Apatite containing aspartic acid for selective protein loading

M. Hafiz Uddin, T. Matsumoto, S. Ishihara, A. Nakahira, M. Okazaki, T. Sohmura

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Physico-chemical modifications of hydroxyapatite (HAp) materials are considered as pre-requisites for the development of new bioactive carrier materials for drug delivery and tissue engineering applications. Since acidic amino acids have well-documented affinities to both HAp and basic proteins, HAp modified by aspartic acid (Asp, acidic amino acid) might be one of the candidate substrates for a basic protein carrier. Here, we synthesized HAp in the presence of various concentrations of Asp and observed that HAp crystallinity and other physico-chemical properties were effectively modulated. Detailed studies indicated that Asp was not incorporated in the HAp crystal lattice, but rather was trapped in HAp crystals. Protein adsorption studies indicated that the HAp particles modified by Asp had a selective loading capacity for basic protein. Therefore, HAp particles containing Asp might have potential in drug delivery applications, especially as the carrier of basic proteins including bFGF and BMP.

Original languageEnglish
Pages (from-to)488-492
Number of pages5
JournalJournal of dental research
Volume89
Issue number5
DOIs
Publication statusPublished - May 1 2010
Externally publishedYes

Keywords

  • Aspartic acid
  • Drug delivery system
  • Hydroxyapatite
  • Protein loading.

ASJC Scopus subject areas

  • Dentistry(all)

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