Antitumour effects of streptococcal lipoteichoic acids on Meth A fibrosarcoma

H. Usami, A. Yamamoto, W. Yamashita, Y. Sugawara, S. Hamada, T. Yamamoto, K. Kato, Susumu Kokeguchi, H. Ohokuni, S. Kotani

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The antitumour effects of lipoteichoic acids (LTA) extracted from Streptococcus pyogenes were studied in comparison with other streptococcal cellular components. LTA suppressed the tumour growth of both solid- and ascites-type Meth A fibrosarcoma as did the whole cells of S. pyogenes (OK-432). No other cellular components, such as cell wall peptidoglycan, group-specific C-carbohydrate or type-specific M protein, suppressed the growth of Meth A. LTA, but not the other cellular components, induced tumour necrosis factor (TNF) in Propionibacterium acnes-primed mice. LTA had no direct killing effects on Meth A cells. These results indicate that LTA may be an important antitumour component of OK-432 and that one of the antitumour mechanisms by this streptococcal preparation is the induction of TNF.

Original languageEnglish
Pages (from-to)70-73
Number of pages4
JournalBritish Journal of Cancer
Volume57
Issue number1
Publication statusPublished - 1988

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Fibrosarcoma
Picibanil
Streptococcus pyogenes
Tumor Necrosis Factor-alpha
Propionibacterium acnes
Peptidoglycan
Growth
Ascites
Cell Wall
Carbohydrates
lipoteichoic acid
Neoplasms
Proteins

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Usami, H., Yamamoto, A., Yamashita, W., Sugawara, Y., Hamada, S., Yamamoto, T., ... Kotani, S. (1988). Antitumour effects of streptococcal lipoteichoic acids on Meth A fibrosarcoma. British Journal of Cancer, 57(1), 70-73.

Antitumour effects of streptococcal lipoteichoic acids on Meth A fibrosarcoma. / Usami, H.; Yamamoto, A.; Yamashita, W.; Sugawara, Y.; Hamada, S.; Yamamoto, T.; Kato, K.; Kokeguchi, Susumu; Ohokuni, H.; Kotani, S.

In: British Journal of Cancer, Vol. 57, No. 1, 1988, p. 70-73.

Research output: Contribution to journalArticle

Usami, H, Yamamoto, A, Yamashita, W, Sugawara, Y, Hamada, S, Yamamoto, T, Kato, K, Kokeguchi, S, Ohokuni, H & Kotani, S 1988, 'Antitumour effects of streptococcal lipoteichoic acids on Meth A fibrosarcoma', British Journal of Cancer, vol. 57, no. 1, pp. 70-73.
Usami H, Yamamoto A, Yamashita W, Sugawara Y, Hamada S, Yamamoto T et al. Antitumour effects of streptococcal lipoteichoic acids on Meth A fibrosarcoma. British Journal of Cancer. 1988;57(1):70-73.
Usami, H. ; Yamamoto, A. ; Yamashita, W. ; Sugawara, Y. ; Hamada, S. ; Yamamoto, T. ; Kato, K. ; Kokeguchi, Susumu ; Ohokuni, H. ; Kotani, S. / Antitumour effects of streptococcal lipoteichoic acids on Meth A fibrosarcoma. In: British Journal of Cancer. 1988 ; Vol. 57, No. 1. pp. 70-73.
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