Arabidopsis proteins with a transposon-related domain act in gene silencing

Yoko Ikeda, Thierry Pélissier, Pierre Bourguet, Claude Becker, Marie Noëlle Pouch-Pélissier, Romain Pogorelcnik, Magdalena Weingartner, Detlef Weigel, Jean Marc Deragon, Olivier Mathieu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Transposable elements (TEs) are prevalent in most eukaryotes, and host genomes have devised silencing strategies to rein in TE activity. One of these, transcriptional silencing, is generally associated with DNA methylation and short interfering RNAs. Here we show that the Arabidopsis genes MAIL1 and MAIN define an alternative silencing pathway independent of DNA methylation and short interfering RNAs. Mutants for MAIL1 or MAIN exhibit release of silencing and appear to show impaired condensation of pericentromeric heterochromatin. Phylogenetic analysis suggests not only that MAIL1 and MAIN encode a retrotransposonrelated plant mobile domain, but also that host plant mobile domains were captured by DNA transposons during plant evolution. Our results reveal a role for Arabidopsis proteins with a transposon-related domain in gene silencing.

Original languageEnglish
Article number15122
JournalNature Communications
Volume8
DOIs
Publication statusPublished - Jan 1 2017

Fingerprint

Arabidopsis Proteins
DNA Transposable Elements
Gene Silencing
genes
methylation
deoxyribonucleic acid
Genes
DNA Methylation
proteins
Small Interfering RNA
eukaryotes
Heterochromatin
genome
Eukaryota
Arabidopsis
Condensation
condensation
Genome

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Ikeda, Y., Pélissier, T., Bourguet, P., Becker, C., Pouch-Pélissier, M. N., Pogorelcnik, R., ... Mathieu, O. (2017). Arabidopsis proteins with a transposon-related domain act in gene silencing. Nature Communications, 8, [15122]. https://doi.org/10.1038/ncomms15122

Arabidopsis proteins with a transposon-related domain act in gene silencing. / Ikeda, Yoko; Pélissier, Thierry; Bourguet, Pierre; Becker, Claude; Pouch-Pélissier, Marie Noëlle; Pogorelcnik, Romain; Weingartner, Magdalena; Weigel, Detlef; Deragon, Jean Marc; Mathieu, Olivier.

In: Nature Communications, Vol. 8, 15122, 01.01.2017.

Research output: Contribution to journalArticle

Ikeda, Y, Pélissier, T, Bourguet, P, Becker, C, Pouch-Pélissier, MN, Pogorelcnik, R, Weingartner, M, Weigel, D, Deragon, JM & Mathieu, O 2017, 'Arabidopsis proteins with a transposon-related domain act in gene silencing', Nature Communications, vol. 8, 15122. https://doi.org/10.1038/ncomms15122
Ikeda Y, Pélissier T, Bourguet P, Becker C, Pouch-Pélissier MN, Pogorelcnik R et al. Arabidopsis proteins with a transposon-related domain act in gene silencing. Nature Communications. 2017 Jan 1;8. 15122. https://doi.org/10.1038/ncomms15122
Ikeda, Yoko ; Pélissier, Thierry ; Bourguet, Pierre ; Becker, Claude ; Pouch-Pélissier, Marie Noëlle ; Pogorelcnik, Romain ; Weingartner, Magdalena ; Weigel, Detlef ; Deragon, Jean Marc ; Mathieu, Olivier. / Arabidopsis proteins with a transposon-related domain act in gene silencing. In: Nature Communications. 2017 ; Vol. 8.
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