Application of a numerical simulation to improve the separation efficiency of a sperm sorter

Toru Hyakutake, Yuki Hashimoto, Shinichiro Yanase, Koji Matsuura, Keiji Naruse

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

This paper describes a study in which numerical simulations were applied to improve the separation efficiency of a microfluidic-based sperm sorter. Initially, the motion of 31 sperm were modeled as a sinusoidal wave. The modeled sperm were expected to move while vibrating in the fluid within the microchannel. In this analysis, the number of sperm extracted at the outlet channel and the rate of movement of the highly motile sperm were obtained for a wide range of flow velocities within the microchannel. By varying the channel height, and the width and the position of the sperm-inlet channel, we confirmed that the separation efficiency was highly dependent on the fluid velocity within the channel. These results will be valuable for improving the device configuration, and might help to realize further improvements in efficiency in the future.

Original languageEnglish
Pages (from-to)25-33
Number of pages9
JournalBiomedical Microdevices
Volume11
Issue number1
DOIs
Publication statusPublished - 2009

Keywords

  • Human reproduction
  • Microfluid
  • Numerical simulation
  • Separation efficiency
  • Sperm sorter

ASJC Scopus subject areas

  • Biomedical Engineering
  • Molecular Biology

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