Antiulcer mechanism of action of rebamipide, a novel antiulcer compound, on diethyldithiocarbamate-induced antral gastric ulcers in rats

Keiki Ogino, Tatsuya Hobara, Hironobu Ishiyama, Katsuya Yamasaki, Haruo Kobayashi, Yukie Izumi, Shinji Oka

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

The mechanism of the inhibitory action of rebamipide, a new mucosal protective drug, was studied using rats with diethyldithiocarbamate-induced gastric antral ulcers. Rebamipide reduced ulcer formation and inhibited the elevation in lipid peroxide concentration in the gastric mucosa. Rebamipide inhibited both luminol- and lucigen-dependent chemiluminescence of neutrophils activated by formyl-methionyl-leucyl-phenylalanine. Rebamipide did not alter the reduction of cytochrome c induced by the xanthine-xanthine oxidase system or the NADPH-dependent micirosomal lipid peroxidation in the liver. These findings suggest that rebamipide prevents diethyldithiocarbamate-induced gastric ulcer formation by inhibiting neutrophil activation.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalEuropean Journal of Pharmacology
Volume212
Issue number1
DOIs
Publication statusPublished - Feb 25 1992
Externally publishedYes

Fingerprint

Ditiocarb
Stomach Ulcer
methionyl-leucyl-phenylalanine
Protective Agents
Luminol
Neutrophil Activation
Xanthine
Xanthine Oxidase
Lipid Peroxides
Gastric Mucosa
Luminescence
Cytochromes c
NADP
Lipid Peroxidation
Ulcer
Neutrophils
rebamipide
Antral
Liver

Keywords

  • Diethyldithiocarbamate-induced antral ulcer
  • Neutrophil
  • Rebamipide

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Antiulcer mechanism of action of rebamipide, a novel antiulcer compound, on diethyldithiocarbamate-induced antral gastric ulcers in rats. / Ogino, Keiki; Hobara, Tatsuya; Ishiyama, Hironobu; Yamasaki, Katsuya; Kobayashi, Haruo; Izumi, Yukie; Oka, Shinji.

In: European Journal of Pharmacology, Vol. 212, No. 1, 25.02.1992, p. 9-13.

Research output: Contribution to journalArticle

Ogino, Keiki ; Hobara, Tatsuya ; Ishiyama, Hironobu ; Yamasaki, Katsuya ; Kobayashi, Haruo ; Izumi, Yukie ; Oka, Shinji. / Antiulcer mechanism of action of rebamipide, a novel antiulcer compound, on diethyldithiocarbamate-induced antral gastric ulcers in rats. In: European Journal of Pharmacology. 1992 ; Vol. 212, No. 1. pp. 9-13.
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