Are glucocorticoids auto- and/or paracrine factors in early bovine embryo development and implantation?

Marta J. Siemieniuch, Magdalena Majewska, Masashi Takahashi, Miki Sakatani, Karolina Łukasik, Kiyoshi Okuda, Dariusz J. Skarzynski

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We determined the transcript content of three genes involved in the metabolism of glucocorticoids (GC) in bovine in vitro fertilized embryos (2-blastomere stage until hatched blastocyst), trophoblast as well as the oviduct (Day 2-4 of the estrous cycle) and endometrium (Day 16 of the cycle and pregnancy). Since mRNA expression of the glucocorticoid receptor and two enzymes responsible for GC production (11β-HSD1 and 2) was demonstrated in the embryos in all pre-implantation stages as well as in the endometrium and oviduct, it is suggested that GC may serve as auto-/paracrine factors in the development of bovine pre-implantation embryos.

Original languageEnglish
Pages (from-to)249-256
Number of pages8
JournalReproductive Biology
Volume10
Issue number3
DOIs
Publication statusPublished - Nov 2010

Keywords

  • Cattle
  • Embryo
  • Endometrium
  • Glucocorticoids
  • Oviduct
  • Trophoblast

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Endocrinology
  • Developmental Biology

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  • Cite this

    Siemieniuch, M. J., Majewska, M., Takahashi, M., Sakatani, M., Łukasik, K., Okuda, K., & Skarzynski, D. J. (2010). Are glucocorticoids auto- and/or paracrine factors in early bovine embryo development and implantation? Reproductive Biology, 10(3), 249-256. https://doi.org/10.1016/S1642-431X(12)60045-X