Antinematodal activities of ingenane diterpenes from Euphorbia kansui and their derivatives against the pine wood nematode (Bursaphelenchus xylophilus)

Jianxiao Shi, Zhixuan Li, Teruhiko Nitoda, Minoru Izumi, Hiroshi Kanzaki, Naomichi Baba, Kazuyoshi Kawazu, Shuhei Nakajima

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Under the bioassay-guided method, two diterpenes, 3-O-(2″,3″- dimethylbutanoyl)-13-O-dodecanoylingenol (1) and 3-O-(2″,3″- dimethylbutanoyl)-13-O-decanoylingenol (2) isolated from Euphorbia kansui, showed a pronounced antinematodal activity against the nematode Bursaphelenchus xylophilus at the same minimum effective dose (MED) of 5 μg per cotton ball and still displayed antinematodal activity at a dose of 2.5 μg per cotton ball. Compounds 3-6 were obtained, and the structure of the new compound 6 was elucidated based on 1D-and 2D-NMR analyses and physicochemical data. Preliminary structure-biological activity relationships of ingenane-type compounds were deduced.

Original languageEnglish
Pages (from-to)59-65
Number of pages7
JournalZeitschrift fur Naturforschung - Section C Journal of Biosciences
Volume63
Issue number1-2
DOIs
Publication statusPublished - Jan 1 2008

Keywords

  • Antinematodal
  • Bursaphelenchus xylophilus
  • Euphorbia kansui
  • Ingenane diterpenes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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