Apparent Mineralocorticoid Excess Manifested in An Elderly Patient with Hypothyroidism

Kenichi Inagaki, Fumio Otsuka, Hiroyuki Otani, Chikage Sato, Tomoko Miyoshi, Toshio Ogura, Hirofumi Makino

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


The syndrome of apparent mineralocorticoid excess (AME) is characterized by persistent hypertension and hypokalemia, which is caused by impaired inactivation of cortisol (F) to cortisone (E). The thyroid hormone has been known to influence the F to E conversion leading to efficacious inactivation of F into E. However, there have been no reports regarding the clinical manifestation of secondary AME due to hypothyroidism. Here we report an elderly patient who manifested AME, showing persistent hypertension with hypokalemia induced by primary hypothyroidism. Maintenance of euthyroid conditions ameliorated the concurrent AME and restored adrenal secretion of aldosterone after the recovery of the F to E shuttle. This case report would broaden our clinical recognition regarding acquired AME in relation to thyroid dysfunction.

Original languageEnglish
Pages (from-to)104-107
Number of pages4
JournalAmerican Journal of Hypertension
Issue number1
Publication statusPublished - Jan 2007


  • Apparent mineralocorticoid excess
  • aldosterone
  • hypertension
  • hypokalemia
  • hypothyroidism

ASJC Scopus subject areas

  • Internal Medicine


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