Apparent Mineralocorticoid Excess Manifested in An Elderly Patient with Hypothyroidism

Kenichi Inagaki; Fumio Otsuka; Hiroyuki Otani; Chikage Sato; Tomoko Miyoshi; Toshio Ogura; Hirofumi Makino

doi:10.1016/j.amjhyper.2006.06.012

Apparent Mineralocorticoid Excess Manifested in An Elderly Patient with Hypothyroidism

Kenichi Inagaki, Fumio Otsuka, Hiroyuki Otani, Chikage Sato, Tomoko Miyoshi, Toshio Ogura, Hirofumi Makino

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The syndrome of apparent mineralocorticoid excess (AME) is characterized by persistent hypertension and hypokalemia, which is caused by impaired inactivation of cortisol (F) to cortisone (E). The thyroid hormone has been known to influence the F to E conversion leading to efficacious inactivation of F into E. However, there have been no reports regarding the clinical manifestation of secondary AME due to hypothyroidism. Here we report an elderly patient who manifested AME, showing persistent hypertension with hypokalemia induced by primary hypothyroidism. Maintenance of euthyroid conditions ameliorated the concurrent AME and restored adrenal secretion of aldosterone after the recovery of the F to E shuttle. This case report would broaden our clinical recognition regarding acquired AME in relation to thyroid dysfunction.

Original language	English
Pages (from-to)	104-107
Number of pages	4
Journal	American Journal of Hypertension
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/j.amjhyper.2006.06.012
Publication status	Published - Jan 2007

Keywords

Apparent mineralocorticoid excess
aldosterone
hypertension
hypokalemia
hypothyroidism

ASJC Scopus subject areas

Internal Medicine

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10.1016/j.amjhyper.2006.06.012

Cite this

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abstract = "The syndrome of apparent mineralocorticoid excess (AME) is characterized by persistent hypertension and hypokalemia, which is caused by impaired inactivation of cortisol (F) to cortisone (E). The thyroid hormone has been known to influence the F to E conversion leading to efficacious inactivation of F into E. However, there have been no reports regarding the clinical manifestation of secondary AME due to hypothyroidism. Here we report an elderly patient who manifested AME, showing persistent hypertension with hypokalemia induced by primary hypothyroidism. Maintenance of euthyroid conditions ameliorated the concurrent AME and restored adrenal secretion of aldosterone after the recovery of the F to E shuttle. This case report would broaden our clinical recognition regarding acquired AME in relation to thyroid dysfunction.",

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AU - Inagaki, Kenichi

AU - Otsuka, Fumio

AU - Otani, Hiroyuki

AU - Sato, Chikage

AU - Miyoshi, Tomoko

AU - Ogura, Toshio

AU - Makino, Hirofumi

PY - 2007/1

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KW - Apparent mineralocorticoid excess

KW - aldosterone

KW - hypertension

KW - hypokalemia

KW - hypothyroidism

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Apparent Mineralocorticoid Excess Manifested in An Elderly Patient with Hypothyroidism

Abstract

Keywords

ASJC Scopus subject areas

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