Abstract
Background: The diagnosis of the progression of periodontitis presently depends on the use of clinical symptoms (such as attachment loss) and radiographic imaging. The aim of the multicenter study described here was to evaluate the diagnostic use of the bacterial content of subgingival plaque recovered from the deepest pockets in assessing disease progression in chronic periodontitis patients. Methods: This study consisted of a 24-month investigation of a total of 163 patients with chronic periodontitis who received trimonthly follow-up care. Subgingival plaque from the deepest pockets was recovered and assessed for bacterial content of Porphyromonas gingivalis, Prevotella intermedia, and Aggregatibacter actinomycetemcomitans using the modified Invader PLUS assay. The corresponding serum IgG titers were measured using ELISA. Changes in clinical parameters were evaluated over the course of 24 months. The sensitivity, specificity, and prediction values were calculated and used to determine cutoff points for prediction of the progression of chronic periodontitis. Results: Of the 124 individuals who completed the 24-month monitoring phase, 62 exhibited progression of periodontitis, whereas 62 demonstrated stable disease. The P. gingivalis counts of subgingival plaque from the deepest pockets was significantly associated with the progression of periodontitis (p < 0.001, positive predictive value = 0.708). Conclusions: The P. gingivalis counts of subgingival plaque from the deepest pockets may be associated with the progression of periodontitis.
| Original language | English |
|---|---|
| Article number | 46 |
| Journal | BMC Oral Health |
| Volume | 17 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 16 2017 |
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Keywords
- Periodontal stability
- Porphyromonas gingivalis
- Progression of periodontitis
- Subgingival plaque
ASJC Scopus subject areas
- Dentistry(all)
Cite this
Assessing the progression of chronic periodontitis using subgingival pathogen levels : A 24-month prospective multicenter cohort study. / Kakuta, E.; Nomura, Y.; Morozumi, T.; Nakagawa, T.; Nakamura, T.; Noguchi, K.; Yoshimura, A.; Hara, Y.; Fujise, O.; Nishimura, F.; Kono, T.; Umeda, M.; Fukuda, M.; Noguchi, T.; Yoshinari, N.; Fukaya, C.; Sekino, S.; Numabe, Y.; Sugano, N.; Ito, K.; Kobayashi, H.; Izumi, Y.; Takai, H.; Ogata, Y.; Takano, S.; Minabe, M.; Makino-Oi, A.; Saito, A.; Abe, Y.; Sato, S.; Suzuki, F.; Takahashi, K.; Sugaya, T.; Kawanami, M.; Hanada, N.; Takashiba, Shogo; Yoshie, H.
In: BMC Oral Health, Vol. 17, No. 1, 46, 16.01.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Assessing the progression of chronic periodontitis using subgingival pathogen levels
T2 - A 24-month prospective multicenter cohort study
AU - Kakuta, E.
AU - Nomura, Y.
AU - Morozumi, T.
AU - Nakagawa, T.
AU - Nakamura, T.
AU - Noguchi, K.
AU - Yoshimura, A.
AU - Hara, Y.
AU - Fujise, O.
AU - Nishimura, F.
AU - Kono, T.
AU - Umeda, M.
AU - Fukuda, M.
AU - Noguchi, T.
AU - Yoshinari, N.
AU - Fukaya, C.
AU - Sekino, S.
AU - Numabe, Y.
AU - Sugano, N.
AU - Ito, K.
AU - Kobayashi, H.
AU - Izumi, Y.
AU - Takai, H.
AU - Ogata, Y.
AU - Takano, S.
AU - Minabe, M.
AU - Makino-Oi, A.
AU - Saito, A.
AU - Abe, Y.
AU - Sato, S.
AU - Suzuki, F.
AU - Takahashi, K.
AU - Sugaya, T.
AU - Kawanami, M.
AU - Hanada, N.
AU - Takashiba, Shogo
AU - Yoshie, H.
PY - 2017/1/16
Y1 - 2017/1/16
N2 - Background: The diagnosis of the progression of periodontitis presently depends on the use of clinical symptoms (such as attachment loss) and radiographic imaging. The aim of the multicenter study described here was to evaluate the diagnostic use of the bacterial content of subgingival plaque recovered from the deepest pockets in assessing disease progression in chronic periodontitis patients. Methods: This study consisted of a 24-month investigation of a total of 163 patients with chronic periodontitis who received trimonthly follow-up care. Subgingival plaque from the deepest pockets was recovered and assessed for bacterial content of Porphyromonas gingivalis, Prevotella intermedia, and Aggregatibacter actinomycetemcomitans using the modified Invader PLUS assay. The corresponding serum IgG titers were measured using ELISA. Changes in clinical parameters were evaluated over the course of 24 months. The sensitivity, specificity, and prediction values were calculated and used to determine cutoff points for prediction of the progression of chronic periodontitis. Results: Of the 124 individuals who completed the 24-month monitoring phase, 62 exhibited progression of periodontitis, whereas 62 demonstrated stable disease. The P. gingivalis counts of subgingival plaque from the deepest pockets was significantly associated with the progression of periodontitis (p < 0.001, positive predictive value = 0.708). Conclusions: The P. gingivalis counts of subgingival plaque from the deepest pockets may be associated with the progression of periodontitis.
AB - Background: The diagnosis of the progression of periodontitis presently depends on the use of clinical symptoms (such as attachment loss) and radiographic imaging. The aim of the multicenter study described here was to evaluate the diagnostic use of the bacterial content of subgingival plaque recovered from the deepest pockets in assessing disease progression in chronic periodontitis patients. Methods: This study consisted of a 24-month investigation of a total of 163 patients with chronic periodontitis who received trimonthly follow-up care. Subgingival plaque from the deepest pockets was recovered and assessed for bacterial content of Porphyromonas gingivalis, Prevotella intermedia, and Aggregatibacter actinomycetemcomitans using the modified Invader PLUS assay. The corresponding serum IgG titers were measured using ELISA. Changes in clinical parameters were evaluated over the course of 24 months. The sensitivity, specificity, and prediction values were calculated and used to determine cutoff points for prediction of the progression of chronic periodontitis. Results: Of the 124 individuals who completed the 24-month monitoring phase, 62 exhibited progression of periodontitis, whereas 62 demonstrated stable disease. The P. gingivalis counts of subgingival plaque from the deepest pockets was significantly associated with the progression of periodontitis (p < 0.001, positive predictive value = 0.708). Conclusions: The P. gingivalis counts of subgingival plaque from the deepest pockets may be associated with the progression of periodontitis.
KW - Periodontal stability
KW - Porphyromonas gingivalis
KW - Progression of periodontitis
KW - Subgingival plaque
UR - http://www.scopus.com/inward/record.url?scp=85009962387&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85009962387&partnerID=8YFLogxK
U2 - 10.1186/s12903-017-0337-x
DO - 10.1186/s12903-017-0337-x
M3 - Article
C2 - 28093069
AN - SCOPUS:85009962387
VL - 17
JO - BMC Oral Health
JF - BMC Oral Health
SN - 1472-6831
IS - 1
M1 - 46
ER -