Aplyronines D-H from the sea hare Aplysia kurodai: Isolation, structures, and cytotoxicity

Makoto Ojika, Hideo Kigoshi, Kiyotake Suenaga, Yoshifumi Imamura, Kohji Yoshikawa, Takeshi Ishigaki, Akira Sakakura, Tsuyoshi Mutou, Kiyoyuki Yamada

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Five cytotoxic macrolides, aplyronines D-H (4-8), were isolated from the Japanese sea hare Aplysia kurodai. They are new congeners of the antitumor compound aplyronine A (1), which was previously isolated from the same organism. Their structures were determined by spectroscopic analysis (NMR and MS). The cytotoxicity of these new compounds was evaluated in comparison with that of aplyronines A-C (1-3), suggesting the importance of the 7-O-seryl ester group for mediating the potent cytotoxicity of aplyronines.

Original languageEnglish
Pages (from-to)982-987
Number of pages6
Issue number4
Publication statusPublished - Jan 28 2012
Externally publishedYes


  • Aplyronine
  • Cytotoxicity
  • Isolation
  • Marine natural product
  • Sea hare
  • Structure

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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