Application of dynamic contrast-enhanced MRI to differentiate malignant lymphoma from squamous cell carcinoma in the head and neck

Jun Ichi Asaumi; Yoshinobu Yanagi; Hironobu Konouchi; Miki Hisatomi; Hidenobu Matsuzaki; Kanji Kishi

doi:10.1016/j.oraloncology.2003.12.002

Application of dynamic contrast-enhanced MRI to differentiate malignant lymphoma from squamous cell carcinoma in the head and neck

Jun Ichi Asaumi, Yoshinobu Yanagi, Hironobu Konouchi, Miki Hisatomi, Hidenobu Matsuzaki, Kanji Kishi

Research output: Contribution to journal › Article › peer-review

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Abstract

Because malignant lymphoma, the second most common malignant tumor of the head and neck, and squamous cell carcinoma (SCC), the most common malignant tumor of the head and neck, require different treatments, it is important to be able to differentiate them. In the present study, we attempted to differentiate malignant lymphomas from SCCs using dynamic contrast-enhanced MRI (DCE-MRI). Seventeen lesions (in 8 cases) of malignant lymphoma and 30 cases of SCC were compared by DCE-MRI. Thirteen of 17 malignant lymphomas (76.5%) showed the maximum contrast index (CI) at 90-180 s, while 26 of 30 SCCs (86.7%) showed the maximum CI at a much faster 60-105 s. There was a statistically significant difference between SCC and malignant lymphoma in the time needed reach the maximum CI (p=0.0177). There was also significant difference between SCC and malignant lymphoma in their maximum CIs (p<0.001), with the maximum CIs of 29/30 SCCs (96.7%) above 2.0, while 12/17 malignant lymphomas (70.6%) showed CIs of less than 2.0. We consider these findings to be useful for distinguishing lymphomas from SCCs.

Original language	English
Pages (from-to)	579-584
Number of pages	6
Journal	Oral Oncology
Volume	40
Issue number	6
DOIs	https://doi.org/10.1016/j.oraloncology.2003.12.002
Publication status	Published - Jul 2004

Keywords

Contrast index curve
DCE-MRI
Head and neck
Lymphoma
Squamous cell carcinoma

ASJC Scopus subject areas

Oral Surgery
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.oraloncology.2003.12.002

Cite this

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title = "Application of dynamic contrast-enhanced MRI to differentiate malignant lymphoma from squamous cell carcinoma in the head and neck",

abstract = "Because malignant lymphoma, the second most common malignant tumor of the head and neck, and squamous cell carcinoma (SCC), the most common malignant tumor of the head and neck, require different treatments, it is important to be able to differentiate them. In the present study, we attempted to differentiate malignant lymphomas from SCCs using dynamic contrast-enhanced MRI (DCE-MRI). Seventeen lesions (in 8 cases) of malignant lymphoma and 30 cases of SCC were compared by DCE-MRI. Thirteen of 17 malignant lymphomas (76.5%) showed the maximum contrast index (CI) at 90-180 s, while 26 of 30 SCCs (86.7%) showed the maximum CI at a much faster 60-105 s. There was a statistically significant difference between SCC and malignant lymphoma in the time needed reach the maximum CI (p=0.0177). There was also significant difference between SCC and malignant lymphoma in their maximum CIs (p<0.001), with the maximum CIs of 29/30 SCCs (96.7%) above 2.0, while 12/17 malignant lymphomas (70.6%) showed CIs of less than 2.0. We consider these findings to be useful for distinguishing lymphomas from SCCs.",

keywords = "Contrast index curve, DCE-MRI, Head and neck, Lymphoma, Squamous cell carcinoma",

author = "Asaumi, {Jun Ichi} and Yoshinobu Yanagi and Hironobu Konouchi and Miki Hisatomi and Hidenobu Matsuzaki and Kanji Kishi",

note = "Funding Information: This work was supported by a Grant-in-Aid for Scientific Research on Priority Areas of Okayama University and Grant-in-Aid (14370603, 14771037, 14771038) for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan.",

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T1 - Application of dynamic contrast-enhanced MRI to differentiate malignant lymphoma from squamous cell carcinoma in the head and neck

AU - Asaumi, Jun Ichi

AU - Yanagi, Yoshinobu

AU - Konouchi, Hironobu

AU - Hisatomi, Miki

AU - Matsuzaki, Hidenobu

AU - Kishi, Kanji

N1 - Funding Information: This work was supported by a Grant-in-Aid for Scientific Research on Priority Areas of Okayama University and Grant-in-Aid (14370603, 14771037, 14771038) for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan.

PY - 2004/7

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N2 - Because malignant lymphoma, the second most common malignant tumor of the head and neck, and squamous cell carcinoma (SCC), the most common malignant tumor of the head and neck, require different treatments, it is important to be able to differentiate them. In the present study, we attempted to differentiate malignant lymphomas from SCCs using dynamic contrast-enhanced MRI (DCE-MRI). Seventeen lesions (in 8 cases) of malignant lymphoma and 30 cases of SCC were compared by DCE-MRI. Thirteen of 17 malignant lymphomas (76.5%) showed the maximum contrast index (CI) at 90-180 s, while 26 of 30 SCCs (86.7%) showed the maximum CI at a much faster 60-105 s. There was a statistically significant difference between SCC and malignant lymphoma in the time needed reach the maximum CI (p=0.0177). There was also significant difference between SCC and malignant lymphoma in their maximum CIs (p<0.001), with the maximum CIs of 29/30 SCCs (96.7%) above 2.0, while 12/17 malignant lymphomas (70.6%) showed CIs of less than 2.0. We consider these findings to be useful for distinguishing lymphomas from SCCs.

AB - Because malignant lymphoma, the second most common malignant tumor of the head and neck, and squamous cell carcinoma (SCC), the most common malignant tumor of the head and neck, require different treatments, it is important to be able to differentiate them. In the present study, we attempted to differentiate malignant lymphomas from SCCs using dynamic contrast-enhanced MRI (DCE-MRI). Seventeen lesions (in 8 cases) of malignant lymphoma and 30 cases of SCC were compared by DCE-MRI. Thirteen of 17 malignant lymphomas (76.5%) showed the maximum contrast index (CI) at 90-180 s, while 26 of 30 SCCs (86.7%) showed the maximum CI at a much faster 60-105 s. There was a statistically significant difference between SCC and malignant lymphoma in the time needed reach the maximum CI (p=0.0177). There was also significant difference between SCC and malignant lymphoma in their maximum CIs (p<0.001), with the maximum CIs of 29/30 SCCs (96.7%) above 2.0, while 12/17 malignant lymphomas (70.6%) showed CIs of less than 2.0. We consider these findings to be useful for distinguishing lymphomas from SCCs.

KW - Contrast index curve

KW - DCE-MRI

KW - Head and neck

KW - Lymphoma

KW - Squamous cell carcinoma

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Application of dynamic contrast-enhanced MRI to differentiate malignant lymphoma from squamous cell carcinoma in the head and neck

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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