Asbestos induces reduction of tumor immunity

Naoko Kumagai-Takei, Megumi Maeda, Ying Chen, Hidenori Matsuzaki, Suni Lee, Yasumitsu Nishimura, Junichi Hiratsuka, Takemi Otsuki

Research output: Contribution to journalArticle

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Abstract

Asbestos-related cancers such as malignant mesothelioma and lung cancer are an important issue in the world. There are many conflicts concerning economical considerations and medical evidence for these cancers and much confusion regarding details of the pathological mechanisms of asbestos-induced cancers. For example, there is uncertainty concerning the degree of danger of the iron-absent chrysotile compared with iron-containing crocidolite and amosite. However, regarding bad prognosis of mesothelioma, medical approaches to ensure the recognition of the biological effects of asbestos and the pathological mechanisms of asbestos-induced carcinogenesis, as well as clinical trials to detect the early stage of mesothelioma, should result in better preventions and the cure of these malignancies. We have been investigating the immunological effects of asbestos in relation to the reduction of tumor immunity. In this paper, cellular and molecular approaches to clarify the immunological effects of asbestos are described, and all the findings indicate that the reduction of tumor immunity is caused by asbestos exposure and involvement in asbestos-induced cancers. These investigations may not only allow the clear recognition of the biological effects of asbestos, but also present a novel procedure for early detection of previous asbestos exposure and the presence of mesothelioma as well as the chemoprevention of asbestos-related cancers.

Original languageEnglish
Article number481439
JournalClinical and Developmental Immunology
Volume2011
DOIs
Publication statusPublished - 2011

Fingerprint

Asbestos
Immunity
Neoplasms
Mesothelioma
Iron
Amosite Asbestos
Crocidolite Asbestos
Serpentine Asbestos
Chemoprevention
Uncertainty
Lung Neoplasms
Carcinogenesis
Clinical Trials

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

Cite this

Kumagai-Takei, N., Maeda, M., Chen, Y., Matsuzaki, H., Lee, S., Nishimura, Y., ... Otsuki, T. (2011). Asbestos induces reduction of tumor immunity. Clinical and Developmental Immunology, 2011, [481439]. https://doi.org/10.1155/2011/481439

Asbestos induces reduction of tumor immunity. / Kumagai-Takei, Naoko; Maeda, Megumi; Chen, Ying; Matsuzaki, Hidenori; Lee, Suni; Nishimura, Yasumitsu; Hiratsuka, Junichi; Otsuki, Takemi.

In: Clinical and Developmental Immunology, Vol. 2011, 481439, 2011.

Research output: Contribution to journalArticle

Kumagai-Takei, N, Maeda, M, Chen, Y, Matsuzaki, H, Lee, S, Nishimura, Y, Hiratsuka, J & Otsuki, T 2011, 'Asbestos induces reduction of tumor immunity', Clinical and Developmental Immunology, vol. 2011, 481439. https://doi.org/10.1155/2011/481439
Kumagai-Takei N, Maeda M, Chen Y, Matsuzaki H, Lee S, Nishimura Y et al. Asbestos induces reduction of tumor immunity. Clinical and Developmental Immunology. 2011;2011. 481439. https://doi.org/10.1155/2011/481439
Kumagai-Takei, Naoko ; Maeda, Megumi ; Chen, Ying ; Matsuzaki, Hidenori ; Lee, Suni ; Nishimura, Yasumitsu ; Hiratsuka, Junichi ; Otsuki, Takemi. / Asbestos induces reduction of tumor immunity. In: Clinical and Developmental Immunology. 2011 ; Vol. 2011.
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