ASIC3-immunoreactive neurons in the rat vagal and glossopharyngeal sensory ganglia

T. Fukuda, H. Ichikawa, R. Terayama, T. Yamaai, T. Kuboki, T. Sugimoto

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

ASIC3-immunoreactivity (ir) was examined in the rat vagal and glossopharyngeal sensory ganglia. In the jugular, petrosal and nodose ganglia, 24.8%, 30.8% and 20.6% of sensory neurons, respectively, were immunoreactive for ASIC3. These neurons were observed throughout the ganglia. A double immunofluorescence method demonstrated that many ASIC3-immunoreactive (ir) neurons co-expressed calcitonin gene-related peptide (CGRP)- or vanilloid receptor subtype 1 (VRL-1)-ir in the jugular (CGRP, 77.8%; VRL-1, 28.0%) and petrosal ganglia (CGRP, 61.7%; VRL-1, 21.5%). In the nodose ganglion, however, such neurons were relatively rare (CGRP, 6.3%; VRL-1, 0.4%). ASIC3-ir neurons were mostly devoid of tyrosine hydroxylase in these ganglia. However, some ASIC3-ir neurons co-expressed calbindin D-28k in the petrosal (5.5%) and nodose ganglia (3.8%). These findings may suggest that ASIC3-containing neurons have a wide variety of sensory modalities in the vagal and glossopharyngeal sensory ganglia.

Original languageEnglish
Pages (from-to)150-155
Number of pages6
JournalBrain Research
Volume1081
Issue number1
DOIs
Publication statusPublished - Apr 7 2006

Keywords

  • ASIC3
  • CGRP
  • Jugular ganglion
  • Nodose ganglion
  • Petrosal ganglion
  • VRL-1

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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