Antitumor effect of interleukin-2 (IL-2) mini-pellet plus LAK cells on Meth-A sarcoma in mice

Toshiyoshi Fujiwara, Ken ichi Sakagami, Junji Matsuoka, Shigehiro Shiozaki, Susumu Uchida, Takenori Kawamura, Shinji Takasu, Futoshi Morisaki, Shinya Saito, Toshihiko Owa, Minoru Haisa, Masaru Inagaki, Kunzo Orita

Research output: Contribution to journalArticle

Abstract

We have evaluated the antitumor effect of IL-2 mini-pellet on the therapy of murine Meth-A sarcoma. After the administration of IL-2 mini-pellet containing 1×106u of IL-2, the serum IL-2 activity was detectable for 72 hours. The s. c. administration of IL-2 mini-pellet and the i. v. injection of LAK cells was effective in inhibiting the tumor growth and could also prolong the survivals. The lytic activites of splenocytes against YAC-1 cells and JTC-11 cells after the administration of IL-2 mini-pellet were augmented. In histological examination on day 7 after the administration of IL-2 mini-pellet, a lot of lymphocytes were invased into tumor tissues. These results suggest that IL-2 mini-pellet can be applied to the adoptive immunotherapy using LAK cells.

Original languageEnglish
Pages (from-to)437-443
Number of pages7
JournalDrug Delivery System
Volume3
Issue number3
DOIs
Publication statusPublished - 1988

Keywords

  • adoptive immunotherapy
  • interleukin-2
  • LAK cells
  • Meth-A sarcoma

ASJC Scopus subject areas

  • Pharmaceutical Science

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    Fujiwara, T., Sakagami, K. I., Matsuoka, J., Shiozaki, S., Uchida, S., Kawamura, T., Takasu, S., Morisaki, F., Saito, S., Owa, T., Haisa, M., Inagaki, M., & Orita, K. (1988). Antitumor effect of interleukin-2 (IL-2) mini-pellet plus LAK cells on Meth-A sarcoma in mice. Drug Delivery System, 3(3), 437-443. https://doi.org/10.2745/dds.3.437