Aspartate-immunoreactive primary sensory neurons in the mouse trigeminal ganglion

H. Ichikawa, S. Matsuo, R. Terayama, T. Yamaai, T. Sugimoto

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Aspartate-immunoreactivity (ir) was examined in the mouse trigeminal ganglion (TG). The ir was detected in 34% of TG neurons and their cell bodies were of various sizes (mean ± S.D. = 1234 ± 543 μm2). A triple immunofluorescence method revealed the co-expression of aspartate with calcitonin gene-related peptide (CGRP) and parvalbumin; 22% and 14% of aspartate-immunoreactive (ir) neurons were also immunoreactive for CGRP and parvalbumin, respectively. The co-expression of aspartate with both CGRP and parvalbumin was very rare in the TG. By retrograde tracing method, half and 66% of TG neurons which innervate the vibrissa and palate, respectively, contained aspartate-ir. The co-expression of aspartate with CGRP was more common among palatal neurons (36%) compared to vibrissal neurons (22%). Aspartate-ir neurons which co-expressed parvalbumin-ir were numerous in the vibrissa (17%) but not in the palate (4%). These findings may suggest that the function of aspartate-containing TG neurons is correlated with their peripheral receptive fields.

Original languageEnglish
Pages (from-to)67-72
Number of pages6
JournalBrain Research
Volume1082
Issue number1
DOIs
Publication statusPublished - Apr 12 2006

Keywords

  • Aspartate
  • Calcitonin gene-related peptide
  • Immunohistochemistry
  • Palate
  • Parvalbumin
  • Trigeminal ganglion
  • Vibrissa

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Aspartate-immunoreactive primary sensory neurons in the mouse trigeminal ganglion'. Together they form a unique fingerprint.

Cite this