Asialoglycoprotein receptor concentration in tumor-bearing livers and its fate early after their sectorial resection

Xiao Feng Li, Junichi Taki, Seigo Kinuya, Takahiro Higuchi, Shota Konishi, Eui Hyo Hwang, Noriyuki Shuke, Kenichi Nakajima, Norihisa Tonami

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Abstract

The aim of the present study was to investigate asialoglycoprotein receptor (ASGP-R) status in tumor-bearing livers and early after their sectorial resection employing 99mTc-DTPA-galactosyl human serum albumin (99mTc-GSA) dynamic SPECT. Methods: Ten normal liver controls and 44 liver tumor patients who underwent sectorial hepatectomy were included in the study. 99mTc-GSA dynamic SPECT study was performed 7 ± 3 d before (pre-operative) and 34 ± 13 d after surgery (post-operative) in liver tumour patients. Pre- and post-operative parameters including hepatic functional volume and 99mTc-GSA clearance of unit hepatic functional volume, representing ASGP-R concentration, were measured. The sum of functional volume of the sectors uninvolved in hepatectomy was defined as residual functional volume. Subsequently, post-operative change in functional volume (the ratio of post-operative to residual functional volume), post-operative change in 99mTc-GSA clearance of unit hepatic functional volume (the ratio of post- to pre-operative 99mTc-GSA clearance of unit hepatic functional volume) and percent resection of functional volume were calculated. Results: Pre-operative 99mTc-GSA clearance of unit hepatic functional volume in tumor-bearing livers was significantly lower than that in non-tumor bearing control liver. The ratio of post- to pre-operative 99mTc-GSA clearance of unit hepatic functional volume showed marked variation from 0.57 to 2.14, which negatively correlated with the percent resection of functional volume (r = -0.58, p < 0.0001). The ratio of post- to pre-operative 99mTc-GSA clearance of unit hepatic functional volume exhibited a negative correlation with the ratio of post-operative to estimated residual functional volume (r = -0.67, p < 0.0001). Conclusion: ASGP-R concentration is reduced in the presence of liver tumor. ASGP-R concentration reveals variable changes early after sectorial resection; the change negatively correlates with percent resection of hepatic functional volume. Post-operative change in ASGP-R concentration negatively correlates with change in functional volume.

Original languageEnglish
Pages (from-to)489-493
Number of pages5
JournalAnnals of nuclear medicine
Volume17
Issue number6
DOIs
Publication statusPublished - Sep 2003
Externally publishedYes

Fingerprint

Asialoglycoprotein Receptor
Pentetic Acid
Liver
Serum Albumin
Neoplasms
Residual Volume
Hepatectomy
Single-Photon Emission-Computed Tomography

Keywords

  • Tc-DTPA-galactosyl human serum albumin
  • Asialoglycoprotein receptor
  • Dynamic SPECT
  • Liver neoplasm
  • Liver resection

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Asialoglycoprotein receptor concentration in tumor-bearing livers and its fate early after their sectorial resection. / Li, Xiao Feng; Taki, Junichi; Kinuya, Seigo; Higuchi, Takahiro; Konishi, Shota; Hwang, Eui Hyo; Shuke, Noriyuki; Nakajima, Kenichi; Tonami, Norihisa.

In: Annals of nuclear medicine, Vol. 17, No. 6, 09.2003, p. 489-493.

Research output: Contribution to journalArticle

Li, XF, Taki, J, Kinuya, S, Higuchi, T, Konishi, S, Hwang, EH, Shuke, N, Nakajima, K & Tonami, N 2003, 'Asialoglycoprotein receptor concentration in tumor-bearing livers and its fate early after their sectorial resection', Annals of nuclear medicine, vol. 17, no. 6, pp. 489-493. https://doi.org/10.1007/BF03006440
Li, Xiao Feng ; Taki, Junichi ; Kinuya, Seigo ; Higuchi, Takahiro ; Konishi, Shota ; Hwang, Eui Hyo ; Shuke, Noriyuki ; Nakajima, Kenichi ; Tonami, Norihisa. / Asialoglycoprotein receptor concentration in tumor-bearing livers and its fate early after their sectorial resection. In: Annals of nuclear medicine. 2003 ; Vol. 17, No. 6. pp. 489-493.
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abstract = "The aim of the present study was to investigate asialoglycoprotein receptor (ASGP-R) status in tumor-bearing livers and early after their sectorial resection employing 99mTc-DTPA-galactosyl human serum albumin (99mTc-GSA) dynamic SPECT. Methods: Ten normal liver controls and 44 liver tumor patients who underwent sectorial hepatectomy were included in the study. 99mTc-GSA dynamic SPECT study was performed 7 ± 3 d before (pre-operative) and 34 ± 13 d after surgery (post-operative) in liver tumour patients. Pre- and post-operative parameters including hepatic functional volume and 99mTc-GSA clearance of unit hepatic functional volume, representing ASGP-R concentration, were measured. The sum of functional volume of the sectors uninvolved in hepatectomy was defined as residual functional volume. Subsequently, post-operative change in functional volume (the ratio of post-operative to residual functional volume), post-operative change in 99mTc-GSA clearance of unit hepatic functional volume (the ratio of post- to pre-operative 99mTc-GSA clearance of unit hepatic functional volume) and percent resection of functional volume were calculated. Results: Pre-operative 99mTc-GSA clearance of unit hepatic functional volume in tumor-bearing livers was significantly lower than that in non-tumor bearing control liver. The ratio of post- to pre-operative 99mTc-GSA clearance of unit hepatic functional volume showed marked variation from 0.57 to 2.14, which negatively correlated with the percent resection of functional volume (r = -0.58, p < 0.0001). The ratio of post- to pre-operative 99mTc-GSA clearance of unit hepatic functional volume exhibited a negative correlation with the ratio of post-operative to estimated residual functional volume (r = -0.67, p < 0.0001). Conclusion: ASGP-R concentration is reduced in the presence of liver tumor. ASGP-R concentration reveals variable changes early after sectorial resection; the change negatively correlates with percent resection of hepatic functional volume. Post-operative change in ASGP-R concentration negatively correlates with change in functional volume.",
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AU - Taki, Junichi

AU - Kinuya, Seigo

AU - Higuchi, Takahiro

AU - Konishi, Shota

AU - Hwang, Eui Hyo

AU - Shuke, Noriyuki

AU - Nakajima, Kenichi

AU - Tonami, Norihisa

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N2 - The aim of the present study was to investigate asialoglycoprotein receptor (ASGP-R) status in tumor-bearing livers and early after their sectorial resection employing 99mTc-DTPA-galactosyl human serum albumin (99mTc-GSA) dynamic SPECT. Methods: Ten normal liver controls and 44 liver tumor patients who underwent sectorial hepatectomy were included in the study. 99mTc-GSA dynamic SPECT study was performed 7 ± 3 d before (pre-operative) and 34 ± 13 d after surgery (post-operative) in liver tumour patients. Pre- and post-operative parameters including hepatic functional volume and 99mTc-GSA clearance of unit hepatic functional volume, representing ASGP-R concentration, were measured. The sum of functional volume of the sectors uninvolved in hepatectomy was defined as residual functional volume. Subsequently, post-operative change in functional volume (the ratio of post-operative to residual functional volume), post-operative change in 99mTc-GSA clearance of unit hepatic functional volume (the ratio of post- to pre-operative 99mTc-GSA clearance of unit hepatic functional volume) and percent resection of functional volume were calculated. Results: Pre-operative 99mTc-GSA clearance of unit hepatic functional volume in tumor-bearing livers was significantly lower than that in non-tumor bearing control liver. The ratio of post- to pre-operative 99mTc-GSA clearance of unit hepatic functional volume showed marked variation from 0.57 to 2.14, which negatively correlated with the percent resection of functional volume (r = -0.58, p < 0.0001). The ratio of post- to pre-operative 99mTc-GSA clearance of unit hepatic functional volume exhibited a negative correlation with the ratio of post-operative to estimated residual functional volume (r = -0.67, p < 0.0001). Conclusion: ASGP-R concentration is reduced in the presence of liver tumor. ASGP-R concentration reveals variable changes early after sectorial resection; the change negatively correlates with percent resection of hepatic functional volume. Post-operative change in ASGP-R concentration negatively correlates with change in functional volume.

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KW - Tc-DTPA-galactosyl human serum albumin

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KW - Dynamic SPECT

KW - Liver neoplasm

KW - Liver resection

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