Antitumor activity of compounds isolated from leaves of Eriobotrya japonica

Hideyuki Ito; Eri Kobayashi; Shu Hua Li; Tsutomu Hatano; Daigo Sugita; Naoki Kubo; Susumu Shimura; Yoshio Itoh; Harukuni Tokuda; Hoyoku Nishino; Takashi Yoshida

doi:10.1021/jf011083l

Antitumor activity of compounds isolated from leaves of Eriobotrya japonica

Hideyuki Ito, Eri Kobayashi, Shu Hua Li, Tsutomu Hatano, Daigo Sugita, Naoki Kubo, Susumu Shimura, Yoshio Itoh, Harukuni Tokuda, Hoyoku Nishino, Takashi Yoshida

Research output: Contribution to journal › Article › peer-review

79 Citations (Scopus)

Abstract

In a search for possible antitumor agents from natural sources, megastigmane glycosides and polyphenolic constituents isolated from the leaves of Eriobotrya japonica (Rosaceae) were found to inhibit the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced activation of Epstein-Barr virus early antigen in Raji cells. Roseoside and procyanidin B-2 were among the active compounds found in an in vitro assay; these compounds were further assessed for antitumor activity in vivo in a two-stage carcinogenesis assay on mouse skin. Roseoside significantly delayed carcinogenesis induced by peroxynitrite (initiator) and TPA (promoter), and its potency was comparable to that of a green tea polyphenol, (-)-epigallocatechin 3-O-gallate, in the same assay.

Original language	English
Pages (from-to)	2400-2403
Number of pages	4
Journal	Journal of agricultural and food chemistry
Volume	50
Issue number	8
DOIs	https://doi.org/10.1021/jf011083l
Publication status	Published - Apr 10 2002

Keywords

(-)-epigallocatechin 3-O-gallate
Antitumor activity
Epstein-Barr virus activation
Eriobotrya japonica
Megastigmane glycosides
Two-stage carcinogenesis

ASJC Scopus subject areas

Chemistry(all)
Agricultural and Biological Sciences(all)

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10.1021/jf011083l

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title = "Antitumor activity of compounds isolated from leaves of Eriobotrya japonica",

abstract = "In a search for possible antitumor agents from natural sources, megastigmane glycosides and polyphenolic constituents isolated from the leaves of Eriobotrya japonica (Rosaceae) were found to inhibit the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced activation of Epstein-Barr virus early antigen in Raji cells. Roseoside and procyanidin B-2 were among the active compounds found in an in vitro assay; these compounds were further assessed for antitumor activity in vivo in a two-stage carcinogenesis assay on mouse skin. Roseoside significantly delayed carcinogenesis induced by peroxynitrite (initiator) and TPA (promoter), and its potency was comparable to that of a green tea polyphenol, (-)-epigallocatechin 3-O-gallate, in the same assay.",

keywords = "(-)-epigallocatechin 3-O-gallate, Antitumor activity, Epstein-Barr virus activation, Eriobotrya japonica, Megastigmane glycosides, Two-stage carcinogenesis",

author = "Hideyuki Ito and Eri Kobayashi and Li, {Shu Hua} and Tsutomu Hatano and Daigo Sugita and Naoki Kubo and Susumu Shimura and Yoshio Itoh and Harukuni Tokuda and Hoyoku Nishino and Takashi Yoshida",

year = "2002",

month = apr,

day = "10",

doi = "10.1021/jf011083l",

language = "English",

volume = "50",

pages = "2400--2403",

journal = "Journal of Agricultural and Food Chemistry",

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T1 - Antitumor activity of compounds isolated from leaves of Eriobotrya japonica

AU - Ito, Hideyuki

AU - Kobayashi, Eri

AU - Li, Shu Hua

AU - Hatano, Tsutomu

AU - Sugita, Daigo

AU - Kubo, Naoki

AU - Shimura, Susumu

AU - Itoh, Yoshio

AU - Tokuda, Harukuni

AU - Nishino, Hoyoku

AU - Yoshida, Takashi

PY - 2002/4/10

Y1 - 2002/4/10

N2 - In a search for possible antitumor agents from natural sources, megastigmane glycosides and polyphenolic constituents isolated from the leaves of Eriobotrya japonica (Rosaceae) were found to inhibit the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced activation of Epstein-Barr virus early antigen in Raji cells. Roseoside and procyanidin B-2 were among the active compounds found in an in vitro assay; these compounds were further assessed for antitumor activity in vivo in a two-stage carcinogenesis assay on mouse skin. Roseoside significantly delayed carcinogenesis induced by peroxynitrite (initiator) and TPA (promoter), and its potency was comparable to that of a green tea polyphenol, (-)-epigallocatechin 3-O-gallate, in the same assay.

AB - In a search for possible antitumor agents from natural sources, megastigmane glycosides and polyphenolic constituents isolated from the leaves of Eriobotrya japonica (Rosaceae) were found to inhibit the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced activation of Epstein-Barr virus early antigen in Raji cells. Roseoside and procyanidin B-2 were among the active compounds found in an in vitro assay; these compounds were further assessed for antitumor activity in vivo in a two-stage carcinogenesis assay on mouse skin. Roseoside significantly delayed carcinogenesis induced by peroxynitrite (initiator) and TPA (promoter), and its potency was comparable to that of a green tea polyphenol, (-)-epigallocatechin 3-O-gallate, in the same assay.

KW - (-)-epigallocatechin 3-O-gallate

KW - Antitumor activity

KW - Epstein-Barr virus activation

KW - Eriobotrya japonica

KW - Megastigmane glycosides

KW - Two-stage carcinogenesis

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U2 - 10.1021/jf011083l

DO - 10.1021/jf011083l

M3 - Article

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AN - SCOPUS:0037051517

SN - 0021-8561

VL - 50

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JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

IS - 8

ER -

Antitumor activity of compounds isolated from leaves of Eriobotrya japonica

Abstract

Keywords

ASJC Scopus subject areas

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