Aryl-aryl coupling reaction using a novel and highly active palladium reagent prepared from Pd(OAc)2, 1,3-Bis[diphenylphosphino]propane (DPPP), and Bu3P

Takashi Harayama, Toshihiko Akiyama, Yuichiro Nakano, Hiromi Nishioka, Hitoshi Abe, Yasuo Takeuchi

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

A palladium-assisted coupling reaction of aryl triflate with arene was investigated, and a novel Pd reagent prepared from equimolar Pd(OAc) 2, 1,3-Bis[diphenylphosphino]propane (DPPP), and Bu3P was developed. This method is useful for intramolecular biaryl coupling reactions, not only between aryl triflate and arene (triflate-amide), but also between aryl halide and arene (halo-amide).

Original languageEnglish
Pages (from-to)519-522
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume50
Issue number4
DOIs
Publication statusPublished - Apr 1 2002

Keywords

  • Aryl halide-arene coupling
  • Aryl triflate-arene coupling
  • Biaryl coupling
  • Bidentate ligand
  • Palladium

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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