Antitumorigenic and antipromoting activities of ellagic acid, ellagitannins and oligomeric anthocyanin and procyanidin

Andre Castonguay, Hala U. Gali, Elisabeth M. Perchellet, Xiao M. Gao, Mohamed Boukharta, Guylaine Jalbert, Takuo Okuda, Takashi Yoshida, Tsutomu Hatano, Jean Pierre Perchellet

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

We previously showed that ellagic acid (EA) was inhibiting lung tumorigenesis induced by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanone (NNK) in A/J mice. In the present study, we observed that the inhibition of lung tumorigenesis was independent of the solvent used to purified EA. Pomegranate peels extract containing punicalagin (α and β anomers) (10 g/kg diet) and oligomeric anthocyanins (6 g/kg diet) did not inhibit lung tumorigenesis. Raspberry extract (2 x 15 mg) containing sanguiin H6 and lambertianin D as well as oligomeric procyanidins (2 x 15 mg) inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity by about 30%. The same treatments inhibit TPA-stimulated hydroperoxide (HPx) production by about 30 and 70%. Raspberry ellagitannins and oligomeric procyanidins respectively inhibit TPA stimulated DNA synthesis by 42 and 26%. Our results suggest that hydrolyzable and condensed tannins from various sources, which can inhibit the ODC, HPx, and DNA responses to TPA, might also inhibit the tumor-promoting activity of this agent. The results of this study show that EA and ellagitannins have different antitumorigenic and antipromoting activities.

Original languageEnglish
Pages (from-to)367-373
Number of pages7
JournalInternational Journal of Oncology
Volume10
Issue number2
Publication statusPublished - Feb 1997

Fingerprint

Hydrolyzable Tannins
Ellagic Acid
Anthocyanins
Tetradecanoylphorbol Acetate
Proanthocyanidins
Carcinogenesis
Ornithine Decarboxylase
Lung
Punicaceae
Diet
Carcinogens
Hydrogen Peroxide
Tobacco
procyanidin
DNA
Neoplasms
Rubus

Keywords

  • anthocyanin
  • ellagic acid
  • ellagitannins
  • procyanidin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Castonguay, A., Gali, H. U., Perchellet, E. M., Gao, X. M., Boukharta, M., Jalbert, G., ... Perchellet, J. P. (1997). Antitumorigenic and antipromoting activities of ellagic acid, ellagitannins and oligomeric anthocyanin and procyanidin. International Journal of Oncology, 10(2), 367-373.

Antitumorigenic and antipromoting activities of ellagic acid, ellagitannins and oligomeric anthocyanin and procyanidin. / Castonguay, Andre; Gali, Hala U.; Perchellet, Elisabeth M.; Gao, Xiao M.; Boukharta, Mohamed; Jalbert, Guylaine; Okuda, Takuo; Yoshida, Takashi; Hatano, Tsutomu; Perchellet, Jean Pierre.

In: International Journal of Oncology, Vol. 10, No. 2, 02.1997, p. 367-373.

Research output: Contribution to journalArticle

Castonguay, A, Gali, HU, Perchellet, EM, Gao, XM, Boukharta, M, Jalbert, G, Okuda, T, Yoshida, T, Hatano, T & Perchellet, JP 1997, 'Antitumorigenic and antipromoting activities of ellagic acid, ellagitannins and oligomeric anthocyanin and procyanidin', International Journal of Oncology, vol. 10, no. 2, pp. 367-373.
Castonguay A, Gali HU, Perchellet EM, Gao XM, Boukharta M, Jalbert G et al. Antitumorigenic and antipromoting activities of ellagic acid, ellagitannins and oligomeric anthocyanin and procyanidin. International Journal of Oncology. 1997 Feb;10(2):367-373.
Castonguay, Andre ; Gali, Hala U. ; Perchellet, Elisabeth M. ; Gao, Xiao M. ; Boukharta, Mohamed ; Jalbert, Guylaine ; Okuda, Takuo ; Yoshida, Takashi ; Hatano, Tsutomu ; Perchellet, Jean Pierre. / Antitumorigenic and antipromoting activities of ellagic acid, ellagitannins and oligomeric anthocyanin and procyanidin. In: International Journal of Oncology. 1997 ; Vol. 10, No. 2. pp. 367-373.
@article{d6d8f302e030453688a23c9913d5e38b,
title = "Antitumorigenic and antipromoting activities of ellagic acid, ellagitannins and oligomeric anthocyanin and procyanidin",
abstract = "We previously showed that ellagic acid (EA) was inhibiting lung tumorigenesis induced by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanone (NNK) in A/J mice. In the present study, we observed that the inhibition of lung tumorigenesis was independent of the solvent used to purified EA. Pomegranate peels extract containing punicalagin (α and β anomers) (10 g/kg diet) and oligomeric anthocyanins (6 g/kg diet) did not inhibit lung tumorigenesis. Raspberry extract (2 x 15 mg) containing sanguiin H6 and lambertianin D as well as oligomeric procyanidins (2 x 15 mg) inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity by about 30{\%}. The same treatments inhibit TPA-stimulated hydroperoxide (HPx) production by about 30 and 70{\%}. Raspberry ellagitannins and oligomeric procyanidins respectively inhibit TPA stimulated DNA synthesis by 42 and 26{\%}. Our results suggest that hydrolyzable and condensed tannins from various sources, which can inhibit the ODC, HPx, and DNA responses to TPA, might also inhibit the tumor-promoting activity of this agent. The results of this study show that EA and ellagitannins have different antitumorigenic and antipromoting activities.",
keywords = "anthocyanin, ellagic acid, ellagitannins, procyanidin",
author = "Andre Castonguay and Gali, {Hala U.} and Perchellet, {Elisabeth M.} and Gao, {Xiao M.} and Mohamed Boukharta and Guylaine Jalbert and Takuo Okuda and Takashi Yoshida and Tsutomu Hatano and Perchellet, {Jean Pierre}",
year = "1997",
month = "2",
language = "English",
volume = "10",
pages = "367--373",
journal = "International Journal of Oncology",
issn = "1019-6439",
publisher = "Spandidos Publications",
number = "2",

}

TY - JOUR

T1 - Antitumorigenic and antipromoting activities of ellagic acid, ellagitannins and oligomeric anthocyanin and procyanidin

AU - Castonguay, Andre

AU - Gali, Hala U.

AU - Perchellet, Elisabeth M.

AU - Gao, Xiao M.

AU - Boukharta, Mohamed

AU - Jalbert, Guylaine

AU - Okuda, Takuo

AU - Yoshida, Takashi

AU - Hatano, Tsutomu

AU - Perchellet, Jean Pierre

PY - 1997/2

Y1 - 1997/2

N2 - We previously showed that ellagic acid (EA) was inhibiting lung tumorigenesis induced by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanone (NNK) in A/J mice. In the present study, we observed that the inhibition of lung tumorigenesis was independent of the solvent used to purified EA. Pomegranate peels extract containing punicalagin (α and β anomers) (10 g/kg diet) and oligomeric anthocyanins (6 g/kg diet) did not inhibit lung tumorigenesis. Raspberry extract (2 x 15 mg) containing sanguiin H6 and lambertianin D as well as oligomeric procyanidins (2 x 15 mg) inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity by about 30%. The same treatments inhibit TPA-stimulated hydroperoxide (HPx) production by about 30 and 70%. Raspberry ellagitannins and oligomeric procyanidins respectively inhibit TPA stimulated DNA synthesis by 42 and 26%. Our results suggest that hydrolyzable and condensed tannins from various sources, which can inhibit the ODC, HPx, and DNA responses to TPA, might also inhibit the tumor-promoting activity of this agent. The results of this study show that EA and ellagitannins have different antitumorigenic and antipromoting activities.

AB - We previously showed that ellagic acid (EA) was inhibiting lung tumorigenesis induced by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanone (NNK) in A/J mice. In the present study, we observed that the inhibition of lung tumorigenesis was independent of the solvent used to purified EA. Pomegranate peels extract containing punicalagin (α and β anomers) (10 g/kg diet) and oligomeric anthocyanins (6 g/kg diet) did not inhibit lung tumorigenesis. Raspberry extract (2 x 15 mg) containing sanguiin H6 and lambertianin D as well as oligomeric procyanidins (2 x 15 mg) inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity by about 30%. The same treatments inhibit TPA-stimulated hydroperoxide (HPx) production by about 30 and 70%. Raspberry ellagitannins and oligomeric procyanidins respectively inhibit TPA stimulated DNA synthesis by 42 and 26%. Our results suggest that hydrolyzable and condensed tannins from various sources, which can inhibit the ODC, HPx, and DNA responses to TPA, might also inhibit the tumor-promoting activity of this agent. The results of this study show that EA and ellagitannins have different antitumorigenic and antipromoting activities.

KW - anthocyanin

KW - ellagic acid

KW - ellagitannins

KW - procyanidin

UR - http://www.scopus.com/inward/record.url?scp=12644292904&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12644292904&partnerID=8YFLogxK

M3 - Article

VL - 10

SP - 367

EP - 373

JO - International Journal of Oncology

JF - International Journal of Oncology

SN - 1019-6439

IS - 2

ER -