API2-MALT1 fusion defines a distinctive clinicopathologic subtype in pulmonary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue

Mitsukuni Okabe, Hiroshi Inagaki, Koichi Ohshima, Tadashi Yoshino, Chunmei Li, Tadaaki Eimoto, Ryuzo Ueda, Shigeo Nakamura

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

t(11;18)(q21;q21) is associated with mucosa-associated lymphoid tissue (MALT)-type lymphoma and results in API2-MALT1 fusion. However, its clinicopathologic significance remains unclarified. API2-MALT1 fusion is detected most frequently in MALT lymphomas primarily involving the lung. We therefore screened 51 cases of pulmonary MALT lymphoma for API2-MALT1 fusion, and studied its relationship with clinicopathologic factors including the immunohistochemical expression of BCL10, another MALT lymphoma-associated molecule. The API2-MALT1 fusion transcript was detected in 21 of 51 (41%) cases, and was correlated with the absence of any underlying autoimmune disease, and with a normal serum lactate dehydrogenase, a "typical" histology without marked plasmacytic differentiation or an increased number of large cells, and aberrant nuclear BCL10 expression. However, its prognostic impact was not identified in the limited follow-up (6 to 187 months, median 27). These data suggest that theAPI2-MALT1 fusion may be a causative gene abnormality unrelated to autoimmune disease. In addition, this alteration may define a homogeneous MALT lymphoma subtype that is clinically more indolent and histologically more "typical" Aberrant nuclear BCL10 expression may have a possible role as a tool to screen for this API2-MALT1 fusion. A largescale study with a long follow-up is necessary to establish the prognostic significance of API2-MALT1 fusion.

Original languageEnglish
Pages (from-to)1113-1122
Number of pages10
JournalAmerican Journal of Pathology
Volume162
Issue number4
DOIs
Publication statusPublished - Apr 1 2003

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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