Application of Terahertz absorption spectroscopy to evaluation of aging variation of medicine

Masaya Kawase, Tadashi Saito, Masafumi Ogawa, Hideki Uejima, Yasutoshi Hatsuda, Sonoyo Kawanishi, Yoshihiko Hirotani, Michiaki Myotoku, Kenji Ikeda, Hiroki Konishi, Ikumi Iga, Junji Yamakawa, Seizi Nishizawa, Kohji Yamamoto, Masahiko Tani

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The absorption spectra of three kinds of medicines both before and after the expiration date: Amlodin OD® (5 mg), Basen OD® (0.2 mg) and Gaster D® (10 mg) have been measured by terahertz time domain spectroscopy (THz-TDS). All the medicines show some differences in the THz absorption spectra between medicines before and after the expiration dates. X-Ray powder diffraction (XRD) studies of all medicines suggest that the polymorph of the main effective compound is not changed before and after the expiration date. Therefore, the differences in the THz spectra between medicines before and after the expiration dates arise from aging variation of diluting agents and/or from modifications of intermolecular interaction between the effective compounds and diluting agents.

Original languageEnglish
Pages (from-to)209-212
Number of pages4
JournalAnalytical Sciences
Volume27
Issue number2
DOIs
Publication statusPublished - 2011

ASJC Scopus subject areas

  • Analytical Chemistry

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  • Cite this

    Kawase, M., Saito, T., Ogawa, M., Uejima, H., Hatsuda, Y., Kawanishi, S., Hirotani, Y., Myotoku, M., Ikeda, K., Konishi, H., Iga, I., Yamakawa, J., Nishizawa, S., Yamamoto, K., & Tani, M. (2011). Application of Terahertz absorption spectroscopy to evaluation of aging variation of medicine. Analytical Sciences, 27(2), 209-212. https://doi.org/10.2116/analsci.27.209