Apoptotic injury in cultured human hepatocytes induced by HMG-CoA reductase inhibitors

Medicine & Life Sciences

• Simvastatin 68%
• Hydroxymethylglutaryl-CoA Reductase Inhibitors 67%
• Hepatocytes 58%
• Wounds and Injuries 33%
• Caspase 8 26%
• Caspase 9 26%
• 5-diphosphomevalonic acid 21%
• Caspase 3 20%
• 2-(2-methoxy-4-nitrophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H tetrazolium monosodium salt 19%
• geranylgeranyl pyrophosphate 18%
• cerivastatin 18%
• Cell Survival 17%
• Fluvastatin 16%
• Lovastatin 15%
• Pravastatin 15%
• 3-hydroxy-3-methylglutaryl-coenzyme A 15%
• Caspase Inhibitors 13%
• Atorvastatin 13%
• Messenger RNA 13%
• Annexin A5 12%
• DNA Fragmentation 12%
• Oxidoreductases 10%
• Cell Count 8%
• Cholesterol 8%
• Lipids 7%
• Enzymes 6%
• Liver 5%

Chemical Compounds

• Hydroxymethylglutaryl Coenzyme A Reductase Inhibitor 100%
• Apoptotic 79%
• Simvastatin 60%
• Cell Viability 27%
• Cerivastatin 26%
• Fluvastatin 23%
• Pravastatin 22%
• dUTP 21%
• Lovastatin 21%
• Atorvastatin 20%
• Mevalonate 19%
• Coenzyme A 17%
• Cholesterol 12%
• Enzyme Activity 11%