Applications of Hadamard transform to gas chromatography/mass spectrometry and liquid chromatography/mass spectrometry

Cheng Huang Lin, Takashi Kaneta, Hung Ming Chen, Wen Xiong Chen, Hung Wei Chang, Ju Tsung Liu

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Successful application of the Hadamard transform (HT) technique to gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS) is described. Novel sample injection devices were developed to achieve multiple sample injections in both GC and LC instruments. Air pressure was controlled by an electromagnetic valve in GC, while a syringe pump and Tee connector were employed for the injection device in LC. Two well-known, abused drugs, 3,4-methylene-dioxy-N-methylamphetamine (MDMA) and N,N-dimethyltryptamine (DMT), were employed as model samples. Both of the injection devices permitted precise successive injections, resulting in clearly modulated chromatograms encoded by Hadamard matrices. After inverse Hadamard transformation of the encoded chromatogram, the signal-to-noise (S/N) ratios of the signals were substantially improved compared with those expected from theoretical values. The S/N ratios were enhanced ∼10-fold in HT-GC/MS and 6.8 in HT-LC/MS, using the matrices of 1023 and 511, respectively. The HT-GC/MS was successfully applied to the determination of MDMA in the urine sample of a suspect.

Original languageEnglish
Pages (from-to)5755-5759
Number of pages5
JournalAnalytical Chemistry
Volume80
Issue number15
DOIs
Publication statusPublished - Aug 1 2008
Externally publishedYes

Fingerprint

Hadamard transforms
Liquid chromatography
Gas chromatography
Mass spectrometry
Methamphetamine
Signal to noise ratio
N,N-Dimethyltryptamine
Hadamard matrices
Syringes
Pumps
Air
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Applications of Hadamard transform to gas chromatography/mass spectrometry and liquid chromatography/mass spectrometry. / Lin, Cheng Huang; Kaneta, Takashi; Chen, Hung Ming; Chen, Wen Xiong; Chang, Hung Wei; Liu, Ju Tsung.

In: Analytical Chemistry, Vol. 80, No. 15, 01.08.2008, p. 5755-5759.

Research output: Contribution to journalArticle

Lin, Cheng Huang ; Kaneta, Takashi ; Chen, Hung Ming ; Chen, Wen Xiong ; Chang, Hung Wei ; Liu, Ju Tsung. / Applications of Hadamard transform to gas chromatography/mass spectrometry and liquid chromatography/mass spectrometry. In: Analytical Chemistry. 2008 ; Vol. 80, No. 15. pp. 5755-5759.
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