Antiviral effect of sinefungin on in vitro growth of feline herpesvirus type 1

Yudai Kuroda, Haruka Yamagata, Michiko Nemoto, Kenji Inagaki, Takashi Tamura, Ken Maeda

Research output: Contribution to journalArticle

Abstract

Feline herpesvirus type 1 (FHV-1) causes a potentially fatal disease in cats. Through the use of virus inhibition and cytotoxicity assays, sinefungin, a nucleoside antibiotic, was assessed for its potential to inhibit the growth of FHV-1. Sinefungin inhibited in vitro growth of FHV-1 most significantly over other animal viruses, such as feline infectious peritonitis virus, equine herpesvirus, pseudorabies virus and feline calicivirus. Our results revealed that sinefungin specifically suppressed the replication of FHV-1 after its adsorption to the host feline kidney cells in a dose-dependent manner without obvious cytotoxicity to the host cells. This antibiotic can potentially offer a highly effective treatment for animals infected with FHV-1, providing alternative medication to currently available antiviral therapies.

Original languageEnglish
Pages (from-to)981-985
Number of pages5
JournalJournal of Antibiotics
Volume72
Issue number12
DOIs
Publication statusPublished - Dec 1 2019

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ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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