TY - JOUR
T1 - Aquaporin-1 (AQP1) is expressed in the stria vascularis of rat cochlea
AU - Sawada, Shoichi
AU - Takeda, Taizo
AU - Kitano, Hiroya
AU - Takeuchi, Shunji
AU - Okada, Teruhiko
AU - Ando, Motonori
AU - Suzuki, Mikio
AU - Kakigi, Akinobu
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2003/7
Y1 - 2003/7
N2 - Cochlea endolymph, produced by the stria vascularis, is essential for normal inner ear function. Abnormal endolymphatic volumes correlate closely with pathological conditions such as Ménière's disease. The critical roles played by aquaporins, which facilitate osmotic movement of water molecules, are known in a variety of tissues. We investigated the expression of aquaporin-1 (AQP1) in the rat inner ear using reverse transcription polymerase chain reaction and immunohistochemical methods. We obtained novel data showing that not just AQP1 mRNA but also AQP1 protein is expressed in the stria vascularis, in addition to other data confirming previous reports. AQP1 immunoreactivity localized to the intermediate cells in the stria vascularis. The above finding suggests that AQP1 may play a role in the water distribution associated with vigorous ion transport in the stria vascularis since the intermediate part of the stria vascularis contains both intermediate cells and the basolateral parts of marginal cells, both of which express ion transporters abundantly.
AB - Cochlea endolymph, produced by the stria vascularis, is essential for normal inner ear function. Abnormal endolymphatic volumes correlate closely with pathological conditions such as Ménière's disease. The critical roles played by aquaporins, which facilitate osmotic movement of water molecules, are known in a variety of tissues. We investigated the expression of aquaporin-1 (AQP1) in the rat inner ear using reverse transcription polymerase chain reaction and immunohistochemical methods. We obtained novel data showing that not just AQP1 mRNA but also AQP1 protein is expressed in the stria vascularis, in addition to other data confirming previous reports. AQP1 immunoreactivity localized to the intermediate cells in the stria vascularis. The above finding suggests that AQP1 may play a role in the water distribution associated with vigorous ion transport in the stria vascularis since the intermediate part of the stria vascularis contains both intermediate cells and the basolateral parts of marginal cells, both of which express ion transporters abundantly.
KW - Endolymph
KW - Immunohistochemistry
KW - Polymerase chain reaction
KW - Water transport
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U2 - 10.1016/S0378-5955(03)00131-X
DO - 10.1016/S0378-5955(03)00131-X
M3 - Article
C2 - 12855358
AN - SCOPUS:0037677599
VL - 181
SP - 15
EP - 19
JO - Hearing Research
JF - Hearing Research
SN - 0378-5955
IS - 1-2
ER -