Architectonics of cell subpopulations of peripheral blood in patients with autoimmune myocarditis

Clinical and pathogenetic aspects

Z. S. Shogenov, N. N. Kekenadze, S. E. Vorobyeva, M. P. Usik, T. Elbeik, K. A. Akhmedilova, E. E. Mamonova, Eiji Matsuura, M. A. Paltsev, S. V. Suchkov

Research output: Contribution to journalArticle

Abstract

Aim. To compare the most significant architectonic parameters of peripheral blood cell subpopulations in patients with different variants of an autoimmune myocarditis (AIM) course and their clinical value in therapeutic practice. Material and methods. Blood cell subpopulations were studied with flow cytometry in 99 blood samples from patients having different AIM variants and myocardiosclerosis as well as in 40 healthy donors. Results. Severe (malignant) AIM was characterized by growing indices of T-/B lymphocyte activation, expression of activation markers on the cells of both differentiation lines, disproportions in composition of subpopulations of the immunoregulatory cells, parallel rise in specific weight of dendritic cells, reduced intensity of apoptosis of autoreactive T-lymphocytes. In benign AIM marked immunopathology was not found. This group can be considered as a separate variant of AIM course necessitating an individual approach to planning pathogenetically sound therapeutic and rehabilitation measures. Conclusion. The study of activation markers expression on peripheral blood cells is superior to the study of endomyocardial biopsies providing a non-invasive method of immunodiagnosis.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalTerapevticheskiǐ arkhiv
Volume80
Issue number12
Publication statusPublished - 2008

Fingerprint

Myocarditis
Blood Cells
Immunologic Tests
Lymphocyte Activation
Dendritic Cells
Cell Differentiation
Flow Cytometry
B-Lymphocytes
Rehabilitation
Tissue Donors
Apoptosis
T-Lymphocytes
Biopsy
Weights and Measures
Therapeutics

Keywords

  • Autoimmunity
  • Cell subpopulations
  • Myocardiosclerosis
  • Myocarditis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Shogenov, Z. S., Kekenadze, N. N., Vorobyeva, S. E., Usik, M. P., Elbeik, T., Akhmedilova, K. A., ... Suchkov, S. V. (2008). Architectonics of cell subpopulations of peripheral blood in patients with autoimmune myocarditis: Clinical and pathogenetic aspects. Terapevticheskiǐ arkhiv, 80(12), 23-28.

Architectonics of cell subpopulations of peripheral blood in patients with autoimmune myocarditis : Clinical and pathogenetic aspects. / Shogenov, Z. S.; Kekenadze, N. N.; Vorobyeva, S. E.; Usik, M. P.; Elbeik, T.; Akhmedilova, K. A.; Mamonova, E. E.; Matsuura, Eiji; Paltsev, M. A.; Suchkov, S. V.

In: Terapevticheskiǐ arkhiv, Vol. 80, No. 12, 2008, p. 23-28.

Research output: Contribution to journalArticle

Shogenov, ZS, Kekenadze, NN, Vorobyeva, SE, Usik, MP, Elbeik, T, Akhmedilova, KA, Mamonova, EE, Matsuura, E, Paltsev, MA & Suchkov, SV 2008, 'Architectonics of cell subpopulations of peripheral blood in patients with autoimmune myocarditis: Clinical and pathogenetic aspects', Terapevticheskiǐ arkhiv, vol. 80, no. 12, pp. 23-28.
Shogenov ZS, Kekenadze NN, Vorobyeva SE, Usik MP, Elbeik T, Akhmedilova KA et al. Architectonics of cell subpopulations of peripheral blood in patients with autoimmune myocarditis: Clinical and pathogenetic aspects. Terapevticheskiǐ arkhiv. 2008;80(12):23-28.
Shogenov, Z. S. ; Kekenadze, N. N. ; Vorobyeva, S. E. ; Usik, M. P. ; Elbeik, T. ; Akhmedilova, K. A. ; Mamonova, E. E. ; Matsuura, Eiji ; Paltsev, M. A. ; Suchkov, S. V. / Architectonics of cell subpopulations of peripheral blood in patients with autoimmune myocarditis : Clinical and pathogenetic aspects. In: Terapevticheskiǐ arkhiv. 2008 ; Vol. 80, No. 12. pp. 23-28.
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AU - Akhmedilova, K. A.

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