Aromatic layered guanidines bind sequence-specifically to DNA minor groove with precise fit

Ryuuta Fukutomi, Aya Tanatani, Hiroki Kakuta, Nobuo Tomioka, Akiko Itai, Yuichi Hashimoto, Koichi Shudo, Hiroyuki Kagechika

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Tetraguanidines (1 and 2) with an aromatic multilayered structure exhibit potent binding to a specific site of DNAS with binding constants of the order of 107 M-1 as deduced from Scatchard analysis of ultrafiltration data and simulation of CD titration curves. NMR spectra of the complexes indicated that 1 and 2 bind DNAs sequence-specifically at the minor groove, as predicted by computational docking studies.

Original languageEnglish
Pages (from-to)6475-6478
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number36
DOIs
Publication statusPublished - Sep 1998
Externally publishedYes

Keywords

  • Guanidines
  • Molecular recognition
  • NMR
  • Nucleic acids

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Aromatic layered guanidines bind sequence-specifically to DNA minor groove with precise fit'. Together they form a unique fingerprint.

  • Cite this

    Fukutomi, R., Tanatani, A., Kakuta, H., Tomioka, N., Itai, A., Hashimoto, Y., Shudo, K., & Kagechika, H. (1998). Aromatic layered guanidines bind sequence-specifically to DNA minor groove with precise fit. Tetrahedron Letters, 39(36), 6475-6478. https://doi.org/10.1016/S0040-4039(98)01378-1