Application of coenzyme Q10 for accelerating soft tissue wound healing after tooth extraction in rats

Toshiki Yoneda, Takaaki Tomofuji, Yuya Kawabata, Daisuke Ekuni, Tetsuji Azuma, Kota Kataoka, Muneyoshi Kunitomo, Manabu Morita

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Accelerating wound healing after tooth extraction is beneficial in dental treatment. Application of antioxidants, such as reduced coenzyme Q10 (rCoQ10), may promote wound healing after tooth extraction. In this study, we examined the effects of topical application of rCoQ10 on wound healing after tooth extraction in rats. After maxillary first molars were extracted, male Fischer 344 rats (8 weeks old) (n = 27) received topical application of ointment containing 5% rCoQ10 (experimental group) or control ointment (control group) to the sockets for 3 or 8 days (n = 6-7/group). At 3 days after extraction, the experimental group showed higher collagen density and lower numbers of polymorphonuclear leukocytes in the upper part of socket, as compared to the control group (p <0.05). Gene expression of interleukin-1β, tumor necrosis factor-α and nuclear factor-κB were also lower in the experimental group than in the control group (p <0.05). At 8 days after tooth extraction, there were no significant differences in collagen density, number of polymorphonuclear leukocytes and bone fill between the groups. Our results suggest that topical application of rCoQ10 promotes wound healing in the soft tissue of the alveolar socket, but that rCoQ10 has a limited effect on bone remodeling in rats.

Original languageEnglish
Pages (from-to)5756-5769
Number of pages14
JournalNutrients
Volume6
Issue number12
DOIs
Publication statusPublished - Dec 10 2014

Fingerprint

coenzyme Q10
Tooth Extraction
tissue repair
Wound Healing
teeth
topical application
rats
ointments
Control Groups
Ointments
collagen
neutrophils
Neutrophils
Collagen
bones
tumor necrosis factors
Bone Remodeling
Inbred F344 Rats
interleukin-1
Interleukin-1

Keywords

  • Alveolar socket
  • Coenzyme Q10
  • Inflammation
  • Wound healing

ASJC Scopus subject areas

  • Food Science

Cite this

Application of coenzyme Q10 for accelerating soft tissue wound healing after tooth extraction in rats. / Yoneda, Toshiki; Tomofuji, Takaaki; Kawabata, Yuya; Ekuni, Daisuke; Azuma, Tetsuji; Kataoka, Kota; Kunitomo, Muneyoshi; Morita, Manabu.

In: Nutrients, Vol. 6, No. 12, 10.12.2014, p. 5756-5769.

Research output: Contribution to journalArticle

Yoneda, Toshiki ; Tomofuji, Takaaki ; Kawabata, Yuya ; Ekuni, Daisuke ; Azuma, Tetsuji ; Kataoka, Kota ; Kunitomo, Muneyoshi ; Morita, Manabu. / Application of coenzyme Q10 for accelerating soft tissue wound healing after tooth extraction in rats. In: Nutrients. 2014 ; Vol. 6, No. 12. pp. 5756-5769.
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