API2-MALT1 fusion defines a distinctive clinicopathologic subtype in pulmonary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue

Mitsukuni Okabe, Hiroshi Inagaki, Koichi Ohshima, Tadashi Yoshino, Chunmei Li, Tadaaki Eimoto, Ryuzo Ueda, Shigeo Nakamura

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Abstract

t(11;18)(q21;q21) is associated with mucosa-associated lymphoid tissue (MALT)-type lymphoma and results in API2-MALT1 fusion. However, its clinicopathologic significance remains unclarified. API2-MALT1 fusion is detected most frequently in MALT lymphomas primarily involving the lung. We therefore screened 51 cases of pulmonary MALT lymphoma for API2-MALT1 fusion, and studied its relationship with clinicopathologic factors including the immunohistochemical expression of BCL10, another MALT lymphoma-associated molecule. The API2-MALT1 fusion transcript was detected in 21 of 51 (41%) cases, and was correlated with the absence of any underlying autoimmune disease, and with a normal serum lactate dehydrogenase, a "typical" histology without marked plasmacytic differentiation or an increased number of large cells, and aberrant nuclear BCL10 expression. However, its prognostic impact was not identified in the limited follow-up (6 to 187 months, median 27). These data suggest that theAPI2-MALT1 fusion may be a causative gene abnormality unrelated to autoimmune disease. In addition, this alteration may define a homogeneous MALT lymphoma subtype that is clinically more indolent and histologically more "typical" Aberrant nuclear BCL10 expression may have a possible role as a tool to screen for this API2-MALT1 fusion. A largescale study with a long follow-up is necessary to establish the prognostic significance of API2-MALT1 fusion.

Original languageEnglish
Pages (from-to)1113-1122
Number of pages10
JournalAmerican Journal of Pathology
Volume162
Issue number4
Publication statusPublished - Apr 1 2003

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Marginal Zone B-Cell Lymphoma
Lung
Autoimmune Diseases
L-Lactate Dehydrogenase
Histology
Cell Count
Serum
Genes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

API2-MALT1 fusion defines a distinctive clinicopathologic subtype in pulmonary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. / Okabe, Mitsukuni; Inagaki, Hiroshi; Ohshima, Koichi; Yoshino, Tadashi; Li, Chunmei; Eimoto, Tadaaki; Ueda, Ryuzo; Nakamura, Shigeo.

In: American Journal of Pathology, Vol. 162, No. 4, 01.04.2003, p. 1113-1122.

Research output: Contribution to journalArticle

Okabe, Mitsukuni ; Inagaki, Hiroshi ; Ohshima, Koichi ; Yoshino, Tadashi ; Li, Chunmei ; Eimoto, Tadaaki ; Ueda, Ryuzo ; Nakamura, Shigeo. / API2-MALT1 fusion defines a distinctive clinicopathologic subtype in pulmonary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. In: American Journal of Pathology. 2003 ; Vol. 162, No. 4. pp. 1113-1122.
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