Appropriate parameters of the ordered-subset expectation maximization algorithm on measurement of myocardial blood flow and oxygen consumption with 11C-acetate PET

Masato Kobayashi, Tetsuya Mori, Yasushi Kiyono, Tetsuya Tsujikawa, Rikiya Maruyama, Yusuke Higaki, Naoto Shikano, Ryuichi Nishii, Keiichi Kawai, Takashi Kudo, Hidehiko Okazawa

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: The purpose of this study was to evaluate the appropriate parameters of a filter and of subsets (S) and iterations (I) of the ordered-subset expectation maximization (OSEM) algorithm in 11C- acetate PET. METHODS: A Hanning filter (HF) and a Gaussian filter (GF) were selected for filtered back-projection (FBP) and the OSEM algorithm, respectively. After evaluation of the optimal HF size, the GF size was optimized using healthy volunteers (HV). Myocardial blood flow (MBF) and oxygen consumption (k mono) values were calculated by combining 4S, 16S, or 28S with 2I, 4I, 6I, or 8I of the OSEM (MBFOSEM and k monoOSEM, respectively) in eight HV and eight coronary artery disease (CAD) patients. These MBFOSEM and k monoOSEM values were compared with those obtained using FBP (MBFFBP and k monoFBP, respectively). RESULTS: Optimal HF and GF (10.0GF) sizes for the FBP and OSEM algorithms, respectively, were 10.0 mm full-width resolution at half-maximum. MBF OSEM was changed by modifying the parameters of the OSEM algorithm. The best correlations were between MBFFBP and MBF OSEM, with 28S6I and 10.0GF for HV patients and 28S8I for CAD patients. However, the MBF OSEM with 28S8I was significantly different from MBFFBP at the global myocardium in HV. The k monoOSEM with 28S6I was not significantly different from k monoFBP in HV or CAD patients. CONCLUSION: Appropriate parameters are 28S6I with a 10.0GF on the MBF OSEM and k monoOSEM measurement using 11C-acetate. Diagnostic performance will improve using noiseless, artifact-reduction images, and accurate quantitative values that are provided by the OSEM algorithm with the appropriate parameters.

Original languageEnglish
Pages (from-to)130-138
Number of pages9
JournalNuclear Medicine Communications
Volume33
Issue number2
DOIs
Publication statusPublished - Feb 2012
Externally publishedYes

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Oxygen Consumption
Healthy Volunteers
Coronary Artery Disease
Artifacts
Myocardium
carbon-11 acetate

Keywords

  • C-acetate PET
  • cardiology
  • myocardial blood flow
  • myocardial oxygen consumption
  • ordered-subset expectation maximization

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Appropriate parameters of the ordered-subset expectation maximization algorithm on measurement of myocardial blood flow and oxygen consumption with 11C-acetate PET. / Kobayashi, Masato; Mori, Tetsuya; Kiyono, Yasushi; Tsujikawa, Tetsuya; Maruyama, Rikiya; Higaki, Yusuke; Shikano, Naoto; Nishii, Ryuichi; Kawai, Keiichi; Kudo, Takashi; Okazawa, Hidehiko.

In: Nuclear Medicine Communications, Vol. 33, No. 2, 02.2012, p. 130-138.

Research output: Contribution to journalArticle

Kobayashi, M, Mori, T, Kiyono, Y, Tsujikawa, T, Maruyama, R, Higaki, Y, Shikano, N, Nishii, R, Kawai, K, Kudo, T & Okazawa, H 2012, 'Appropriate parameters of the ordered-subset expectation maximization algorithm on measurement of myocardial blood flow and oxygen consumption with 11C-acetate PET', Nuclear Medicine Communications, vol. 33, no. 2, pp. 130-138. https://doi.org/10.1097/MNM.0b013e32834e7f5c
Kobayashi, Masato ; Mori, Tetsuya ; Kiyono, Yasushi ; Tsujikawa, Tetsuya ; Maruyama, Rikiya ; Higaki, Yusuke ; Shikano, Naoto ; Nishii, Ryuichi ; Kawai, Keiichi ; Kudo, Takashi ; Okazawa, Hidehiko. / Appropriate parameters of the ordered-subset expectation maximization algorithm on measurement of myocardial blood flow and oxygen consumption with 11C-acetate PET. In: Nuclear Medicine Communications. 2012 ; Vol. 33, No. 2. pp. 130-138.
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abstract = "OBJECTIVE: The purpose of this study was to evaluate the appropriate parameters of a filter and of subsets (S) and iterations (I) of the ordered-subset expectation maximization (OSEM) algorithm in 11C- acetate PET. METHODS: A Hanning filter (HF) and a Gaussian filter (GF) were selected for filtered back-projection (FBP) and the OSEM algorithm, respectively. After evaluation of the optimal HF size, the GF size was optimized using healthy volunteers (HV). Myocardial blood flow (MBF) and oxygen consumption (k mono) values were calculated by combining 4S, 16S, or 28S with 2I, 4I, 6I, or 8I of the OSEM (MBFOSEM and k monoOSEM, respectively) in eight HV and eight coronary artery disease (CAD) patients. These MBFOSEM and k monoOSEM values were compared with those obtained using FBP (MBFFBP and k monoFBP, respectively). RESULTS: Optimal HF and GF (10.0GF) sizes for the FBP and OSEM algorithms, respectively, were 10.0 mm full-width resolution at half-maximum. MBF OSEM was changed by modifying the parameters of the OSEM algorithm. The best correlations were between MBFFBP and MBF OSEM, with 28S6I and 10.0GF for HV patients and 28S8I for CAD patients. However, the MBF OSEM with 28S8I was significantly different from MBFFBP at the global myocardium in HV. The k monoOSEM with 28S6I was not significantly different from k monoFBP in HV or CAD patients. CONCLUSION: Appropriate parameters are 28S6I with a 10.0GF on the MBF OSEM and k monoOSEM measurement using 11C-acetate. Diagnostic performance will improve using noiseless, artifact-reduction images, and accurate quantitative values that are provided by the OSEM algorithm with the appropriate parameters.",
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author = "Masato Kobayashi and Tetsuya Mori and Yasushi Kiyono and Tetsuya Tsujikawa and Rikiya Maruyama and Yusuke Higaki and Naoto Shikano and Ryuichi Nishii and Keiichi Kawai and Takashi Kudo and Hidehiko Okazawa",
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T1 - Appropriate parameters of the ordered-subset expectation maximization algorithm on measurement of myocardial blood flow and oxygen consumption with 11C-acetate PET

AU - Kobayashi, Masato

AU - Mori, Tetsuya

AU - Kiyono, Yasushi

AU - Tsujikawa, Tetsuya

AU - Maruyama, Rikiya

AU - Higaki, Yusuke

AU - Shikano, Naoto

AU - Nishii, Ryuichi

AU - Kawai, Keiichi

AU - Kudo, Takashi

AU - Okazawa, Hidehiko

PY - 2012/2

Y1 - 2012/2

N2 - OBJECTIVE: The purpose of this study was to evaluate the appropriate parameters of a filter and of subsets (S) and iterations (I) of the ordered-subset expectation maximization (OSEM) algorithm in 11C- acetate PET. METHODS: A Hanning filter (HF) and a Gaussian filter (GF) were selected for filtered back-projection (FBP) and the OSEM algorithm, respectively. After evaluation of the optimal HF size, the GF size was optimized using healthy volunteers (HV). Myocardial blood flow (MBF) and oxygen consumption (k mono) values were calculated by combining 4S, 16S, or 28S with 2I, 4I, 6I, or 8I of the OSEM (MBFOSEM and k monoOSEM, respectively) in eight HV and eight coronary artery disease (CAD) patients. These MBFOSEM and k monoOSEM values were compared with those obtained using FBP (MBFFBP and k monoFBP, respectively). RESULTS: Optimal HF and GF (10.0GF) sizes for the FBP and OSEM algorithms, respectively, were 10.0 mm full-width resolution at half-maximum. MBF OSEM was changed by modifying the parameters of the OSEM algorithm. The best correlations were between MBFFBP and MBF OSEM, with 28S6I and 10.0GF for HV patients and 28S8I for CAD patients. However, the MBF OSEM with 28S8I was significantly different from MBFFBP at the global myocardium in HV. The k monoOSEM with 28S6I was not significantly different from k monoFBP in HV or CAD patients. CONCLUSION: Appropriate parameters are 28S6I with a 10.0GF on the MBF OSEM and k monoOSEM measurement using 11C-acetate. Diagnostic performance will improve using noiseless, artifact-reduction images, and accurate quantitative values that are provided by the OSEM algorithm with the appropriate parameters.

AB - OBJECTIVE: The purpose of this study was to evaluate the appropriate parameters of a filter and of subsets (S) and iterations (I) of the ordered-subset expectation maximization (OSEM) algorithm in 11C- acetate PET. METHODS: A Hanning filter (HF) and a Gaussian filter (GF) were selected for filtered back-projection (FBP) and the OSEM algorithm, respectively. After evaluation of the optimal HF size, the GF size was optimized using healthy volunteers (HV). Myocardial blood flow (MBF) and oxygen consumption (k mono) values were calculated by combining 4S, 16S, or 28S with 2I, 4I, 6I, or 8I of the OSEM (MBFOSEM and k monoOSEM, respectively) in eight HV and eight coronary artery disease (CAD) patients. These MBFOSEM and k monoOSEM values were compared with those obtained using FBP (MBFFBP and k monoFBP, respectively). RESULTS: Optimal HF and GF (10.0GF) sizes for the FBP and OSEM algorithms, respectively, were 10.0 mm full-width resolution at half-maximum. MBF OSEM was changed by modifying the parameters of the OSEM algorithm. The best correlations were between MBFFBP and MBF OSEM, with 28S6I and 10.0GF for HV patients and 28S8I for CAD patients. However, the MBF OSEM with 28S8I was significantly different from MBFFBP at the global myocardium in HV. The k monoOSEM with 28S6I was not significantly different from k monoFBP in HV or CAD patients. CONCLUSION: Appropriate parameters are 28S6I with a 10.0GF on the MBF OSEM and k monoOSEM measurement using 11C-acetate. Diagnostic performance will improve using noiseless, artifact-reduction images, and accurate quantitative values that are provided by the OSEM algorithm with the appropriate parameters.

KW - C-acetate PET

KW - cardiology

KW - myocardial blood flow

KW - myocardial oxygen consumption

KW - ordered-subset expectation maximization

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