Antitumor activity of oenothein B, a unique macrocyclic ellagitannin

Ken ichi Miyamoto, Masaaki Nomura, Mitsugu Sasakura, Eiichi Matsui, Ryozo Koshiura, Tsugiya Murayama, Toru Furukawa, Tsutomu Hatano, Takashi Yoshida, Takuo Okuda

Research output: Contribution to journalArticle

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Abstract

The antitumor effect of oenothein B, a macrocyclic ellagitannin from Oenothera erythrosepala Bordas, on rodent tumors was studied. Oenothein B exhibited a strong antitumor activity against MM2 ascites tumors upon intraperitoneal administration to the mice before or after the tumor inoculation. The tannin also inhibited the growth of Meth-A solid type tumor in mice. This antitumor effect of the tannin could not be attributed to its direct cytotoxic action on tumor cells, because the cytotoxicity was very weak in the presence of serum protein. When oenothein B was injected into the peritoneal cavity of mice, peritoneal exudate cells, including cytostatic macrophages, were induced. Further-more, in the in vitro treatment of macrophages from mice and humans, the tannin stimulated release of an interleukin 1 (IL-1)-like activity and IL-1β from the cells. These results suggest that oenothein B exerts its antitumor effect through potentiation of the host-immune defense via activation of macrophages.

Original languageEnglish
Pages (from-to)99-103
Number of pages5
JournalJapanese Journal of Cancer Research
Volume84
Issue number1
Publication statusPublished - Jan 1993

Fingerprint

Tannins
Neoplasms
Interleukin-1
Oenothera
Macrophages
Macrophage Activation
Peritoneal Cavity
Cytostatic Agents
Exudates and Transudates
Ascites
Blood Proteins
Rodentia
oenothein B
ellagitannin
Growth

Keywords

  • Antitumor effect
  • Interleukin 1
  • Macrophage
  • Oenothein B
  • Tannin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Miyamoto, K. I., Nomura, M., Sasakura, M., Matsui, E., Koshiura, R., Murayama, T., ... Okuda, T. (1993). Antitumor activity of oenothein B, a unique macrocyclic ellagitannin. Japanese Journal of Cancer Research, 84(1), 99-103.

Antitumor activity of oenothein B, a unique macrocyclic ellagitannin. / Miyamoto, Ken ichi; Nomura, Masaaki; Sasakura, Mitsugu; Matsui, Eiichi; Koshiura, Ryozo; Murayama, Tsugiya; Furukawa, Toru; Hatano, Tsutomu; Yoshida, Takashi; Okuda, Takuo.

In: Japanese Journal of Cancer Research, Vol. 84, No. 1, 01.1993, p. 99-103.

Research output: Contribution to journalArticle

Miyamoto, KI, Nomura, M, Sasakura, M, Matsui, E, Koshiura, R, Murayama, T, Furukawa, T, Hatano, T, Yoshida, T & Okuda, T 1993, 'Antitumor activity of oenothein B, a unique macrocyclic ellagitannin', Japanese Journal of Cancer Research, vol. 84, no. 1, pp. 99-103.
Miyamoto KI, Nomura M, Sasakura M, Matsui E, Koshiura R, Murayama T et al. Antitumor activity of oenothein B, a unique macrocyclic ellagitannin. Japanese Journal of Cancer Research. 1993 Jan;84(1):99-103.
Miyamoto, Ken ichi ; Nomura, Masaaki ; Sasakura, Mitsugu ; Matsui, Eiichi ; Koshiura, Ryozo ; Murayama, Tsugiya ; Furukawa, Toru ; Hatano, Tsutomu ; Yoshida, Takashi ; Okuda, Takuo. / Antitumor activity of oenothein B, a unique macrocyclic ellagitannin. In: Japanese Journal of Cancer Research. 1993 ; Vol. 84, No. 1. pp. 99-103.
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