretion was significantly elevated in preterm infants with respiratory distress syndrome as compared with those without cardiopulmonary complications on the 4th day. These changes of urinary NO(X)- excretion in newborns strongly suggest the presence of an active physiological role for nitric oxide in the circulatory adaptation to extrauterine life.

Original languageEnglish
Pages (from-to)322-326
Number of pages5
JournalBiology of the Neonate
Volume72
Issue number5
Publication statusPublished - Nov 1997
Externally publishedYes

Fingerprint

Nitrites
Premature Infants
Nitrates
Nitric Oxide
Newborn Infant
Newborn Respiratory Distress Syndrome

Keywords

  • Newborns
  • Nitric oxide
  • Respiratory distress syndrome
  • Urinary nitrate
  • Urinary nitrite

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Cite this

Tsukahara, H., Takeuchi, M., Hata, I., Hiraoka, M., Kotsuji, F., Sudo, M., & Mayumi, M. (1997). Assessment of endogenous nitric oxide formation in newborns: Measurement of urinary nitrite and nitrate concentrations. Biology of the Neonate, 72(5), 322-326.

Assessment of endogenous nitric oxide formation in newborns : Measurement of urinary nitrite and nitrate concentrations. / Tsukahara, Hirokazu; Takeuchi, Motohiro; Hata, Ikue; Hiraoka, Masahiro; Kotsuji, Fumikazu; Sudo, Masakatsu; Mayumi, Mitsufumi.

In: Biology of the Neonate, Vol. 72, No. 5, 11.1997, p. 322-326.

Research output: Contribution to journalArticle

Tsukahara, H, Takeuchi, M, Hata, I, Hiraoka, M, Kotsuji, F, Sudo, M & Mayumi, M 1997, 'Assessment of endogenous nitric oxide formation in newborns: Measurement of urinary nitrite and nitrate concentrations', Biology of the Neonate, vol. 72, no. 5, pp. 322-326.
Tsukahara, Hirokazu ; Takeuchi, Motohiro ; Hata, Ikue ; Hiraoka, Masahiro ; Kotsuji, Fumikazu ; Sudo, Masakatsu ; Mayumi, Mitsufumi. / Assessment of endogenous nitric oxide formation in newborns : Measurement of urinary nitrite and nitrate concentrations. In: Biology of the Neonate. 1997 ; Vol. 72, No. 5. pp. 322-326.
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