Antitumor activity of compounds isolated from leaves of Eriobotrya japonica

Hideyuki Ito, Eri Kobayashi, Shu Hua Li, Tsutomu Hatano, Daigo Sugita, Naoki Kubo, Susumu Shimura, Yoshio Itoh, Harukuni Tokuda, Hoyoku Nishino, Takashi Yoshida

Research output: Contribution to journalArticlepeer-review

79 Citations (Scopus)


In a search for possible antitumor agents from natural sources, megastigmane glycosides and polyphenolic constituents isolated from the leaves of Eriobotrya japonica (Rosaceae) were found to inhibit the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced activation of Epstein-Barr virus early antigen in Raji cells. Roseoside and procyanidin B-2 were among the active compounds found in an in vitro assay; these compounds were further assessed for antitumor activity in vivo in a two-stage carcinogenesis assay on mouse skin. Roseoside significantly delayed carcinogenesis induced by peroxynitrite (initiator) and TPA (promoter), and its potency was comparable to that of a green tea polyphenol, (-)-epigallocatechin 3-O-gallate, in the same assay.

Original languageEnglish
Pages (from-to)2400-2403
Number of pages4
JournalJournal of agricultural and food chemistry
Issue number8
Publication statusPublished - Apr 10 2002


  • (-)-epigallocatechin 3-O-gallate
  • Antitumor activity
  • Epstein-Barr virus activation
  • Eriobotrya japonica
  • Megastigmane glycosides
  • Two-stage carcinogenesis

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)


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