Assessing the progression of chronic periodontitis using subgingival pathogen levels: A 24-month prospective multicenter cohort study

E. Kakuta, Y. Nomura, T. Morozumi, T. Nakagawa, T. Nakamura, K. Noguchi, A. Yoshimura, Y. Hara, O. Fujise, F. Nishimura, T. Kono, M. Umeda, M. Fukuda, T. Noguchi, N. Yoshinari, C. Fukaya, S. Sekino, Y. Numabe, N. Sugano, K. ItoH. Kobayashi, Y. Izumi, H. Takai, Y. Ogata, S. Takano, M. Minabe, A. Makino-Oi, A. Saito, Y. Abe, S. Sato, F. Suzuki, K. Takahashi, T. Sugaya, M. Kawanami, N. Hanada, Shogo Takashiba, H. Yoshie

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: The diagnosis of the progression of periodontitis presently depends on the use of clinical symptoms (such as attachment loss) and radiographic imaging. The aim of the multicenter study described here was to evaluate the diagnostic use of the bacterial content of subgingival plaque recovered from the deepest pockets in assessing disease progression in chronic periodontitis patients. Methods: This study consisted of a 24-month investigation of a total of 163 patients with chronic periodontitis who received trimonthly follow-up care. Subgingival plaque from the deepest pockets was recovered and assessed for bacterial content of Porphyromonas gingivalis, Prevotella intermedia, and Aggregatibacter actinomycetemcomitans using the modified Invader PLUS assay. The corresponding serum IgG titers were measured using ELISA. Changes in clinical parameters were evaluated over the course of 24 months. The sensitivity, specificity, and prediction values were calculated and used to determine cutoff points for prediction of the progression of chronic periodontitis. Results: Of the 124 individuals who completed the 24-month monitoring phase, 62 exhibited progression of periodontitis, whereas 62 demonstrated stable disease. The P. gingivalis counts of subgingival plaque from the deepest pockets was significantly associated with the progression of periodontitis (p < 0.001, positive predictive value = 0.708). Conclusions: The P. gingivalis counts of subgingival plaque from the deepest pockets may be associated with the progression of periodontitis.

Original languageEnglish
Article number46
JournalBMC Oral Health
Volume17
Issue number1
DOIs
Publication statusPublished - Jan 16 2017

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Chronic Periodontitis
Periodontitis
Porphyromonas gingivalis
Multicenter Studies
Cohort Studies
Prevotella intermedia
Aggregatibacter actinomycetemcomitans
Aftercare
Disease Progression
Immunoglobulin G
Enzyme-Linked Immunosorbent Assay
Sensitivity and Specificity
Serum

Keywords

  • Periodontal stability
  • Porphyromonas gingivalis
  • Progression of periodontitis
  • Subgingival plaque

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Assessing the progression of chronic periodontitis using subgingival pathogen levels : A 24-month prospective multicenter cohort study. / Kakuta, E.; Nomura, Y.; Morozumi, T.; Nakagawa, T.; Nakamura, T.; Noguchi, K.; Yoshimura, A.; Hara, Y.; Fujise, O.; Nishimura, F.; Kono, T.; Umeda, M.; Fukuda, M.; Noguchi, T.; Yoshinari, N.; Fukaya, C.; Sekino, S.; Numabe, Y.; Sugano, N.; Ito, K.; Kobayashi, H.; Izumi, Y.; Takai, H.; Ogata, Y.; Takano, S.; Minabe, M.; Makino-Oi, A.; Saito, A.; Abe, Y.; Sato, S.; Suzuki, F.; Takahashi, K.; Sugaya, T.; Kawanami, M.; Hanada, N.; Takashiba, Shogo; Yoshie, H.

In: BMC Oral Health, Vol. 17, No. 1, 46, 16.01.2017.

Research output: Contribution to journalArticle

Kakuta, E, Nomura, Y, Morozumi, T, Nakagawa, T, Nakamura, T, Noguchi, K, Yoshimura, A, Hara, Y, Fujise, O, Nishimura, F, Kono, T, Umeda, M, Fukuda, M, Noguchi, T, Yoshinari, N, Fukaya, C, Sekino, S, Numabe, Y, Sugano, N, Ito, K, Kobayashi, H, Izumi, Y, Takai, H, Ogata, Y, Takano, S, Minabe, M, Makino-Oi, A, Saito, A, Abe, Y, Sato, S, Suzuki, F, Takahashi, K, Sugaya, T, Kawanami, M, Hanada, N, Takashiba, S & Yoshie, H 2017, 'Assessing the progression of chronic periodontitis using subgingival pathogen levels: A 24-month prospective multicenter cohort study', BMC Oral Health, vol. 17, no. 1, 46. https://doi.org/10.1186/s12903-017-0337-x
Kakuta, E. ; Nomura, Y. ; Morozumi, T. ; Nakagawa, T. ; Nakamura, T. ; Noguchi, K. ; Yoshimura, A. ; Hara, Y. ; Fujise, O. ; Nishimura, F. ; Kono, T. ; Umeda, M. ; Fukuda, M. ; Noguchi, T. ; Yoshinari, N. ; Fukaya, C. ; Sekino, S. ; Numabe, Y. ; Sugano, N. ; Ito, K. ; Kobayashi, H. ; Izumi, Y. ; Takai, H. ; Ogata, Y. ; Takano, S. ; Minabe, M. ; Makino-Oi, A. ; Saito, A. ; Abe, Y. ; Sato, S. ; Suzuki, F. ; Takahashi, K. ; Sugaya, T. ; Kawanami, M. ; Hanada, N. ; Takashiba, Shogo ; Yoshie, H. / Assessing the progression of chronic periodontitis using subgingival pathogen levels : A 24-month prospective multicenter cohort study. In: BMC Oral Health. 2017 ; Vol. 17, No. 1.
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T2 - A 24-month prospective multicenter cohort study

AU - Kakuta, E.

AU - Nomura, Y.

AU - Morozumi, T.

AU - Nakagawa, T.

AU - Nakamura, T.

AU - Noguchi, K.

AU - Yoshimura, A.

AU - Hara, Y.

AU - Fujise, O.

AU - Nishimura, F.

AU - Kono, T.

AU - Umeda, M.

AU - Fukuda, M.

AU - Noguchi, T.

AU - Yoshinari, N.

AU - Fukaya, C.

AU - Sekino, S.

AU - Numabe, Y.

AU - Sugano, N.

AU - Ito, K.

AU - Kobayashi, H.

AU - Izumi, Y.

AU - Takai, H.

AU - Ogata, Y.

AU - Takano, S.

AU - Minabe, M.

AU - Makino-Oi, A.

AU - Saito, A.

AU - Abe, Y.

AU - Sato, S.

AU - Suzuki, F.

AU - Takahashi, K.

AU - Sugaya, T.

AU - Kawanami, M.

AU - Hanada, N.

AU - Takashiba, Shogo

AU - Yoshie, H.

PY - 2017/1/16

Y1 - 2017/1/16

N2 - Background: The diagnosis of the progression of periodontitis presently depends on the use of clinical symptoms (such as attachment loss) and radiographic imaging. The aim of the multicenter study described here was to evaluate the diagnostic use of the bacterial content of subgingival plaque recovered from the deepest pockets in assessing disease progression in chronic periodontitis patients. Methods: This study consisted of a 24-month investigation of a total of 163 patients with chronic periodontitis who received trimonthly follow-up care. Subgingival plaque from the deepest pockets was recovered and assessed for bacterial content of Porphyromonas gingivalis, Prevotella intermedia, and Aggregatibacter actinomycetemcomitans using the modified Invader PLUS assay. The corresponding serum IgG titers were measured using ELISA. Changes in clinical parameters were evaluated over the course of 24 months. The sensitivity, specificity, and prediction values were calculated and used to determine cutoff points for prediction of the progression of chronic periodontitis. Results: Of the 124 individuals who completed the 24-month monitoring phase, 62 exhibited progression of periodontitis, whereas 62 demonstrated stable disease. The P. gingivalis counts of subgingival plaque from the deepest pockets was significantly associated with the progression of periodontitis (p < 0.001, positive predictive value = 0.708). Conclusions: The P. gingivalis counts of subgingival plaque from the deepest pockets may be associated with the progression of periodontitis.

AB - Background: The diagnosis of the progression of periodontitis presently depends on the use of clinical symptoms (such as attachment loss) and radiographic imaging. The aim of the multicenter study described here was to evaluate the diagnostic use of the bacterial content of subgingival plaque recovered from the deepest pockets in assessing disease progression in chronic periodontitis patients. Methods: This study consisted of a 24-month investigation of a total of 163 patients with chronic periodontitis who received trimonthly follow-up care. Subgingival plaque from the deepest pockets was recovered and assessed for bacterial content of Porphyromonas gingivalis, Prevotella intermedia, and Aggregatibacter actinomycetemcomitans using the modified Invader PLUS assay. The corresponding serum IgG titers were measured using ELISA. Changes in clinical parameters were evaluated over the course of 24 months. The sensitivity, specificity, and prediction values were calculated and used to determine cutoff points for prediction of the progression of chronic periodontitis. Results: Of the 124 individuals who completed the 24-month monitoring phase, 62 exhibited progression of periodontitis, whereas 62 demonstrated stable disease. The P. gingivalis counts of subgingival plaque from the deepest pockets was significantly associated with the progression of periodontitis (p < 0.001, positive predictive value = 0.708). Conclusions: The P. gingivalis counts of subgingival plaque from the deepest pockets may be associated with the progression of periodontitis.

KW - Periodontal stability

KW - Porphyromonas gingivalis

KW - Progression of periodontitis

KW - Subgingival plaque

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