Antitumor activity and interleukin-1 induction by tannins

K. I. Miyamoto, T. Murayama, M. Nomura, Tsutomu Hatano, T. Yoshida, T. Furukawa, R. Koshiura, T. Okuda

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The reletionships between structures, antitumor activities and interleukin-1 (IL-1) induction by fifteen tannins were studies. When tannins (10 mg/kg) were intraperitoneally injected into mice once, 4 days before intraperitoneal inoculation of S-180 cells, tellimagrandin II, rugosin A, hirtellin B, oenothein B and oenothein A, which have only tellimagrandins I or II units in their molecules, had significant antitumor activity. Although casuarictin and its related tannins were ineffective, agrimonin, which is a dimer, had a strong effect, as previously reported. On the other hand, monomeric ellagitannins such as tellimagrandins I and II, rugosin A and casuarictin also increased IL-1β production from human peripheral macrophages in vitro by 2-fold over the non-stimulated basal production and oligomeric ellagitannins with strong antitumor activity more potently stimulated the IL-1β induction. Other tannins having no antitumor activity induced less IL-1β. This study indicates that oligomeric ellagitannins, which consist of tellimagrandin I or II, casuarictin or their related structure units, have antitumor activity and induce IL-1β.

Original languageEnglish
Pages (from-to)37-42
Number of pages6
JournalAnticancer Research
Volume13
Issue number1
Publication statusPublished - 1993
Externally publishedYes

Fingerprint

Tannins
Interleukin-1
Hydrolyzable Tannins
Macrophages
casuarictin
rugosin A
tellimagrandin II

Keywords

  • Antitumor activity
  • IL-1 production
  • Structure
  • Tannin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Miyamoto, K. I., Murayama, T., Nomura, M., Hatano, T., Yoshida, T., Furukawa, T., ... Okuda, T. (1993). Antitumor activity and interleukin-1 induction by tannins. Anticancer Research, 13(1), 37-42.

Antitumor activity and interleukin-1 induction by tannins. / Miyamoto, K. I.; Murayama, T.; Nomura, M.; Hatano, Tsutomu; Yoshida, T.; Furukawa, T.; Koshiura, R.; Okuda, T.

In: Anticancer Research, Vol. 13, No. 1, 1993, p. 37-42.

Research output: Contribution to journalArticle

Miyamoto, KI, Murayama, T, Nomura, M, Hatano, T, Yoshida, T, Furukawa, T, Koshiura, R & Okuda, T 1993, 'Antitumor activity and interleukin-1 induction by tannins', Anticancer Research, vol. 13, no. 1, pp. 37-42.
Miyamoto KI, Murayama T, Nomura M, Hatano T, Yoshida T, Furukawa T et al. Antitumor activity and interleukin-1 induction by tannins. Anticancer Research. 1993;13(1):37-42.
Miyamoto, K. I. ; Murayama, T. ; Nomura, M. ; Hatano, Tsutomu ; Yoshida, T. ; Furukawa, T. ; Koshiura, R. ; Okuda, T. / Antitumor activity and interleukin-1 induction by tannins. In: Anticancer Research. 1993 ; Vol. 13, No. 1. pp. 37-42.
@article{c0c380a100a140e5b717a4a3552c1a86,
title = "Antitumor activity and interleukin-1 induction by tannins",
abstract = "The reletionships between structures, antitumor activities and interleukin-1 (IL-1) induction by fifteen tannins were studies. When tannins (10 mg/kg) were intraperitoneally injected into mice once, 4 days before intraperitoneal inoculation of S-180 cells, tellimagrandin II, rugosin A, hirtellin B, oenothein B and oenothein A, which have only tellimagrandins I or II units in their molecules, had significant antitumor activity. Although casuarictin and its related tannins were ineffective, agrimonin, which is a dimer, had a strong effect, as previously reported. On the other hand, monomeric ellagitannins such as tellimagrandins I and II, rugosin A and casuarictin also increased IL-1β production from human peripheral macrophages in vitro by 2-fold over the non-stimulated basal production and oligomeric ellagitannins with strong antitumor activity more potently stimulated the IL-1β induction. Other tannins having no antitumor activity induced less IL-1β. This study indicates that oligomeric ellagitannins, which consist of tellimagrandin I or II, casuarictin or their related structure units, have antitumor activity and induce IL-1β.",
keywords = "Antitumor activity, IL-1 production, Structure, Tannin",
author = "Miyamoto, {K. I.} and T. Murayama and M. Nomura and Tsutomu Hatano and T. Yoshida and T. Furukawa and R. Koshiura and T. Okuda",
year = "1993",
language = "English",
volume = "13",
pages = "37--42",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "1",

}

TY - JOUR

T1 - Antitumor activity and interleukin-1 induction by tannins

AU - Miyamoto, K. I.

AU - Murayama, T.

AU - Nomura, M.

AU - Hatano, Tsutomu

AU - Yoshida, T.

AU - Furukawa, T.

AU - Koshiura, R.

AU - Okuda, T.

PY - 1993

Y1 - 1993

N2 - The reletionships between structures, antitumor activities and interleukin-1 (IL-1) induction by fifteen tannins were studies. When tannins (10 mg/kg) were intraperitoneally injected into mice once, 4 days before intraperitoneal inoculation of S-180 cells, tellimagrandin II, rugosin A, hirtellin B, oenothein B and oenothein A, which have only tellimagrandins I or II units in their molecules, had significant antitumor activity. Although casuarictin and its related tannins were ineffective, agrimonin, which is a dimer, had a strong effect, as previously reported. On the other hand, monomeric ellagitannins such as tellimagrandins I and II, rugosin A and casuarictin also increased IL-1β production from human peripheral macrophages in vitro by 2-fold over the non-stimulated basal production and oligomeric ellagitannins with strong antitumor activity more potently stimulated the IL-1β induction. Other tannins having no antitumor activity induced less IL-1β. This study indicates that oligomeric ellagitannins, which consist of tellimagrandin I or II, casuarictin or their related structure units, have antitumor activity and induce IL-1β.

AB - The reletionships between structures, antitumor activities and interleukin-1 (IL-1) induction by fifteen tannins were studies. When tannins (10 mg/kg) were intraperitoneally injected into mice once, 4 days before intraperitoneal inoculation of S-180 cells, tellimagrandin II, rugosin A, hirtellin B, oenothein B and oenothein A, which have only tellimagrandins I or II units in their molecules, had significant antitumor activity. Although casuarictin and its related tannins were ineffective, agrimonin, which is a dimer, had a strong effect, as previously reported. On the other hand, monomeric ellagitannins such as tellimagrandins I and II, rugosin A and casuarictin also increased IL-1β production from human peripheral macrophages in vitro by 2-fold over the non-stimulated basal production and oligomeric ellagitannins with strong antitumor activity more potently stimulated the IL-1β induction. Other tannins having no antitumor activity induced less IL-1β. This study indicates that oligomeric ellagitannins, which consist of tellimagrandin I or II, casuarictin or their related structure units, have antitumor activity and induce IL-1β.

KW - Antitumor activity

KW - IL-1 production

KW - Structure

KW - Tannin

UR - http://www.scopus.com/inward/record.url?scp=0027457586&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027457586&partnerID=8YFLogxK

M3 - Article

C2 - 8476228

AN - SCOPUS:0027457586

VL - 13

SP - 37

EP - 42

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 1

ER -