Aortic vascular graft infection caused by Cardiobacterium valvarum

a case report

Hideharu Hagiya, Susumu Kokeguchi, Hiroko Ogawa, Tomohiro Terasaka, Kosuke Kimura, Koichi Waseda, Yoshihisa Hanayama, Kaori Oda, Hisatoshi Mori, Toru Miyoshi, Fumio Otsuka

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 53-year-old man with a past medical history of total arch replacement surgery and severe aortic regurgitation presented with a 1-month history of persistent general malaise, anorexia, body weight loss and night sweats. His recent history included gingival hyperplasia for 6 years, gingivitis after tooth extraction 3 years before, prolonged inflammatory status for 4 months, fundal hemorrhage and leg tenderness for 2 months. A pathogen was detected from blood culture, but conventional microbiological examination failed to identify the pathogen. The organism was eventually identified as Cardiobacterium valvarum by 16S rRNA analysis, and the patient was diagnosed with infective endocarditis and prosthetic vascular graft infection. The patient received intravenous antibiotic therapy using a combination of ceftriaxone and levofloxacin for 5 weeks and was discharged with a good clinical course. C. valvarum is a rare human pathogen in clinical settings. Only 10 cases have been reported to date worldwide, and therefore, the clinical characteristics of C. valvarum infection are not fully known. This is a first well-described case of C. valvarum infection in Japan, and further, a first report of aortic prosthetic vascular graft infection worldwide. Identification of C. valvarum is usually difficult due to its phenotypic characteristics, and molecular approaches would be required for both clinicians and microbiologists to facilitate more reliable diagnosis and uncover its clinical picture more clearly.

Original languageEnglish
Pages (from-to)804-809
Number of pages6
JournalJournal of Infection and Chemotherapy
Volume20
Issue number12
DOIs
Publication statusPublished - Dec 1 2014

Fingerprint

Cardiobacterium
Blood Vessels
Transplants
Infection
Gingival Hyperplasia
Tooth Extraction
Gingivitis
Levofloxacin
Aortic Valve Insufficiency
Ceftriaxone
Sweat
Anorexia
Endocarditis
Weight Loss
Leg
Japan
History
Body Weight
Hemorrhage
Anti-Bacterial Agents

Keywords

  • Aortic vascular graft
  • Cardiobacterium
  • Hyperglobulinemia
  • Infective aneurysm
  • Infective endocarditis
  • Septic embolism

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Aortic vascular graft infection caused by Cardiobacterium valvarum : a case report. / Hagiya, Hideharu; Kokeguchi, Susumu; Ogawa, Hiroko; Terasaka, Tomohiro; Kimura, Kosuke; Waseda, Koichi; Hanayama, Yoshihisa; Oda, Kaori; Mori, Hisatoshi; Miyoshi, Toru; Otsuka, Fumio.

In: Journal of Infection and Chemotherapy, Vol. 20, No. 12, 01.12.2014, p. 804-809.

Research output: Contribution to journalArticle

Hagiya, Hideharu ; Kokeguchi, Susumu ; Ogawa, Hiroko ; Terasaka, Tomohiro ; Kimura, Kosuke ; Waseda, Koichi ; Hanayama, Yoshihisa ; Oda, Kaori ; Mori, Hisatoshi ; Miyoshi, Toru ; Otsuka, Fumio. / Aortic vascular graft infection caused by Cardiobacterium valvarum : a case report. In: Journal of Infection and Chemotherapy. 2014 ; Vol. 20, No. 12. pp. 804-809.
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