Antitumor activities of ellagitannins against sarcoma-180 in mice

K. Miyamoto, M. Nomura, T. Murayama, T. Furukawa, T. Hatano, Tsutomu Hatano, R. Koshiura, T. Okuda

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Abstract

Forty-five ellagitannins and related compounds were intraperitoneally injected into mice once, 4 d before intraperitoneal inoculation of S-180 cells, and their antitumor activities were evaluated. When an antitumor-active tannin was defined as one producing a 70% increase or more in the mean life span of mice or one regressor out of six mice, twenty-one ellagitannins were active. Among monomeric ellagitannins, tellimagrandin II was most active. Most of the oligomeric ellagitannins, consisting of tellimagrandins I and II as the monomer unit, had a significant antitumor activity. Macrocyclic ellagitannins were all active. Oenothein B, among them, had the most potent antitumor activity. In contrast, ellagitannins containing a casuarictin or potentillin moiety in their molecules, except for extensively oligomerized ones, showed very low or negligible activity. These results suggest that tannins need the ellagitannin monomer units, having galloyl groups at the O-2 and O-3 positions on the glucose core(s), such as tellimagrandins, in order to exhibit a strong antitumor activity.

Original languageEnglish
Pages (from-to)379-387
Number of pages9
JournalBiological and Pharmaceutical Bulletin
Volume16
Issue number4
Publication statusPublished - 1993

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Hydrolyzable Tannins
Sarcoma 180
Tannins
Glucose

Keywords

  • antitumor activity
  • ellagitannin
  • S-180
  • structure-activity relationship
  • tannin

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Miyamoto, K., Nomura, M., Murayama, T., Furukawa, T., Hatano, T., Hatano, T., ... Okuda, T. (1993). Antitumor activities of ellagitannins against sarcoma-180 in mice. Biological and Pharmaceutical Bulletin, 16(4), 379-387.

Antitumor activities of ellagitannins against sarcoma-180 in mice. / Miyamoto, K.; Nomura, M.; Murayama, T.; Furukawa, T.; Hatano, T.; Hatano, Tsutomu; Koshiura, R.; Okuda, T.

In: Biological and Pharmaceutical Bulletin, Vol. 16, No. 4, 1993, p. 379-387.

Research output: Contribution to journalArticle

Miyamoto, K, Nomura, M, Murayama, T, Furukawa, T, Hatano, T, Hatano, T, Koshiura, R & Okuda, T 1993, 'Antitumor activities of ellagitannins against sarcoma-180 in mice', Biological and Pharmaceutical Bulletin, vol. 16, no. 4, pp. 379-387.
Miyamoto K, Nomura M, Murayama T, Furukawa T, Hatano T, Hatano T et al. Antitumor activities of ellagitannins against sarcoma-180 in mice. Biological and Pharmaceutical Bulletin. 1993;16(4):379-387.
Miyamoto, K. ; Nomura, M. ; Murayama, T. ; Furukawa, T. ; Hatano, T. ; Hatano, Tsutomu ; Koshiura, R. ; Okuda, T. / Antitumor activities of ellagitannins against sarcoma-180 in mice. In: Biological and Pharmaceutical Bulletin. 1993 ; Vol. 16, No. 4. pp. 379-387.
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