Arachidonic acid and docosahexaenoic acid supplementation increases coronary flow velocity reserve in Japanese elderly individuals

H. Oe, T. Hozumi, E. Murata, H. Matsuura, K. Negishi, Y. Matsumura, S. Iwata, K. Ogawa, K. Sugioka, Y. Takemoto, K. Shimada, M. Yoshiyama, Y. Ishikura, Y. Kiso, J. Yoshikawa

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Arachidonic acid (ARA) and docosahexaenoic acid (DHA) are important components of phospholipids and cell membranes. There has, however, been no clinical report on the direct effects of ARA and DHA on coronary circulation. Objective: To evaluate the effects of ARA and DHA on coronary circulation using the measurement of coronary flow velocity reserve (CFVR) by transthoracic Doppler echocardiography (TTDE). Methods: A double-blind, placebo-matched study of 28 Japanese elderly individuals (19 men, mean age 65 years) conducted to compare the effects of polyunsaturated fatty acids (PUFA; ARA 240 mg/day, DHA 240 mg/day) and placebo on CFVR. Coronary flow velocity (CFV) of the left anterior descending coronary artery was measured at rest and during hyperaemia by TTDE to determine CFVR. Results: There were no significant differences in CFV at rest or during hyperaemia in CFVR at baseline in the two groups (PUFA versus placebo 17 (7 SD) versus 16 (6), 62 (20) versus 59 (12), and 3.85 (1.04) versus 3.98 (0.83) cm/s, respectively). After three months' supplementation, CFV during hyperaemia was significantly higher in the PUFA than in the placebo group (73 (19) versus 64 (12) cm/s, p

Original languageEnglish
Pages (from-to)316-321
Number of pages6
JournalHeart
Volume94
Issue number3
DOIs
Publication statusPublished - Mar 2008
Externally publishedYes

Fingerprint

Docosahexaenoic Acids
Arachidonic Acid
Hyperemia
Placebos
Coronary Circulation
Doppler Echocardiography
Echocardiography
Unsaturated Fatty Acids
Double-Blind Method
Phospholipids
Coronary Vessels
Cell Membrane

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Oe, H., Hozumi, T., Murata, E., Matsuura, H., Negishi, K., Matsumura, Y., ... Yoshikawa, J. (2008). Arachidonic acid and docosahexaenoic acid supplementation increases coronary flow velocity reserve in Japanese elderly individuals. Heart, 94(3), 316-321. https://doi.org/10.1136/hrt.2006.113159

Arachidonic acid and docosahexaenoic acid supplementation increases coronary flow velocity reserve in Japanese elderly individuals. / Oe, H.; Hozumi, T.; Murata, E.; Matsuura, H.; Negishi, K.; Matsumura, Y.; Iwata, S.; Ogawa, K.; Sugioka, K.; Takemoto, Y.; Shimada, K.; Yoshiyama, M.; Ishikura, Y.; Kiso, Y.; Yoshikawa, J.

In: Heart, Vol. 94, No. 3, 03.2008, p. 316-321.

Research output: Contribution to journalArticle

Oe, H, Hozumi, T, Murata, E, Matsuura, H, Negishi, K, Matsumura, Y, Iwata, S, Ogawa, K, Sugioka, K, Takemoto, Y, Shimada, K, Yoshiyama, M, Ishikura, Y, Kiso, Y & Yoshikawa, J 2008, 'Arachidonic acid and docosahexaenoic acid supplementation increases coronary flow velocity reserve in Japanese elderly individuals', Heart, vol. 94, no. 3, pp. 316-321. https://doi.org/10.1136/hrt.2006.113159
Oe, H. ; Hozumi, T. ; Murata, E. ; Matsuura, H. ; Negishi, K. ; Matsumura, Y. ; Iwata, S. ; Ogawa, K. ; Sugioka, K. ; Takemoto, Y. ; Shimada, K. ; Yoshiyama, M. ; Ishikura, Y. ; Kiso, Y. ; Yoshikawa, J. / Arachidonic acid and docosahexaenoic acid supplementation increases coronary flow velocity reserve in Japanese elderly individuals. In: Heart. 2008 ; Vol. 94, No. 3. pp. 316-321.
@article{303d4afe71a746b592b7283fb6ee94f8,
title = "Arachidonic acid and docosahexaenoic acid supplementation increases coronary flow velocity reserve in Japanese elderly individuals",
abstract = "Background: Arachidonic acid (ARA) and docosahexaenoic acid (DHA) are important components of phospholipids and cell membranes. There has, however, been no clinical report on the direct effects of ARA and DHA on coronary circulation. Objective: To evaluate the effects of ARA and DHA on coronary circulation using the measurement of coronary flow velocity reserve (CFVR) by transthoracic Doppler echocardiography (TTDE). Methods: A double-blind, placebo-matched study of 28 Japanese elderly individuals (19 men, mean age 65 years) conducted to compare the effects of polyunsaturated fatty acids (PUFA; ARA 240 mg/day, DHA 240 mg/day) and placebo on CFVR. Coronary flow velocity (CFV) of the left anterior descending coronary artery was measured at rest and during hyperaemia by TTDE to determine CFVR. Results: There were no significant differences in CFV at rest or during hyperaemia in CFVR at baseline in the two groups (PUFA versus placebo 17 (7 SD) versus 16 (6), 62 (20) versus 59 (12), and 3.85 (1.04) versus 3.98 (0.83) cm/s, respectively). After three months' supplementation, CFV during hyperaemia was significantly higher in the PUFA than in the placebo group (73 (19) versus 64 (12) cm/s, p",
author = "H. Oe and T. Hozumi and E. Murata and H. Matsuura and K. Negishi and Y. Matsumura and S. Iwata and K. Ogawa and K. Sugioka and Y. Takemoto and K. Shimada and M. Yoshiyama and Y. Ishikura and Y. Kiso and J. Yoshikawa",
year = "2008",
month = "3",
doi = "10.1136/hrt.2006.113159",
language = "English",
volume = "94",
pages = "316--321",
journal = "Heart",
issn = "1355-6037",
publisher = "BMJ Publishing Group",
number = "3",

}

TY - JOUR

T1 - Arachidonic acid and docosahexaenoic acid supplementation increases coronary flow velocity reserve in Japanese elderly individuals

AU - Oe, H.

AU - Hozumi, T.

AU - Murata, E.

AU - Matsuura, H.

AU - Negishi, K.

AU - Matsumura, Y.

AU - Iwata, S.

AU - Ogawa, K.

AU - Sugioka, K.

AU - Takemoto, Y.

AU - Shimada, K.

AU - Yoshiyama, M.

AU - Ishikura, Y.

AU - Kiso, Y.

AU - Yoshikawa, J.

PY - 2008/3

Y1 - 2008/3

N2 - Background: Arachidonic acid (ARA) and docosahexaenoic acid (DHA) are important components of phospholipids and cell membranes. There has, however, been no clinical report on the direct effects of ARA and DHA on coronary circulation. Objective: To evaluate the effects of ARA and DHA on coronary circulation using the measurement of coronary flow velocity reserve (CFVR) by transthoracic Doppler echocardiography (TTDE). Methods: A double-blind, placebo-matched study of 28 Japanese elderly individuals (19 men, mean age 65 years) conducted to compare the effects of polyunsaturated fatty acids (PUFA; ARA 240 mg/day, DHA 240 mg/day) and placebo on CFVR. Coronary flow velocity (CFV) of the left anterior descending coronary artery was measured at rest and during hyperaemia by TTDE to determine CFVR. Results: There were no significant differences in CFV at rest or during hyperaemia in CFVR at baseline in the two groups (PUFA versus placebo 17 (7 SD) versus 16 (6), 62 (20) versus 59 (12), and 3.85 (1.04) versus 3.98 (0.83) cm/s, respectively). After three months' supplementation, CFV during hyperaemia was significantly higher in the PUFA than in the placebo group (73 (19) versus 64 (12) cm/s, p

AB - Background: Arachidonic acid (ARA) and docosahexaenoic acid (DHA) are important components of phospholipids and cell membranes. There has, however, been no clinical report on the direct effects of ARA and DHA on coronary circulation. Objective: To evaluate the effects of ARA and DHA on coronary circulation using the measurement of coronary flow velocity reserve (CFVR) by transthoracic Doppler echocardiography (TTDE). Methods: A double-blind, placebo-matched study of 28 Japanese elderly individuals (19 men, mean age 65 years) conducted to compare the effects of polyunsaturated fatty acids (PUFA; ARA 240 mg/day, DHA 240 mg/day) and placebo on CFVR. Coronary flow velocity (CFV) of the left anterior descending coronary artery was measured at rest and during hyperaemia by TTDE to determine CFVR. Results: There were no significant differences in CFV at rest or during hyperaemia in CFVR at baseline in the two groups (PUFA versus placebo 17 (7 SD) versus 16 (6), 62 (20) versus 59 (12), and 3.85 (1.04) versus 3.98 (0.83) cm/s, respectively). After three months' supplementation, CFV during hyperaemia was significantly higher in the PUFA than in the placebo group (73 (19) versus 64 (12) cm/s, p

UR - http://www.scopus.com/inward/record.url?scp=39749095020&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=39749095020&partnerID=8YFLogxK

U2 - 10.1136/hrt.2006.113159

DO - 10.1136/hrt.2006.113159

M3 - Article

VL - 94

SP - 316

EP - 321

JO - Heart

JF - Heart

SN - 1355-6037

IS - 3

ER -