Abstract
Under the bioassay-guided method, two diterpenes, 3-O-(2″,3″- dimethylbutanoyl)-13-O-dodecanoylingenol (1) and 3-O-(2″,3″- dimethylbutanoyl)-13-O-decanoylingenol (2) isolated from Euphorbia kansui, showed a pronounced antinematodal activity against the nematode Bursaphelenchus xylophilus at the same minimum effective dose (MED) of 5 μg per cotton ball and still displayed antinematodal activity at a dose of 2.5 μg per cotton ball. Compounds 3-6 were obtained, and the structure of the new compound 6 was elucidated based on 1D-and 2D-NMR analyses and physicochemical data. Preliminary structure-biological activity relationships of ingenane-type compounds were deduced.
| Original language | English |
|---|---|
| Pages (from-to) | 59-65 |
| Number of pages | 7 |
| Journal | Zeitschrift fur Naturforschung - Section C Journal of Biosciences |
| Volume | 63 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Jan 1 2008 |
Keywords
- Antinematodal
- Bursaphelenchus xylophilus
- Euphorbia kansui
- Ingenane diterpenes
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Cite this
Shi, J., Li, Z., Nitoda, T., Izumi, M., Kanzaki, H., Baba, N., Kawazu, K., & Nakajima, S. (2008). Antinematodal activities of ingenane diterpenes from Euphorbia kansui and their derivatives against the pine wood nematode (Bursaphelenchus xylophilus). Zeitschrift fur Naturforschung - Section C Journal of Biosciences, 63(1-2), 59-65. https://doi.org/10.1515/znc-2008-1-211