Antiproliferative activity of REIC/Dkk-3 and its significant down-regulation in non-small-cell lung carcinomas

Toshiya Tsuji, Isao Nozaki, Masahiro Miyazaki, Masakiyo Sakaguchi, Hong Pu, Yusuke Hamazaki, Osamu Iijima, Masayoshi Namba

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

We recently reported the cloning of the REIC/Dkk-3 gene, whose expression was shown to be down-regulated in many human immortalized and tumor-derived cell lines [T. Tsuji et al. (2000) Biochem. Biophys. Res. Commun. 268, 20-24]. In the present study, we demonstrated that expression of the exogenous REIC/Dkk-3 gene in tumor cells inhibited cell growth. Furthermore, the level of REIC/Dkk-3 mRNA in normal human cells was lowest in the late G1 phase during the cell cycle. Then we found that the expression of REIC/Dkk-3 was significantly down-regulated in surgically resected non-small-cell lung carcinomas. We determined the REIC/Dkk-3 locus on chromosome 11p15, where loss of heterozygosity has frequently been observed in human tumors. These findings indicate that REIC/Dkk-3 may function as a tumor suppressor.

Original languageEnglish
Pages (from-to)257-263
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume289
Issue number1
DOIs
Publication statusPublished - Nov 23 2001

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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