Abstract
The absorption spectra of three kinds of medicines both before and after the expiration date: Amlodin OD® (5 mg), Basen OD® (0.2 mg) and Gaster D® (10 mg) have been measured by terahertz time domain spectroscopy (THz-TDS). All the medicines show some differences in the THz absorption spectra between medicines before and after the expiration dates. X-Ray powder diffraction (XRD) studies of all medicines suggest that the polymorph of the main effective compound is not changed before and after the expiration date. Therefore, the differences in the THz spectra between medicines before and after the expiration dates arise from aging variation of diluting agents and/or from modifications of intermolecular interaction between the effective compounds and diluting agents.
| Original language | English |
|---|---|
| Pages (from-to) | 209-212 |
| Number of pages | 4 |
| Journal | Analytical Sciences |
| Volume | 27 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2011 |
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ASJC Scopus subject areas
- Analytical Chemistry
Cite this
Application of Terahertz absorption spectroscopy to evaluation of aging variation of medicine. / Kawase, Masaya; Saito, Tadashi; Ogawa, Masafumi; Uejima, Hideki; Hatsuda, Yasutoshi; Kawanishi, Sonoyo; Hirotani, Yoshihiko; Myotoku, Michiaki; Ikeda, Kenji; Konishi, Hiroki; Iga, Ikumi; Yamakawa, Junji; Nishizawa, Seizi; Yamamoto, Kohji; Tani, Masahiko.
In: Analytical Sciences, Vol. 27, No. 2, 2011, p. 209-212.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Application of Terahertz absorption spectroscopy to evaluation of aging variation of medicine
AU - Kawase, Masaya
AU - Saito, Tadashi
AU - Ogawa, Masafumi
AU - Uejima, Hideki
AU - Hatsuda, Yasutoshi
AU - Kawanishi, Sonoyo
AU - Hirotani, Yoshihiko
AU - Myotoku, Michiaki
AU - Ikeda, Kenji
AU - Konishi, Hiroki
AU - Iga, Ikumi
AU - Yamakawa, Junji
AU - Nishizawa, Seizi
AU - Yamamoto, Kohji
AU - Tani, Masahiko
PY - 2011
Y1 - 2011
N2 - The absorption spectra of three kinds of medicines both before and after the expiration date: Amlodin OD® (5 mg), Basen OD® (0.2 mg) and Gaster D® (10 mg) have been measured by terahertz time domain spectroscopy (THz-TDS). All the medicines show some differences in the THz absorption spectra between medicines before and after the expiration dates. X-Ray powder diffraction (XRD) studies of all medicines suggest that the polymorph of the main effective compound is not changed before and after the expiration date. Therefore, the differences in the THz spectra between medicines before and after the expiration dates arise from aging variation of diluting agents and/or from modifications of intermolecular interaction between the effective compounds and diluting agents.
AB - The absorption spectra of three kinds of medicines both before and after the expiration date: Amlodin OD® (5 mg), Basen OD® (0.2 mg) and Gaster D® (10 mg) have been measured by terahertz time domain spectroscopy (THz-TDS). All the medicines show some differences in the THz absorption spectra between medicines before and after the expiration dates. X-Ray powder diffraction (XRD) studies of all medicines suggest that the polymorph of the main effective compound is not changed before and after the expiration date. Therefore, the differences in the THz spectra between medicines before and after the expiration dates arise from aging variation of diluting agents and/or from modifications of intermolecular interaction between the effective compounds and diluting agents.
UR - http://www.scopus.com/inward/record.url?scp=79951475566&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79951475566&partnerID=8YFLogxK
U2 - 10.2116/analsci.27.209
DO - 10.2116/analsci.27.209
M3 - Article
C2 - 21321447
AN - SCOPUS:79951475566
VL - 27
SP - 209
EP - 212
JO - Analytical Sciences
JF - Analytical Sciences
SN - 0910-6340
IS - 2
ER -