Are glucocorticoids auto- and/or paracrine factors in early bovine embryo development and implantation?

Marta J. Siemieniuch, Magdalena Majewska, Masashi Takahashi, Miki Sakatani, Karolina Łukasik, Kiyoshi Okuda, Dariusz J. Skarzynski

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We determined the transcript content of three genes involved in the metabolism of glucocorticoids (GC) in bovine in vitro fertilized embryos (2-blastomere stage until hatched blastocyst), trophoblast as well as the oviduct (Day 2-4 of the estrous cycle) and endometrium (Day 16 of the cycle and pregnancy). Since mRNA expression of the glucocorticoid receptor and two enzymes responsible for GC production (11β-HSD1 and 2) was demonstrated in the embryos in all pre-implantation stages as well as in the endometrium and oviduct, it is suggested that GC may serve as auto-/paracrine factors in the development of bovine pre-implantation embryos.

Original languageEnglish
Pages (from-to)249-256
Number of pages8
JournalReproductive biology
Volume10
Issue number3
Publication statusPublished - Nov 2010

Fingerprint

embryo implantation
glucocorticoids
automobiles
Glucocorticoids
Embryonic Development
embryogenesis
Oviducts
endometrium
Endometrium
oviducts
cattle
embryo (animal)
Embryonic Structures
Blastomeres
blastomeres
trophoblast
Estrous Cycle
Glucocorticoid Receptors
Trophoblasts
Blastocyst

Keywords

  • Cattle
  • Embryo
  • Endometrium
  • Glucocorticoids
  • Oviduct
  • Trophoblast

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Developmental Biology
  • Endocrinology

Cite this

Siemieniuch, M. J., Majewska, M., Takahashi, M., Sakatani, M., Łukasik, K., Okuda, K., & Skarzynski, D. J. (2010). Are glucocorticoids auto- and/or paracrine factors in early bovine embryo development and implantation? Reproductive biology, 10(3), 249-256.

Are glucocorticoids auto- and/or paracrine factors in early bovine embryo development and implantation? / Siemieniuch, Marta J.; Majewska, Magdalena; Takahashi, Masashi; Sakatani, Miki; Łukasik, Karolina; Okuda, Kiyoshi; Skarzynski, Dariusz J.

In: Reproductive biology, Vol. 10, No. 3, 11.2010, p. 249-256.

Research output: Contribution to journalArticle

Siemieniuch, MJ, Majewska, M, Takahashi, M, Sakatani, M, Łukasik, K, Okuda, K & Skarzynski, DJ 2010, 'Are glucocorticoids auto- and/or paracrine factors in early bovine embryo development and implantation?', Reproductive biology, vol. 10, no. 3, pp. 249-256.
Siemieniuch MJ, Majewska M, Takahashi M, Sakatani M, Łukasik K, Okuda K et al. Are glucocorticoids auto- and/or paracrine factors in early bovine embryo development and implantation? Reproductive biology. 2010 Nov;10(3):249-256.
Siemieniuch, Marta J. ; Majewska, Magdalena ; Takahashi, Masashi ; Sakatani, Miki ; Łukasik, Karolina ; Okuda, Kiyoshi ; Skarzynski, Dariusz J. / Are glucocorticoids auto- and/or paracrine factors in early bovine embryo development and implantation?. In: Reproductive biology. 2010 ; Vol. 10, No. 3. pp. 249-256.
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