Antimycin A-like molecules inhibit cyclic electron transport around photosystem I in ruptured chloroplasts

Yoshichika Taira, Yuki Okegawa, Kazuhiko Sugimoto, Masato Abe, Hideto Miyoshi, Toshiharu Shikanai

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Antimycin A3 (AA) is used as an inhibitor of cyclic electron transport around photosystem I. However, the high concentrations of AA that are needed for inhibition have secondary effects, even in chloroplasts. Here, we screened for chemicals that inhibited ferredoxin-dependent plastoquinone reduction in ruptured chloroplasts at lower concentrations than those required for AA. We identified two AA-like compounds: AAL1 and AAL2. AAL1 likely shares an inhibitory site with AA, most probably in the PGR5-PGRL1 protein complex, and enhances O2 evolution in photosystem II, most likely via an uncoupler-like effect. AAL1 and AAL2 are unlikely to penetrate intact leaves. In ruptured chloroplasts, AALs are superior to AA as inhibitors of cyclic electron transport.

Original languageEnglish
Pages (from-to)406-410
Number of pages5
JournalFEBS Open Bio
Volume3
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • Antimycin A
  • Chloroplast
  • Cyclic electron transport
  • PGR5
  • Photosynthesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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