API2-MALT1 Fusion Gene in Colorectal Lymphoma

Sumie Takase Sakugawa, Tadashi Yoshino, Shigeo Nakamura, Hiroshi Inagaki, Yoshito Sadahira, Hirokazu Nakamine, Mitsukuni Okabe, Koichi Ichimura, Mitsune Tanimoto, Tadaatsu Akagi

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The API2-MALT1 fusion gene was originally identified from a t(11;18)(q21;q21) translocation, a specific chromosomal abnormality that is found in mucosa-associated lymphoid tissue (MALT) lymphoma. Gastric MALT lymphomas positive for the API2-MALT1 fusion gene do not respond to Helicobacter pylori-eradication therapy, but otherwise, the incidence and clinicopathological behavior of colorectal MALT lymphoma with this genetic abnormality are unclear. We examined the API2-MALT1 fusion by multiplex RT-PCR method in 47 cases of MALT lymphoma and 13 cases of diffuse large B-cell lymphoma and evaluated the relevance of API2-MALT1 positivity to the clinical and pathological features. The mean ages of MALT lymphoma and diffuse large B-cell lymphoma patients were 65 (range, 37-87 y) and 58 (range, 14-85 y) years, respectively. API2-MALT1 fusion genes were detected in seven cases (15%) of MALT lymphoma and one case (8%) of diffuse large B-cell lymphoma. In MALT lymphomas, the tumor size in API2-MALT1-positive cases was 62 ± 39 mm (mean ± SD), statistically larger than that in API2-MALT1-negative cases (25 ± 19 mm; P <.01). The API2-MALT1-positive cases demonstrated more advanced clinical stages and a male predominance, compared with API2-MALT1-negative cases. Thus, API2-MALT1-positive tumors should be cared for as a more aggressive subgroup and be followed for a longer time.

Original languageEnglish
Pages (from-to)1232-1241
Number of pages10
JournalModern Pathology
Volume16
Issue number12
DOIs
Publication statusPublished - Dec 2003

Fingerprint

Marginal Zone B-Cell Lymphoma
Gene Fusion
Lymphoma
Lymphoma, Large B-Cell, Diffuse
Multiplex Polymerase Chain Reaction
Gastric Mucosa
Helicobacter pylori
Chromosome Aberrations
Neoplasms
Incidence

Keywords

  • API2
  • Large intestine
  • MALT lymphoma
  • MALT1
  • RT-PCR

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Sakugawa, S. T., Yoshino, T., Nakamura, S., Inagaki, H., Sadahira, Y., Nakamine, H., ... Akagi, T. (2003). API2-MALT1 Fusion Gene in Colorectal Lymphoma. Modern Pathology, 16(12), 1232-1241. https://doi.org/10.1097/01.MP.0000097283.47637.58

API2-MALT1 Fusion Gene in Colorectal Lymphoma. / Sakugawa, Sumie Takase; Yoshino, Tadashi; Nakamura, Shigeo; Inagaki, Hiroshi; Sadahira, Yoshito; Nakamine, Hirokazu; Okabe, Mitsukuni; Ichimura, Koichi; Tanimoto, Mitsune; Akagi, Tadaatsu.

In: Modern Pathology, Vol. 16, No. 12, 12.2003, p. 1232-1241.

Research output: Contribution to journalArticle

Sakugawa, ST, Yoshino, T, Nakamura, S, Inagaki, H, Sadahira, Y, Nakamine, H, Okabe, M, Ichimura, K, Tanimoto, M & Akagi, T 2003, 'API2-MALT1 Fusion Gene in Colorectal Lymphoma', Modern Pathology, vol. 16, no. 12, pp. 1232-1241. https://doi.org/10.1097/01.MP.0000097283.47637.58
Sakugawa ST, Yoshino T, Nakamura S, Inagaki H, Sadahira Y, Nakamine H et al. API2-MALT1 Fusion Gene in Colorectal Lymphoma. Modern Pathology. 2003 Dec;16(12):1232-1241. https://doi.org/10.1097/01.MP.0000097283.47637.58
Sakugawa, Sumie Takase ; Yoshino, Tadashi ; Nakamura, Shigeo ; Inagaki, Hiroshi ; Sadahira, Yoshito ; Nakamine, Hirokazu ; Okabe, Mitsukuni ; Ichimura, Koichi ; Tanimoto, Mitsune ; Akagi, Tadaatsu. / API2-MALT1 Fusion Gene in Colorectal Lymphoma. In: Modern Pathology. 2003 ; Vol. 16, No. 12. pp. 1232-1241.
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