Antitumour effects of streptococcal lipoteichoic acids on meth a fibrosarcoma

H. Usami, A. Yamamoto, W. Yamashita, Y. Sugawara, S. Hamada, T. Yamamoto, K. Kato, S. Kokeguchi, H. Ohokuni, S. Kotani

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27 Citations (Scopus)


The antitumour effects of lipoteichoic acids (LTA) extracted from Streptococcus pyogenes were studied in comparison with other streptococcal cellular components. LTA suppressed the tumour growth of both solid- and ascites-type MethA fibrosarcoma as did the whole cells of S. pyogenes (OK-432). No other cellular components, such as cell wall peptidoglycan, group-specific C-carbohydrate or type-specific M protein, suppressed the growth of MethA. LTA, but not the other cellular components, induced tumour necrosis factor (TNF) in Propionibacterium acnes-primed mice. LTA had no direct killing effects on MethA cells. These results indicate that LTA may be an important antitumour component of OK-432 and that one of the antitumour mechanisms by this streptococcal preparation is the induction of TNF.

Original languageEnglish
Pages (from-to)70-73
Number of pages4
JournalBritish Journal of Cancer
Issue number1
Publication statusPublished - Jan 1988

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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