Arterial carbon dioxide tension and outcome in patients admitted to the intensive care unit after cardiac arrest

Antoine G. Schneider, Glenn M. Eastwood, Rinaldo Bellomo, Michael Bailey, Miklos Lipcsey, David Pilcher, Paul Young, Peter Stow, John Santamaria, Edward Stachowski, Satoshi Suzuki, Nicholas C. Woinarski, Janine Pilcher

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Background: Arterial carbon dioxide tension (PaCO2) affects neuronal function and cerebral blood flow. However, its association with outcome in patients admitted to intensive care unit (ICU) after cardiac arrest (CA) has not been evaluated. Methods and results: Observational cohort study using data from the Australian New Zealand (ANZ) Intensive Care Society Adult-Patient-Database (ANZICS-APD). Outcomes analyses were adjusted for illness severity, co-morbidities, hypothermia, treatment limitations, age, year of admission, glucose, source of admission, PaO2 and propensity score.We studied 16,542 consecutive patients admitted to 125 ANZ ICUs after CA between 2000 and 2011. Using the APD-PaCO2 (obtained within 24h of ICU admission), 3010 (18.2%) were classified into the hypo- (PaCO245mmHg) group. The hypocapnia group, compared with the normocapnia group, had a trend toward higher in-hospital mortality (OR 1.12 [95% CI 1.00-1.24, p=0.04]), lower rate of discharge home (OR 0.81 [0.70-0.94, p

Original languageEnglish
Pages (from-to)927-934
Number of pages8
JournalResuscitation
Volume84
Issue number7
DOIs
Publication statusPublished - Jul 2013
Externally publishedYes

Fingerprint

Heart Arrest
Carbon Dioxide
Intensive Care Units
pamidronate
New Zealand
Cerebrovascular Circulation
Hypocapnia
Propensity Score
Hospital Mortality
Hypothermia
Observational Studies
Cohort Studies
Databases
Morbidity
Glucose
Therapeutics

Keywords

  • Carbon dioxide
  • Cardiac arrest
  • Hypercapnia
  • Hypocapnia
  • Intensive care
  • Mortality
  • Outcome
  • Resuscitation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Emergency
  • Emergency Medicine

Cite this

Schneider, A. G., Eastwood, G. M., Bellomo, R., Bailey, M., Lipcsey, M., Pilcher, D., ... Pilcher, J. (2013). Arterial carbon dioxide tension and outcome in patients admitted to the intensive care unit after cardiac arrest. Resuscitation, 84(7), 927-934. https://doi.org/10.1016/j.resuscitation.2013.02.014

Arterial carbon dioxide tension and outcome in patients admitted to the intensive care unit after cardiac arrest. / Schneider, Antoine G.; Eastwood, Glenn M.; Bellomo, Rinaldo; Bailey, Michael; Lipcsey, Miklos; Pilcher, David; Young, Paul; Stow, Peter; Santamaria, John; Stachowski, Edward; Suzuki, Satoshi; Woinarski, Nicholas C.; Pilcher, Janine.

In: Resuscitation, Vol. 84, No. 7, 07.2013, p. 927-934.

Research output: Contribution to journalArticle

Schneider, AG, Eastwood, GM, Bellomo, R, Bailey, M, Lipcsey, M, Pilcher, D, Young, P, Stow, P, Santamaria, J, Stachowski, E, Suzuki, S, Woinarski, NC & Pilcher, J 2013, 'Arterial carbon dioxide tension and outcome in patients admitted to the intensive care unit after cardiac arrest', Resuscitation, vol. 84, no. 7, pp. 927-934. https://doi.org/10.1016/j.resuscitation.2013.02.014
Schneider, Antoine G. ; Eastwood, Glenn M. ; Bellomo, Rinaldo ; Bailey, Michael ; Lipcsey, Miklos ; Pilcher, David ; Young, Paul ; Stow, Peter ; Santamaria, John ; Stachowski, Edward ; Suzuki, Satoshi ; Woinarski, Nicholas C. ; Pilcher, Janine. / Arterial carbon dioxide tension and outcome in patients admitted to the intensive care unit after cardiac arrest. In: Resuscitation. 2013 ; Vol. 84, No. 7. pp. 927-934.
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