Antiviral effect of sinefungin on in vitro growth of feline herpesvirus type 1

Yudai Kuroda, Haruka Yamagata, Michiko Nemoto, Kenji Inagaki, Takashi Tamura, Ken Maeda

Research output: Contribution to journalArticle

Abstract

Feline herpesvirus type 1 (FHV-1) causes a potentially fatal disease in cats. Through the use of virus inhibition and cytotoxicity assays, sinefungin, a nucleoside antibiotic, was assessed for its potential to inhibit the growth of FHV-1. Sinefungin inhibited in vitro growth of FHV-1 most significantly over other animal viruses, such as feline infectious peritonitis virus, equine herpesvirus, pseudorabies virus and feline calicivirus. Our results revealed that sinefungin specifically suppressed the replication of FHV-1 after its adsorption to the host feline kidney cells in a dose-dependent manner without obvious cytotoxicity to the host cells. This antibiotic can potentially offer a highly effective treatment for animals infected with FHV-1, providing alternative medication to currently available antiviral therapies.

Original languageEnglish
Pages (from-to)981-985
Number of pages5
JournalJournal of Antibiotics
Volume72
Issue number12
DOIs
Publication statusPublished - Dec 1 2019

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sinefungin
Herpesviridae
Felidae
Antiviral Agents
Growth
Feline Coronavirus
Feline Calicivirus
Cat Diseases
Anti-Bacterial Agents
Viruses
Suid Herpesvirus 1
Nucleosides
Adsorption
Horses
In Vitro Techniques

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Antiviral effect of sinefungin on in vitro growth of feline herpesvirus type 1. / Kuroda, Yudai; Yamagata, Haruka; Nemoto, Michiko; Inagaki, Kenji; Tamura, Takashi; Maeda, Ken.

In: Journal of Antibiotics, Vol. 72, No. 12, 01.12.2019, p. 981-985.

Research output: Contribution to journalArticle

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