Antitumor activity of compounds isolated from leaves of Eriobotrya japonica

Hideyuki Ito, Eri Kobayashi, Shu Hua Li, Tsutomu Hatano, Daigo Sugita, Naoki Kubo, Susumu Shimura, Yoshio Itoh, Harukuni Tokuda, Hoyoku Nishino, Takashi Yoshida

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

In a search for possible antitumor agents from natural sources, megastigmane glycosides and polyphenolic constituents isolated from the leaves of Eriobotrya japonica (Rosaceae) were found to inhibit the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced activation of Epstein-Barr virus early antigen in Raji cells. Roseoside and procyanidin B-2 were among the active compounds found in an in vitro assay; these compounds were further assessed for antitumor activity in vivo in a two-stage carcinogenesis assay on mouse skin. Roseoside significantly delayed carcinogenesis induced by peroxynitrite (initiator) and TPA (promoter), and its potency was comparable to that of a green tea polyphenol, (-)-epigallocatechin 3-O-gallate, in the same assay.

Original languageEnglish
Pages (from-to)2400-2403
Number of pages4
JournalJournal of Agricultural and Food Chemistry
Volume50
Issue number8
DOIs
Publication statusPublished - Apr 10 2002

Fingerprint

Eriobotrya
Eriobotrya japonica
Tetradecanoylphorbol Acetate
Assays
Carcinogenesis
Rosaceae
carcinogenesis
Peroxynitrous Acid
polyphenols
Acetates
Polyphenols
assays
Tea
Glycosides
acetates
Antineoplastic Agents
leaves
norisoprenoids
Human herpesvirus 4
antineoplastic agents

Keywords

  • (-)-epigallocatechin 3-O-gallate
  • Antitumor activity
  • Epstein-Barr virus activation
  • Eriobotrya japonica
  • Megastigmane glycosides
  • Two-stage carcinogenesis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Food Science
  • Chemistry (miscellaneous)

Cite this

Antitumor activity of compounds isolated from leaves of Eriobotrya japonica. / Ito, Hideyuki; Kobayashi, Eri; Li, Shu Hua; Hatano, Tsutomu; Sugita, Daigo; Kubo, Naoki; Shimura, Susumu; Itoh, Yoshio; Tokuda, Harukuni; Nishino, Hoyoku; Yoshida, Takashi.

In: Journal of Agricultural and Food Chemistry, Vol. 50, No. 8, 10.04.2002, p. 2400-2403.

Research output: Contribution to journalArticle

Ito, H, Kobayashi, E, Li, SH, Hatano, T, Sugita, D, Kubo, N, Shimura, S, Itoh, Y, Tokuda, H, Nishino, H & Yoshida, T 2002, 'Antitumor activity of compounds isolated from leaves of Eriobotrya japonica', Journal of Agricultural and Food Chemistry, vol. 50, no. 8, pp. 2400-2403. https://doi.org/10.1021/jf011083l
Ito, Hideyuki ; Kobayashi, Eri ; Li, Shu Hua ; Hatano, Tsutomu ; Sugita, Daigo ; Kubo, Naoki ; Shimura, Susumu ; Itoh, Yoshio ; Tokuda, Harukuni ; Nishino, Hoyoku ; Yoshida, Takashi. / Antitumor activity of compounds isolated from leaves of Eriobotrya japonica. In: Journal of Agricultural and Food Chemistry. 2002 ; Vol. 50, No. 8. pp. 2400-2403.
@article{70715f970344462dbb6a9c3d3b2a868e,
title = "Antitumor activity of compounds isolated from leaves of Eriobotrya japonica",
abstract = "In a search for possible antitumor agents from natural sources, megastigmane glycosides and polyphenolic constituents isolated from the leaves of Eriobotrya japonica (Rosaceae) were found to inhibit the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced activation of Epstein-Barr virus early antigen in Raji cells. Roseoside and procyanidin B-2 were among the active compounds found in an in vitro assay; these compounds were further assessed for antitumor activity in vivo in a two-stage carcinogenesis assay on mouse skin. Roseoside significantly delayed carcinogenesis induced by peroxynitrite (initiator) and TPA (promoter), and its potency was comparable to that of a green tea polyphenol, (-)-epigallocatechin 3-O-gallate, in the same assay.",
keywords = "(-)-epigallocatechin 3-O-gallate, Antitumor activity, Epstein-Barr virus activation, Eriobotrya japonica, Megastigmane glycosides, Two-stage carcinogenesis",
author = "Hideyuki Ito and Eri Kobayashi and Li, {Shu Hua} and Tsutomu Hatano and Daigo Sugita and Naoki Kubo and Susumu Shimura and Yoshio Itoh and Harukuni Tokuda and Hoyoku Nishino and Takashi Yoshida",
year = "2002",
month = "4",
day = "10",
doi = "10.1021/jf011083l",
language = "English",
volume = "50",
pages = "2400--2403",
journal = "Journal of Agricultural and Food Chemistry",
issn = "0021-8561",
publisher = "American Chemical Society",
number = "8",

}

TY - JOUR

T1 - Antitumor activity of compounds isolated from leaves of Eriobotrya japonica

AU - Ito, Hideyuki

AU - Kobayashi, Eri

AU - Li, Shu Hua

AU - Hatano, Tsutomu

AU - Sugita, Daigo

AU - Kubo, Naoki

AU - Shimura, Susumu

AU - Itoh, Yoshio

AU - Tokuda, Harukuni

AU - Nishino, Hoyoku

AU - Yoshida, Takashi

PY - 2002/4/10

Y1 - 2002/4/10

N2 - In a search for possible antitumor agents from natural sources, megastigmane glycosides and polyphenolic constituents isolated from the leaves of Eriobotrya japonica (Rosaceae) were found to inhibit the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced activation of Epstein-Barr virus early antigen in Raji cells. Roseoside and procyanidin B-2 were among the active compounds found in an in vitro assay; these compounds were further assessed for antitumor activity in vivo in a two-stage carcinogenesis assay on mouse skin. Roseoside significantly delayed carcinogenesis induced by peroxynitrite (initiator) and TPA (promoter), and its potency was comparable to that of a green tea polyphenol, (-)-epigallocatechin 3-O-gallate, in the same assay.

AB - In a search for possible antitumor agents from natural sources, megastigmane glycosides and polyphenolic constituents isolated from the leaves of Eriobotrya japonica (Rosaceae) were found to inhibit the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced activation of Epstein-Barr virus early antigen in Raji cells. Roseoside and procyanidin B-2 were among the active compounds found in an in vitro assay; these compounds were further assessed for antitumor activity in vivo in a two-stage carcinogenesis assay on mouse skin. Roseoside significantly delayed carcinogenesis induced by peroxynitrite (initiator) and TPA (promoter), and its potency was comparable to that of a green tea polyphenol, (-)-epigallocatechin 3-O-gallate, in the same assay.

KW - (-)-epigallocatechin 3-O-gallate

KW - Antitumor activity

KW - Epstein-Barr virus activation

KW - Eriobotrya japonica

KW - Megastigmane glycosides

KW - Two-stage carcinogenesis

UR - http://www.scopus.com/inward/record.url?scp=0037051517&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037051517&partnerID=8YFLogxK

U2 - 10.1021/jf011083l

DO - 10.1021/jf011083l

M3 - Article

C2 - 11929303

AN - SCOPUS:0037051517

VL - 50

SP - 2400

EP - 2403

JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

SN - 0021-8561

IS - 8

ER -