Asialoglycoprotein receptor concentration in tumor-bearing livers and its fate early after their sectorial resection

Xiao Feng Li, Junichi Taki, Seigo Kinuya, Takahiro Higuchi, Shota Konishi, Eui Hyo Hwang, Noriyuki Shuke, Kenichi Nakajima, Norihisa Tonami

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The aim of the present study was to investigate asialoglycoprotein receptor (ASGP-R) status in tumor-bearing livers and early after their sectorial resection employing 99mTc-DTPA-galactosyl human serum albumin (99mTc-GSA) dynamic SPECT. Methods: Ten normal liver controls and 44 liver tumor patients who underwent sectorial hepatectomy were included in the study. 99mTc-GSA dynamic SPECT study was performed 7 ± 3 d before (pre-operative) and 34 ± 13 d after surgery (post-operative) in liver tumour patients. Pre- and post-operative parameters including hepatic functional volume and 99mTc-GSA clearance of unit hepatic functional volume, representing ASGP-R concentration, were measured. The sum of functional volume of the sectors uninvolved in hepatectomy was defined as residual functional volume. Subsequently, post-operative change in functional volume (the ratio of post-operative to residual functional volume), post-operative change in 99mTc-GSA clearance of unit hepatic functional volume (the ratio of post- to pre-operative 99mTc-GSA clearance of unit hepatic functional volume) and percent resection of functional volume were calculated. Results: Pre-operative 99mTc-GSA clearance of unit hepatic functional volume in tumor-bearing livers was significantly lower than that in non-tumor bearing control liver. The ratio of post- to pre-operative 99mTc-GSA clearance of unit hepatic functional volume showed marked variation from 0.57 to 2.14, which negatively correlated with the percent resection of functional volume (r = -0.58, p < 0.0001). The ratio of post- to pre-operative 99mTc-GSA clearance of unit hepatic functional volume exhibited a negative correlation with the ratio of post-operative to estimated residual functional volume (r = -0.67, p < 0.0001). Conclusion: ASGP-R concentration is reduced in the presence of liver tumor. ASGP-R concentration reveals variable changes early after sectorial resection; the change negatively correlates with percent resection of hepatic functional volume. Post-operative change in ASGP-R concentration negatively correlates with change in functional volume.

Original languageEnglish
Pages (from-to)489-493
Number of pages5
JournalAnnals of nuclear medicine
Volume17
Issue number6
DOIs
Publication statusPublished - Sep 2003
Externally publishedYes

Keywords

  • Asialoglycoprotein receptor
  • Dynamic SPECT
  • Liver neoplasm
  • Liver resection
  • Tc-DTPA-galactosyl human serum albumin

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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