TY - JOUR
T1 - Antinematodal activities of ingenane diterpenes from Euphorbia kansui and their derivatives against the pine wood nematode (Bursaphelenchus xylophilus)
AU - Shi, Jianxiao
AU - Li, Zhixuan
AU - Nitoda, Teruhiko
AU - Izumi, Minoru
AU - Kanzaki, Hiroshi
AU - Baba, Naomichi
AU - Kawazu, Kazuyoshi
AU - Nakajima, Shuhei
PY - 2008
Y1 - 2008
N2 - Under the bioassay-guided method, two diterpenes, 3-O-(2″,3″- dimethylbutanoyl)-13-O-dodecanoylingenol (1) and 3-O-(2″,3″- dimethylbutanoyl)-13-O-decanoylingenol (2) isolated from Euphorbia kansui, showed a pronounced antinematodal activity against the nematode Bursaphelenchus xylophilus at the same minimum effective dose (MED) of 5 μg per cotton ball and still displayed antinematodal activity at a dose of 2.5 μg per cotton ball. Compounds 3-6 were obtained, and the structure of the new compound 6 was elucidated based on 1D-and 2D-NMR analyses and physicochemical data. Preliminary structure-biological activity relationships of ingenane-type compounds were deduced.
AB - Under the bioassay-guided method, two diterpenes, 3-O-(2″,3″- dimethylbutanoyl)-13-O-dodecanoylingenol (1) and 3-O-(2″,3″- dimethylbutanoyl)-13-O-decanoylingenol (2) isolated from Euphorbia kansui, showed a pronounced antinematodal activity against the nematode Bursaphelenchus xylophilus at the same minimum effective dose (MED) of 5 μg per cotton ball and still displayed antinematodal activity at a dose of 2.5 μg per cotton ball. Compounds 3-6 were obtained, and the structure of the new compound 6 was elucidated based on 1D-and 2D-NMR analyses and physicochemical data. Preliminary structure-biological activity relationships of ingenane-type compounds were deduced.
KW - Antinematodal
KW - Bursaphelenchus xylophilus
KW - Euphorbia kansui
KW - Ingenane diterpenes
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U2 - 10.1515/znc-2008-1-211
DO - 10.1515/znc-2008-1-211
M3 - Article
C2 - 18386489
AN - SCOPUS:40549130710
VL - 63
SP - 59
EP - 65
JO - Zeitschrift fur Naturforschung. Teil C: Biochemie, Biophysik, Biologie, Virologie
JF - Zeitschrift fur Naturforschung. Teil C: Biochemie, Biophysik, Biologie, Virologie
SN - 0939-5075
IS - 1-2
ER -