Aspartate-immunoreactive primary sensory neurons in the mouse trigeminal ganglion

H. Ichikawa, S. Matsuo, R. Terayama, T. Yamaai, T. Sugimoto

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Aspartate-immunoreactivity (ir) was examined in the mouse trigeminal ganglion (TG). The ir was detected in 34% of TG neurons and their cell bodies were of various sizes (mean ± S.D. = 1234 ± 543 μm2). A triple immunofluorescence method revealed the co-expression of aspartate with calcitonin gene-related peptide (CGRP) and parvalbumin; 22% and 14% of aspartate-immunoreactive (ir) neurons were also immunoreactive for CGRP and parvalbumin, respectively. The co-expression of aspartate with both CGRP and parvalbumin was very rare in the TG. By retrograde tracing method, half and 66% of TG neurons which innervate the vibrissa and palate, respectively, contained aspartate-ir. The co-expression of aspartate with CGRP was more common among palatal neurons (36%) compared to vibrissal neurons (22%). Aspartate-ir neurons which co-expressed parvalbumin-ir were numerous in the vibrissa (17%) but not in the palate (4%). These findings may suggest that the function of aspartate-containing TG neurons is correlated with their peripheral receptive fields.

Original languageEnglish
Pages (from-to)67-72
Number of pages6
JournalBrain Research
Volume1082
Issue number1
DOIs
Publication statusPublished - Apr 12 2006

Fingerprint

Trigeminal Ganglion
Sensory Receptor Cells
Aspartic Acid
Parvalbumins
Calcitonin Gene-Related Peptide
Neurons
Vibrissae
Palate
Fluorescent Antibody Technique

Keywords

  • Aspartate
  • Calcitonin gene-related peptide
  • Immunohistochemistry
  • Palate
  • Parvalbumin
  • Trigeminal ganglion
  • Vibrissa

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

Ichikawa, H., Matsuo, S., Terayama, R., Yamaai, T., & Sugimoto, T. (2006). Aspartate-immunoreactive primary sensory neurons in the mouse trigeminal ganglion. Brain Research, 1082(1), 67-72. https://doi.org/10.1016/j.brainres.2006.01.092

Aspartate-immunoreactive primary sensory neurons in the mouse trigeminal ganglion. / Ichikawa, H.; Matsuo, S.; Terayama, R.; Yamaai, T.; Sugimoto, T.

In: Brain Research, Vol. 1082, No. 1, 12.04.2006, p. 67-72.

Research output: Contribution to journalArticle

Ichikawa, H, Matsuo, S, Terayama, R, Yamaai, T & Sugimoto, T 2006, 'Aspartate-immunoreactive primary sensory neurons in the mouse trigeminal ganglion', Brain Research, vol. 1082, no. 1, pp. 67-72. https://doi.org/10.1016/j.brainres.2006.01.092
Ichikawa, H. ; Matsuo, S. ; Terayama, R. ; Yamaai, T. ; Sugimoto, T. / Aspartate-immunoreactive primary sensory neurons in the mouse trigeminal ganglion. In: Brain Research. 2006 ; Vol. 1082, No. 1. pp. 67-72.
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