Antinematodal activities of ingenane diterpenes from Euphorbia kansui and their derivatives against the pine wood nematode (Bursaphelenchus xylophilus)

Jianxiao Shi; Zhixuan Li; Teruhiko Nitoda; Minoru Izumi; Hiroshi Kanzaki; Naomichi Baba; Kazuyoshi Kawazu; Shuhei Nakajima

doi:10.1515/znc-2008-1-211

Antinematodal activities of ingenane diterpenes from Euphorbia kansui and their derivatives against the pine wood nematode (Bursaphelenchus xylophilus)

Jianxiao Shi, Zhixuan Li, Teruhiko Nitoda, Minoru Izumi, Hiroshi Kanzaki, Naomichi Baba, Kazuyoshi Kawazu, Shuhei Nakajima

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Under the bioassay-guided method, two diterpenes, 3-O-(2″,3″- dimethylbutanoyl)-13-O-dodecanoylingenol (1) and 3-O-(2″,3″- dimethylbutanoyl)-13-O-decanoylingenol (2) isolated from Euphorbia kansui, showed a pronounced antinematodal activity against the nematode Bursaphelenchus xylophilus at the same minimum effective dose (MED) of 5 μg per cotton ball and still displayed antinematodal activity at a dose of 2.5 μg per cotton ball. Compounds 3-6 were obtained, and the structure of the new compound 6 was elucidated based on 1D-and 2D-NMR analyses and physicochemical data. Preliminary structure-biological activity relationships of ingenane-type compounds were deduced.

Original language	English
Pages (from-to)	59-65
Number of pages	7
Journal	Zeitschrift fur Naturforschung - Section C Journal of Biosciences
Volume	63
Issue number	1-2
DOIs	https://doi.org/10.1515/znc-2008-1-211
Publication status	Published - 2008

Keywords

Antinematodal
Bursaphelenchus xylophilus
Euphorbia kansui
Ingenane diterpenes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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Shi, J., Li, Z., Nitoda, T., Izumi, M., Kanzaki, H., Baba, N., Kawazu, K., & Nakajima, S. (2008). Antinematodal activities of ingenane diterpenes from Euphorbia kansui and their derivatives against the pine wood nematode (Bursaphelenchus xylophilus). Zeitschrift fur Naturforschung - Section C Journal of Biosciences, 63(1-2), 59-65. https://doi.org/10.1515/znc-2008-1-211

Antinematodal activities of ingenane diterpenes from Euphorbia kansui and their derivatives against the pine wood nematode (Bursaphelenchus xylophilus). / Shi, Jianxiao; Li, Zhixuan; Nitoda, Teruhiko ; Izumi, Minoru ; Kanzaki, Hiroshi; Baba, Naomichi; Kawazu, Kazuyoshi; Nakajima, Shuhei.

In: Zeitschrift fur Naturforschung - Section C Journal of Biosciences, Vol. 63, No. 1-2, 2008, p. 59-65.

Research output: Contribution to journal › Article › peer-review

Shi, J, Li, Z, Nitoda, T , Izumi, M , Kanzaki, H, Baba, N, Kawazu, K & Nakajima, S 2008, 'Antinematodal activities of ingenane diterpenes from Euphorbia kansui and their derivatives against the pine wood nematode (Bursaphelenchus xylophilus)', Zeitschrift fur Naturforschung - Section C Journal of Biosciences, vol. 63, no. 1-2, pp. 59-65. https://doi.org/10.1515/znc-2008-1-211

Shi, Jianxiao ; Li, Zhixuan ; Nitoda, Teruhiko ; Izumi, Minoru ; Kanzaki, Hiroshi ; Baba, Naomichi ; Kawazu, Kazuyoshi ; Nakajima, Shuhei. / Antinematodal activities of ingenane diterpenes from Euphorbia kansui and their derivatives against the pine wood nematode (Bursaphelenchus xylophilus). In: Zeitschrift fur Naturforschung - Section C Journal of Biosciences. 2008 ; Vol. 63, No. 1-2. pp. 59-65.

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abstract = "Under the bioassay-guided method, two diterpenes, 3-O-(2″,3″- dimethylbutanoyl)-13-O-dodecanoylingenol (1) and 3-O-(2″,3″- dimethylbutanoyl)-13-O-decanoylingenol (2) isolated from Euphorbia kansui, showed a pronounced antinematodal activity against the nematode Bursaphelenchus xylophilus at the same minimum effective dose (MED) of 5 μg per cotton ball and still displayed antinematodal activity at a dose of 2.5 μg per cotton ball. Compounds 3-6 were obtained, and the structure of the new compound 6 was elucidated based on 1D-and 2D-NMR analyses and physicochemical data. Preliminary structure-biological activity relationships of ingenane-type compounds were deduced.",

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AU - Shi, Jianxiao

AU - Li, Zhixuan

AU - Nitoda, Teruhiko

AU - Izumi, Minoru

AU - Kanzaki, Hiroshi

AU - Baba, Naomichi

AU - Kawazu, Kazuyoshi

AU - Nakajima, Shuhei

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AB - Under the bioassay-guided method, two diterpenes, 3-O-(2″,3″- dimethylbutanoyl)-13-O-dodecanoylingenol (1) and 3-O-(2″,3″- dimethylbutanoyl)-13-O-decanoylingenol (2) isolated from Euphorbia kansui, showed a pronounced antinematodal activity against the nematode Bursaphelenchus xylophilus at the same minimum effective dose (MED) of 5 μg per cotton ball and still displayed antinematodal activity at a dose of 2.5 μg per cotton ball. Compounds 3-6 were obtained, and the structure of the new compound 6 was elucidated based on 1D-and 2D-NMR analyses and physicochemical data. Preliminary structure-biological activity relationships of ingenane-type compounds were deduced.

KW - Antinematodal

KW - Bursaphelenchus xylophilus

KW - Euphorbia kansui

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Antinematodal activities of ingenane diterpenes from Euphorbia kansui and their derivatives against the pine wood nematode (Bursaphelenchus xylophilus)

Abstract

Keywords

ASJC Scopus subject areas

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