Asbestos-induced cellular and molecular alteration of immunocompetent cells and their relationship with chronic inflammation and carcinogenesis

Hidenori Matsuzaki, Megumi Maeda, Suni Lee, Yasumitsu Nishimura, Naoko Kumagai-Takei, Hiroaki Hayashi, Shoko Yamamoto, Tamayo Hatayama, Yoko Kojima, Rika Tabata, Takumi Kishimoto, Junichi Hiratsuka, Takemi Otsuki

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Asbestos causes lung fibrosis known as asbestosis as well as cancers such as malignant mesothelioma and lung cancer. Asbestos is a mineral silicate containing iron, magnesium, and calcium with a core of SiO2. The immunological effect of silica, SiO2, involves the dysregulation of autoimmunity because of the complications of autoimmune diseases found in silicosis. Asbestos can therefore cause alteration of immunocompetent cells to result in a decline of tumor immunity. Additionally, due to its physical characteristics, asbestos fibers remain in the lung, regional lymph nodes, and the pleural cavity, particularly at the opening sites of lymphatic vessels. Asbestos can induce chronic inflammation in these areas due to the production of reactive oxygen/nitrogen species. As a consequence, immunocompetent cells can have their cellular and molecular features altered by chronic and recurrent encounters with asbestos fibers, and there may be modification by the surrounding inflammation, all of which eventually lead to decreased tumor immunity. In this paper, the brief results of our investigation regarding reduction of tumor immunity of immunocompetent cells exposed to asbestos in vitro are discussed, as are our findings concerned with an investigation of chronic inflammation and analyses of peripheral blood samples derived from patients with pleural plaque and mesothelioma that have been exposed to asbestos.

Original languageEnglish
Article number492608
JournalJournal of Biomedicine and Biotechnology
Volume2012
DOIs
Publication statusPublished - 2012

Fingerprint

Asbestos
Carcinogenesis
Inflammation
Tumors
Immunity
Neoplasms
Silicate minerals
Asbestosis
Reactive Nitrogen Species
Pleural Cavity
Silicosis
Lung
Lymphatic Vessels
Fibers
Mesothelioma
Autoimmunity
Silicon Dioxide
Magnesium
Autoimmune Diseases
Minerals

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Genetics
  • Molecular Biology
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

Cite this

Asbestos-induced cellular and molecular alteration of immunocompetent cells and their relationship with chronic inflammation and carcinogenesis. / Matsuzaki, Hidenori; Maeda, Megumi; Lee, Suni; Nishimura, Yasumitsu; Kumagai-Takei, Naoko; Hayashi, Hiroaki; Yamamoto, Shoko; Hatayama, Tamayo; Kojima, Yoko; Tabata, Rika; Kishimoto, Takumi; Hiratsuka, Junichi; Otsuki, Takemi.

In: Journal of Biomedicine and Biotechnology, Vol. 2012, 492608, 2012.

Research output: Contribution to journalArticle

Matsuzaki, H, Maeda, M, Lee, S, Nishimura, Y, Kumagai-Takei, N, Hayashi, H, Yamamoto, S, Hatayama, T, Kojima, Y, Tabata, R, Kishimoto, T, Hiratsuka, J & Otsuki, T 2012, 'Asbestos-induced cellular and molecular alteration of immunocompetent cells and their relationship with chronic inflammation and carcinogenesis', Journal of Biomedicine and Biotechnology, vol. 2012, 492608. https://doi.org/10.1155/2012/492608
Matsuzaki, Hidenori ; Maeda, Megumi ; Lee, Suni ; Nishimura, Yasumitsu ; Kumagai-Takei, Naoko ; Hayashi, Hiroaki ; Yamamoto, Shoko ; Hatayama, Tamayo ; Kojima, Yoko ; Tabata, Rika ; Kishimoto, Takumi ; Hiratsuka, Junichi ; Otsuki, Takemi. / Asbestos-induced cellular and molecular alteration of immunocompetent cells and their relationship with chronic inflammation and carcinogenesis. In: Journal of Biomedicine and Biotechnology. 2012 ; Vol. 2012.
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