Antitumour effects of streptococcal lipoteichoic acids on meth a fibrosarcoma

H. Usami, A. Yamamoto, W. Yamashita, Y. Sugawara, S. Hamada, T. Yamamoto, K. Kato, S. Kokeguchi, H. Ohokuni, S. Kotani

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28 Citations (Scopus)

Abstract

The antitumour effects of lipoteichoic acids (LTA) extracted from Streptococcus pyogenes were studied in comparison with other streptococcal cellular components. LTA suppressed the tumour growth of both solid- and ascites-type MethA fibrosarcoma as did the whole cells of S. pyogenes (OK-432). No other cellular components, such as cell wall peptidoglycan, group-specific C-carbohydrate or type-specific M protein, suppressed the growth of MethA. LTA, but not the other cellular components, induced tumour necrosis factor (TNF) in Propionibacterium acnes-primed mice. LTA had no direct killing effects on MethA cells. These results indicate that LTA may be an important antitumour component of OK-432 and that one of the antitumour mechanisms by this streptococcal preparation is the induction of TNF.

Original languageEnglish
Pages (from-to)70-73
Number of pages4
JournalBritish Journal of Cancer
Volume57
Issue number1
DOIs
Publication statusPublished - Jan 1988

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Usami, H., Yamamoto, A., Yamashita, W., Sugawara, Y., Hamada, S., Yamamoto, T., Kato, K., Kokeguchi, S., Ohokuni, H., & Kotani, S. (1988). Antitumour effects of streptococcal lipoteichoic acids on meth a fibrosarcoma. British Journal of Cancer, 57(1), 70-73. https://doi.org/10.1038/bjc.1988.11