Arterial Stiffness is an Independent Risk Factor for Anemia after Percutaneous Native Kidney Biopsy

Keiko Tanaka, Masashi Kitagawa, Akifumi Onishi, Toshio Yamanari, Ayu Ogawa-Akiyama, Koki Mise, Tatsuyuki Inoue, Hiroshi Morinaga, Haruhito Adam Uchida, Hitoshi Sugiyama, Jun Wada

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background/Aims: Bleeding is the most common complication after renal biopsy. Although numerous predictors of bleeding have been reported, it remains unclear whether arterial stiffness affects bleeding complications. Method: We performed an observational study of the renal biopsies performed in our division over an approximately 6-year period (May 2010 to May 2016). The clinical and laboratory factors were analyzed to reveal the risk factors associated with bleeding, with a focus on anemia (defined as a ≥10% decrease in hemoglobin [Hb] after biopsy). The brachial-ankle pulse wave velocity (baPWV) was measured to evaluate arterial stiffness. Results: This study included 462 patients (male, n=244; female, n=218). Anemia (defined above) was observed in 54 patients (11.7%). The risk of anemia was higher in women, older patients, and patients with lower serum albumin, lower eGFR and lower diastolic blood pressure after biopsy. We then performed a further analysis of 187 patients whose baPWV data were available. Multivariate analysis revealed that a higher baPWV was an independent risk factor for anemia. ROC analysis for predicting anemia found that a baPWV value of 1839 cm/s had the best performance (AUC 0.689). Conclusion: An increased baPWV may be a more valuable predictor of bleeding than any of the other reported risk factors.

Original languageEnglish
Pages (from-to)284-293
Number of pages10
JournalKidney and Blood Pressure Research
Volume42
Issue number2
DOIs
Publication statusPublished - Jun 1 2017

Fingerprint

Pulse Wave Analysis
Vascular Stiffness
Ankle
Anemia
Arm
Hemorrhage
Kidney
Biopsy
Blood Pressure
Serum Albumin
ROC Curve
Area Under Curve
Observational Studies
Hemoglobins
Multivariate Analysis

Keywords

  • Bleeding
  • Brachial-ankle pulse wave velocity
  • Hemoglobin
  • Renal biopsy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Nephrology

Cite this

Arterial Stiffness is an Independent Risk Factor for Anemia after Percutaneous Native Kidney Biopsy. / Tanaka, Keiko; Kitagawa, Masashi; Onishi, Akifumi; Yamanari, Toshio; Ogawa-Akiyama, Ayu; Mise, Koki; Inoue, Tatsuyuki; Morinaga, Hiroshi; Uchida, Haruhito Adam; Sugiyama, Hitoshi; Wada, Jun.

In: Kidney and Blood Pressure Research, Vol. 42, No. 2, 01.06.2017, p. 284-293.

Research output: Contribution to journalArticle

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