Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders

Shigeto Nagao, Osamu Yokota, Chikako Ikeda, Naoya Takeda, Hideki Ishizu, Shigetoshi Kuroda, Koichiro Sudo, Seishi Terada, Shigeo Murayama, Yosuke Uchitomi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

To study the relationship between neurodegenerative diseases including argyrophilic grain disease (AGD) and late-onset schizophrenia and delusional disorders (LOSD; onset ≥40 years of age), we pathologically examined 23 patients with LOSD, 71 age-matched normal controls, and 22 psychiatric disease controls (11 depression, six personality disorder, two bipolar disorders, and three neurotic disorders cases). In all LOSD cases (compared to age-matched normal controls), the frequencies of Lewy body disease (LBD), AGD, and corticobasal degeneration (CBD) were 26.1 % (11.3 %), 21.7 % (8.5 %), and 4.3 % (0.0 %), respectively. There was no case of pure Alzheimer's disease (AD). The total frequency of LBD, AGD, and CBD was significantly higher in LOSD cases than in normal controls. Argyrophilic grains were significantly more severe in LOSD than in controls, but were almost completely restricted to the limbic system and adjacent temporal cortex. In LOSD patients whose onset occurred at ≥65 years of age (versus age-matched normal controls), the frequencies of LBD and AGD were 36.4 % (19.4 %) and 36.4 % (8.3 %), respectively, and AGD was significantly more frequent in LOSD patients than in normal controls. In LOSD patients whose onset occurred at

Original languageEnglish
Pages (from-to)317-331
Number of pages15
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Volume264
Issue number4
DOIs
Publication statusPublished - 2014

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Paranoid Schizophrenia
Schizophrenia
Lewy Body Disease
Limbic System
Neurotic Disorders
Personality Disorders
Temporal Lobe
Bipolar Disorder
Neurodegenerative Diseases
Psychiatry
Late Onset Disorders
Alzheimer Disease
Depression

Keywords

  • Argyrophilic grain
  • Corticobasal degeneration
  • Four-repeat tau
  • Late onset
  • Tauopathy
  • α-Synuclein

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)
  • Medicine(all)

Cite this

Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders. / Nagao, Shigeto; Yokota, Osamu; Ikeda, Chikako; Takeda, Naoya; Ishizu, Hideki; Kuroda, Shigetoshi; Sudo, Koichiro; Terada, Seishi; Murayama, Shigeo; Uchitomi, Yosuke.

In: European Archives of Psychiatry and Clinical Neuroscience, Vol. 264, No. 4, 2014, p. 317-331.

Research output: Contribution to journalArticle

Nagao, Shigeto ; Yokota, Osamu ; Ikeda, Chikako ; Takeda, Naoya ; Ishizu, Hideki ; Kuroda, Shigetoshi ; Sudo, Koichiro ; Terada, Seishi ; Murayama, Shigeo ; Uchitomi, Yosuke. / Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders. In: European Archives of Psychiatry and Clinical Neuroscience. 2014 ; Vol. 264, No. 4. pp. 317-331.
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