Application of Terahertz absorption spectroscopy to evaluation of aging variation of medicine

Masaya Kawase; Tadashi Saito; Masafumi Ogawa; Hideki Uejima; Yasutoshi Hatsuda; Sonoyo Kawanishi; Yoshihiko Hirotani; Michiaki Myotoku; Kenji Ikeda; Hiroki Konishi; Ikumi Iga; Junji Yamakawa; Seizi Nishizawa; Kohji Yamamoto; Masahiko Tani

doi:10.2116/analsci.27.209

Application of Terahertz absorption spectroscopy to evaluation of aging variation of medicine

Masaya Kawase, Tadashi Saito, Masafumi Ogawa, Hideki Uejima, Yasutoshi Hatsuda, Sonoyo Kawanishi, Yoshihiko Hirotani, Michiaki Myotoku, Kenji Ikeda, Hiroki Konishi, Ikumi Iga, Junji Yamakawa, Seizi Nishizawa, Kohji Yamamoto, Masahiko Tani

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The absorption spectra of three kinds of medicines both before and after the expiration date: Amlodin OD® (5 mg), Basen OD® (0.2 mg) and Gaster D® (10 mg) have been measured by terahertz time domain spectroscopy (THz-TDS). All the medicines show some differences in the THz absorption spectra between medicines before and after the expiration dates. X-Ray powder diffraction (XRD) studies of all medicines suggest that the polymorph of the main effective compound is not changed before and after the expiration date. Therefore, the differences in the THz spectra between medicines before and after the expiration dates arise from aging variation of diluting agents and/or from modifications of intermolecular interaction between the effective compounds and diluting agents.

Original language	English
Pages (from-to)	209-212
Number of pages	4
Journal	Analytical Sciences
Volume	27
Issue number	2
DOIs	https://doi.org/10.2116/analsci.27.209
Publication status	Published - 2011

ASJC Scopus subject areas

Analytical Chemistry

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Application of Terahertz absorption spectroscopy to evaluation of aging variation of medicine. / Kawase, Masaya; Saito, Tadashi; Ogawa, Masafumi; Uejima, Hideki; Hatsuda, Yasutoshi; Kawanishi, Sonoyo; Hirotani, Yoshihiko; Myotoku, Michiaki; Ikeda, Kenji; Konishi, Hiroki; Iga, Ikumi; Yamakawa, Junji; Nishizawa, Seizi; Yamamoto, Kohji; Tani, Masahiko.

In: Analytical Sciences, Vol. 27, No. 2, 2011, p. 209-212.

Research output: Contribution to journal › Article › peer-review

Kawase, Masaya ; Saito, Tadashi ; Ogawa, Masafumi ; Uejima, Hideki ; Hatsuda, Yasutoshi ; Kawanishi, Sonoyo ; Hirotani, Yoshihiko ; Myotoku, Michiaki ; Ikeda, Kenji ; Konishi, Hiroki ; Iga, Ikumi ; Yamakawa, Junji ; Nishizawa, Seizi ; Yamamoto, Kohji ; Tani, Masahiko. / Application of Terahertz absorption spectroscopy to evaluation of aging variation of medicine. In: Analytical Sciences. 2011 ; Vol. 27, No. 2. pp. 209-212.

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title = "Application of Terahertz absorption spectroscopy to evaluation of aging variation of medicine",

abstract = "The absorption spectra of three kinds of medicines both before and after the expiration date: Amlodin OD{\textregistered} (5 mg), Basen OD{\textregistered} (0.2 mg) and Gaster D{\textregistered} (10 mg) have been measured by terahertz time domain spectroscopy (THz-TDS). All the medicines show some differences in the THz absorption spectra between medicines before and after the expiration dates. X-Ray powder diffraction (XRD) studies of all medicines suggest that the polymorph of the main effective compound is not changed before and after the expiration date. Therefore, the differences in the THz spectra between medicines before and after the expiration dates arise from aging variation of diluting agents and/or from modifications of intermolecular interaction between the effective compounds and diluting agents.",

author = "Masaya Kawase and Tadashi Saito and Masafumi Ogawa and Hideki Uejima and Yasutoshi Hatsuda and Sonoyo Kawanishi and Yoshihiko Hirotani and Michiaki Myotoku and Kenji Ikeda and Hiroki Konishi and Ikumi Iga and Junji Yamakawa and Seizi Nishizawa and Kohji Yamamoto and Masahiko Tani",

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AU - Kawase, Masaya

AU - Saito, Tadashi

AU - Ogawa, Masafumi

AU - Uejima, Hideki

AU - Hatsuda, Yasutoshi

AU - Kawanishi, Sonoyo

AU - Hirotani, Yoshihiko

AU - Myotoku, Michiaki

AU - Ikeda, Kenji

AU - Konishi, Hiroki

AU - Iga, Ikumi

AU - Yamakawa, Junji

AU - Nishizawa, Seizi

AU - Yamamoto, Kohji

AU - Tani, Masahiko

PY - 2011

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AB - The absorption spectra of three kinds of medicines both before and after the expiration date: Amlodin OD® (5 mg), Basen OD® (0.2 mg) and Gaster D® (10 mg) have been measured by terahertz time domain spectroscopy (THz-TDS). All the medicines show some differences in the THz absorption spectra between medicines before and after the expiration dates. X-Ray powder diffraction (XRD) studies of all medicines suggest that the polymorph of the main effective compound is not changed before and after the expiration date. Therefore, the differences in the THz spectra between medicines before and after the expiration dates arise from aging variation of diluting agents and/or from modifications of intermolecular interaction between the effective compounds and diluting agents.

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Application of Terahertz absorption spectroscopy to evaluation of aging variation of medicine

Abstract

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