Aquaporin-1 (AQP1) is expressed in the stria vascularis of rat cochlea

Shoichi Sawada, Taizo Takeda, Hiroya Kitano, Shunji Takeuchi, Teruhiko Okada, Motonori Ando, Mikio Suzuki, Akinobu Kakigi

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Cochlea endolymph, produced by the stria vascularis, is essential for normal inner ear function. Abnormal endolymphatic volumes correlate closely with pathological conditions such as Ménière's disease. The critical roles played by aquaporins, which facilitate osmotic movement of water molecules, are known in a variety of tissues. We investigated the expression of aquaporin-1 (AQP1) in the rat inner ear using reverse transcription polymerase chain reaction and immunohistochemical methods. We obtained novel data showing that not just AQP1 mRNA but also AQP1 protein is expressed in the stria vascularis, in addition to other data confirming previous reports. AQP1 immunoreactivity localized to the intermediate cells in the stria vascularis. The above finding suggests that AQP1 may play a role in the water distribution associated with vigorous ion transport in the stria vascularis since the intermediate part of the stria vascularis contains both intermediate cells and the basolateral parts of marginal cells, both of which express ion transporters abundantly.

Original languageEnglish
Pages (from-to)15-19
Number of pages5
JournalHearing Research
Volume181
Issue number1-2
DOIs
Publication statusPublished - Jul 2003
Externally publishedYes

Keywords

  • Endolymph
  • Immunohistochemistry
  • Polymerase chain reaction
  • Water transport

ASJC Scopus subject areas

  • Sensory Systems

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