Abstract
Transposable elements (TEs) are prevalent in most eukaryotes, and host genomes have devised silencing strategies to rein in TE activity. One of these, transcriptional silencing, is generally associated with DNA methylation and short interfering RNAs. Here we show that the Arabidopsis genes MAIL1 and MAIN define an alternative silencing pathway independent of DNA methylation and short interfering RNAs. Mutants for MAIL1 or MAIN exhibit release of silencing and appear to show impaired condensation of pericentromeric heterochromatin. Phylogenetic analysis suggests not only that MAIL1 and MAIN encode a retrotransposonrelated plant mobile domain, but also that host plant mobile domains were captured by DNA transposons during plant evolution. Our results reveal a role for Arabidopsis proteins with a transposon-related domain in gene silencing.
| Original language | English |
|---|---|
| Article number | 15122 |
| Journal | Nature Communications |
| Volume | 8 |
| DOIs | |
| Publication status | Published - Jan 1 2017 |
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ASJC Scopus subject areas
- Chemistry(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Physics and Astronomy(all)
Cite this
Arabidopsis proteins with a transposon-related domain act in gene silencing. / Ikeda, Yoko; Pélissier, Thierry; Bourguet, Pierre; Becker, Claude; Pouch-Pélissier, Marie Noëlle; Pogorelcnik, Romain; Weingartner, Magdalena; Weigel, Detlef; Deragon, Jean Marc; Mathieu, Olivier.
In: Nature Communications, Vol. 8, 15122, 01.01.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Arabidopsis proteins with a transposon-related domain act in gene silencing
AU - Ikeda, Yoko
AU - Pélissier, Thierry
AU - Bourguet, Pierre
AU - Becker, Claude
AU - Pouch-Pélissier, Marie Noëlle
AU - Pogorelcnik, Romain
AU - Weingartner, Magdalena
AU - Weigel, Detlef
AU - Deragon, Jean Marc
AU - Mathieu, Olivier
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Transposable elements (TEs) are prevalent in most eukaryotes, and host genomes have devised silencing strategies to rein in TE activity. One of these, transcriptional silencing, is generally associated with DNA methylation and short interfering RNAs. Here we show that the Arabidopsis genes MAIL1 and MAIN define an alternative silencing pathway independent of DNA methylation and short interfering RNAs. Mutants for MAIL1 or MAIN exhibit release of silencing and appear to show impaired condensation of pericentromeric heterochromatin. Phylogenetic analysis suggests not only that MAIL1 and MAIN encode a retrotransposonrelated plant mobile domain, but also that host plant mobile domains were captured by DNA transposons during plant evolution. Our results reveal a role for Arabidopsis proteins with a transposon-related domain in gene silencing.
AB - Transposable elements (TEs) are prevalent in most eukaryotes, and host genomes have devised silencing strategies to rein in TE activity. One of these, transcriptional silencing, is generally associated with DNA methylation and short interfering RNAs. Here we show that the Arabidopsis genes MAIL1 and MAIN define an alternative silencing pathway independent of DNA methylation and short interfering RNAs. Mutants for MAIL1 or MAIN exhibit release of silencing and appear to show impaired condensation of pericentromeric heterochromatin. Phylogenetic analysis suggests not only that MAIL1 and MAIN encode a retrotransposonrelated plant mobile domain, but also that host plant mobile domains were captured by DNA transposons during plant evolution. Our results reveal a role for Arabidopsis proteins with a transposon-related domain in gene silencing.
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UR - http://www.scopus.com/inward/citedby.url?scp=85033673000&partnerID=8YFLogxK
U2 - 10.1038/ncomms15122
DO - 10.1038/ncomms15122
M3 - Article
C2 - 28466841
AN - SCOPUS:85033673000
VL - 8
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 15122
ER -