Artificial baroreflex clinical application of a bionic baroreflex system

Fumiyasu Yamasaki, Takahiro Ushida, Takeshi Yokoyama, Motonori Ando, Koichi Yamashita, Takayuki Sato

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background - We proposed a novel therapeutic strategy against central baroreflex failure: implementation of an artificial baroreflex system to automatically regulate sympathetic vasomotor tone, ie, a bionic baroreflex system (BBS), and we tested its efficacy in a model of sudden hypotension during surgery. Methods and Results - The BBS consisted of a computer-controlled negative-feedback circuit that sensed arterial pressure (AP) and automatically computed the frequency (STM) of a pulse train required to stimulate sympathetic nerves via an epidural catheter placed at the level of the lower thoracic spinal cord. An operation rule was subsequently designed for the BBS using a feedback correction with proportional and integral gain factors. The transfer function from STM to AP was identified by a white noise system identification method in 12 sevoflurane-anesthetized patients undergoing orthopedic surgery involving the cervical vertebrae, and the feedback correction factors were determined with a numerical simulation to enable the BBS to quickly and stably attenuate an external disturbance on AP. The performance of the designed BBS was then examined in a model of orthostatic hypotension during knee joint surgery (n=21). Without the implementation of the BBS, a sudden deflation of a thigh tourniquet resulted in a 17±3 mm Hg decrease in AP within 10 seconds and a 25±2 mm Hg decrease in AP within 50 seconds. By contrast, during real-time execution of the BBS, the decrease in AP was 9±2 mm Hg at 10 seconds and 1±2 mm Hg at 50 seconds after the deflation. Conclusions - These results suggest the feasibility of a BBS approach for central baroreflex failure.

Original languageEnglish
Pages (from-to)634-639
Number of pages6
JournalCirculation
Volume113
Issue number5
DOIs
Publication statusPublished - Feb 2006
Externally publishedYes

Fingerprint

Bionics
Baroreflex
Arterial Pressure
Cervical Vertebrae
Tourniquets
Orthostatic Hypotension
Knee Joint
Thigh
Hypotension
Orthopedics
Spinal Cord

Keywords

  • Baroreceptors
  • Blood pressure
  • Computers
  • Electrical stimulation
  • Nervous system, sympathetic

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Yamasaki, F., Ushida, T., Yokoyama, T., Ando, M., Yamashita, K., & Sato, T. (2006). Artificial baroreflex clinical application of a bionic baroreflex system. Circulation, 113(5), 634-639. https://doi.org/10.1161/CIRCULATIONAHA.105.587915

Artificial baroreflex clinical application of a bionic baroreflex system. / Yamasaki, Fumiyasu; Ushida, Takahiro; Yokoyama, Takeshi; Ando, Motonori; Yamashita, Koichi; Sato, Takayuki.

In: Circulation, Vol. 113, No. 5, 02.2006, p. 634-639.

Research output: Contribution to journalArticle

Yamasaki, F, Ushida, T, Yokoyama, T, Ando, M, Yamashita, K & Sato, T 2006, 'Artificial baroreflex clinical application of a bionic baroreflex system', Circulation, vol. 113, no. 5, pp. 634-639. https://doi.org/10.1161/CIRCULATIONAHA.105.587915
Yamasaki, Fumiyasu ; Ushida, Takahiro ; Yokoyama, Takeshi ; Ando, Motonori ; Yamashita, Koichi ; Sato, Takayuki. / Artificial baroreflex clinical application of a bionic baroreflex system. In: Circulation. 2006 ; Vol. 113, No. 5. pp. 634-639.
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