Abstract
Antisense technology was developed to inhibit gene expression by utilizing an oligonucleotide complementary to the mRNA which encodes the target gene. There are a few possible mechanisms for the inhibitory effects of antisense oligonucleotides. Among them, degradation of mRNA by RNase H is considered to be the major mechanism of action for antisense oligonucleotides. This technique was originally used to elucidate the function of a target gene, but may also have therapeutic applications, provided it is designed carefully and properly.
| Original language | English |
|---|---|
| Pages (from-to) | 84-88 |
| Number of pages | 5 |
| Journal | Experimental Nephrology |
| Volume | 6 |
| Issue number | 1 |
| Publication status | Published - Mar 13 1998 |
Keywords
- Antisense oligonucleotides
- Gene therapy
- Liposomes
ASJC Scopus subject areas
- Nephrology
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Cite this
Kashihara, N., Maeshima, Y., & Makino, H. (1998). Antisense oligonucleotides. Experimental Nephrology, 6(1), 84-88.