Antimicrobial susceptibility of clinical isolates of aerobic gram-negative bacteria in 2006

Isamu Yoshida, Takahiro Yamaguchi, Yoshihisa Itoh, Mineji Tachibana, Choichiro Takahashi, Mitsuo Kaku, Keiji Kanemitsu, Masahiko Okada, Yoshinori Horikawa, Joji Shiotani, Hiroyoshi Kino, Yuka Ono, Hisashi Baba, Shuji Matsuo, Seishi Asari, Masahiro Toyokawa, Kimiko Matsuoka, Nobuchika Kusano, Motoko Nose, Mitsuharu MuraseHitoshi Miyamoto, Tetsunori Saikawa, Kazufumi Hiramatsu, Shigeru Kohno, Katsunori Yanagihara, Nobuhisa Yamane, Isamu Nakasone, Hideki Maki, Yoshinori Yamano

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11 Citations (Scopus)

Abstract

We determined MICs of antibacterial agents against 1280 clinical strains of aerobic Gram-negative bacteria (19 genus or species) isolated at 16 Japanese facilities in 2006. MICs were determined using mostly broth microdilution method and antibacterial activity was assessed. Strains producing extended-spectrum β-lactamases (ESBL) accounted for 3.7% of Escherichia coli, 2.7% of Klebsiella spp., and 11.4% of Proteus spp. Notably, 18.8% of Proteus mirabilis was found to produce ESBL higher than 16.7% in 2004. This result was higher extremely than other species. Among Haemophilus influenzae, only 1.2% produced β-lactamase and 62.8% that increased compared with 57.7% in 2004, were β-lactamase-negative ampicillin-resistant strains when classified by penicillin-binding protein 3 mutation. Although few antibacterial agents against Pseudomonas aeruginosa have potent activity, only three agents - doripenem, ciprofloxacin, and tobramycin - showed an MIC90 of 4 μg/mL. Of all P. aeruginosa strains, 5.7% were resistant to six or more agents of nine antipseudomonal agents, a decrease compared to 8.7% in 2004. Against other glucose-non-fermentative Gram-negative bacteria, the activity of most antibacterial agents was similar to that in 2004.

Original languageEnglish
Pages (from-to)457-479
Number of pages23
JournalJapanese Journal of Antibiotics
Volume63
Issue number6
Publication statusPublished - Dec 2010

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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    Yoshida, I., Yamaguchi, T., Itoh, Y., Tachibana, M., Takahashi, C., Kaku, M., Kanemitsu, K., Okada, M., Horikawa, Y., Shiotani, J., Kino, H., Ono, Y., Baba, H., Matsuo, S., Asari, S., Toyokawa, M., Matsuoka, K., Kusano, N., Nose, M., ... Yamano, Y. (2010). Antimicrobial susceptibility of clinical isolates of aerobic gram-negative bacteria in 2006. Japanese Journal of Antibiotics, 63(6), 457-479.