Antitumour effects of streptococcal lipoteichoic acids on meth a fibrosarcoma

H. Usami; A. Yamamoto; W. Yamashita; Y. Sugawara; S. Hamada; T. Yamamoto; K. Kato; S. Kokeguchi; H. Ohokuni; S. Kotani

doi:10.1038/bjc.1988.11

Antitumour effects of streptococcal lipoteichoic acids on meth a fibrosarcoma

H. Usami, A. Yamamoto, W. Yamashita, Y. Sugawara, S. Hamada, T. Yamamoto, K. Kato, S. Kokeguchi, H. Ohokuni, S. Kotani

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

The antitumour effects of lipoteichoic acids (LTA) extracted from Streptococcus pyogenes were studied in comparison with other streptococcal cellular components. LTA suppressed the tumour growth of both solid- and ascites-type MethA fibrosarcoma as did the whole cells of S. pyogenes (OK-432). No other cellular components, such as cell wall peptidoglycan, group-specific C-carbohydrate or type-specific M protein, suppressed the growth of MethA. LTA, but not the other cellular components, induced tumour necrosis factor (TNF) in Propionibacterium acnes-primed mice. LTA had no direct killing effects on MethA cells. These results indicate that LTA may be an important antitumour component of OK-432 and that one of the antitumour mechanisms by this streptococcal preparation is the induction of TNF.

Original language	English
Pages (from-to)	70-73
Number of pages	4
Journal	British Journal of Cancer
Volume	57
Issue number	1
DOIs	https://doi.org/10.1038/bjc.1988.11
Publication status	Published - Jan 1988

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/bjc.1988.11

Cite this

@article{2d83a490808146d1b2f1892bc8096c54,

title = "Antitumour effects of streptococcal lipoteichoic acids on meth a fibrosarcoma",

abstract = "The antitumour effects of lipoteichoic acids (LTA) extracted from Streptococcus pyogenes were studied in comparison with other streptococcal cellular components. LTA suppressed the tumour growth of both solid- and ascites-type MethA fibrosarcoma as did the whole cells of S. pyogenes (OK-432). No other cellular components, such as cell wall peptidoglycan, group-specific C-carbohydrate or type-specific M protein, suppressed the growth of MethA. LTA, but not the other cellular components, induced tumour necrosis factor (TNF) in Propionibacterium acnes-primed mice. LTA had no direct killing effects on MethA cells. These results indicate that LTA may be an important antitumour component of OK-432 and that one of the antitumour mechanisms by this streptococcal preparation is the induction of TNF.",

author = "H. Usami and A. Yamamoto and W. Yamashita and Y. Sugawara and S. Hamada and T. Yamamoto and K. Kato and S. Kokeguchi and H. Ohokuni and S. Kotani",

year = "1988",

month = jan,

doi = "10.1038/bjc.1988.11",

language = "English",

volume = "57",

pages = "70--73",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - Antitumour effects of streptococcal lipoteichoic acids on meth a fibrosarcoma

AU - Usami, H.

AU - Yamamoto, A.

AU - Yamashita, W.

AU - Sugawara, Y.

AU - Hamada, S.

AU - Yamamoto, T.

AU - Kato, K.

AU - Kokeguchi, S.

AU - Ohokuni, H.

AU - Kotani, S.

PY - 1988/1

Y1 - 1988/1

N2 - The antitumour effects of lipoteichoic acids (LTA) extracted from Streptococcus pyogenes were studied in comparison with other streptococcal cellular components. LTA suppressed the tumour growth of both solid- and ascites-type MethA fibrosarcoma as did the whole cells of S. pyogenes (OK-432). No other cellular components, such as cell wall peptidoglycan, group-specific C-carbohydrate or type-specific M protein, suppressed the growth of MethA. LTA, but not the other cellular components, induced tumour necrosis factor (TNF) in Propionibacterium acnes-primed mice. LTA had no direct killing effects on MethA cells. These results indicate that LTA may be an important antitumour component of OK-432 and that one of the antitumour mechanisms by this streptococcal preparation is the induction of TNF.

AB - The antitumour effects of lipoteichoic acids (LTA) extracted from Streptococcus pyogenes were studied in comparison with other streptococcal cellular components. LTA suppressed the tumour growth of both solid- and ascites-type MethA fibrosarcoma as did the whole cells of S. pyogenes (OK-432). No other cellular components, such as cell wall peptidoglycan, group-specific C-carbohydrate or type-specific M protein, suppressed the growth of MethA. LTA, but not the other cellular components, induced tumour necrosis factor (TNF) in Propionibacterium acnes-primed mice. LTA had no direct killing effects on MethA cells. These results indicate that LTA may be an important antitumour component of OK-432 and that one of the antitumour mechanisms by this streptococcal preparation is the induction of TNF.

UR - http://www.scopus.com/inward/record.url?scp=0023829927&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023829927&partnerID=8YFLogxK

U2 - 10.1038/bjc.1988.11

DO - 10.1038/bjc.1988.11

M3 - Article

C2 - 3279996

AN - SCOPUS:0023829927

SN - 0007-0920

VL - 57

SP - 70

EP - 73

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 1

ER -

Antitumour effects of streptococcal lipoteichoic acids on meth a fibrosarcoma

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this