Antimicrobial susceptibility of clinical isolates of aerobic Gram-positive cocci and anaerobic bacteria in 2004

Takaji Fujimura, Isamu Yoshida, Yoshihisa Itoh, Mineji Tachibana, Mitsuo Kaku, Keiji Kanemitsu, Choichiro Takahashi, Joji Shiotani, Yuka Ono, Hisashi Baba, Shuji Matsuo, Seishi Asari, Kimiko Matsuoka, Nobuchika Kusano, Motoko Nose, Tetsunori Saikawa, Kazufumi Hiramatsu, Shigeru Kohno, Yoichi Hirakata, Nobuhisa YamaneIsamu Nakasone, Yoshinori Yamano

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The activity of antibacterial agents against aerobic Gram-positive cocci (28 species, 1,020 strains) and anaerobic bacteria (21 species, 170 strains) isolated from clinical specimens in 2004 at 16 clinical facilities in Japan were studied using either broth microdilution or agar dilution method. The ratio of methicillin-resistant strains among Staphylococcus aureus was 63.1% and Staphylococcus epidermidis 84.2%, suggesting that resistant strains were isolated at high frequency. Vancomycin(VCM), linezolid(LZD), and quinupristin/dalfopristin (QPR/DPR) had good antibacterial activity against methicillin-resistant S. aureus and methicillin-resistant S. epidermidis, with MIC90s of ≤2 μg/mL. The ratio of penicillin(PC) intermediate and resistant strains classified by mutations of PC-binding proteins among Streptococcus pneumoniae was 86.5%. Cefpirome, ceftriaxone, carbapenem antibiotics, VCM, and teicoplanin had MIC90s of ≤1 μg/mL against PC-intermediate and resistant S. pneumoniae strains. VCM and teicoplanin also showed good antibacterial activity against Enterococcus faecalis and Enterococcus faecium with MIC90s of ≤2 μg/mL, and no resistant strains were detected. Of E. faecium strains, 7.8% showed intermediate and 23.4% resistant to LZD or QPR/DPR. Among anaerobes, carbapenems showed good activity against Peptococcaceae, Bacteroides spp., and Prevotella spp. The susceptibility of Bacteroides spp. other than Bacteroides fragilis to these antibiotics, however, appeared to be lowered, necessitating well-focused surveillance studies.

Original languageEnglish
Pages (from-to)543-561
Number of pages19
JournalJapanese Journal of Chemotherapy
Volume56
Issue number5
Publication statusPublished - Sep 2008

Fingerprint

Linezolid
Gram-Positive Cocci
Aerobic Bacteria
Anaerobic Bacteria
Gram-Positive Bacteria
Vancomycin
Teicoplanin
Enterococcus faecium
Bacteroides
Methicillin Resistance
Carbapenems
cefpirome
Staphylococcus epidermidis
Streptococcus pneumoniae
Peptococcaceae
Penicillins
Prevotella
Anti-Bacterial Agents
Penicillin-Binding Proteins
Bacteroides fragilis

Keywords

  • Anaerobe
  • Clinical isolate
  • Drug susceptibility
  • Gram-positive cocci
  • Surveillance

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Fujimura, T., Yoshida, I., Itoh, Y., Tachibana, M., Kaku, M., Kanemitsu, K., ... Yamano, Y. (2008). Antimicrobial susceptibility of clinical isolates of aerobic Gram-positive cocci and anaerobic bacteria in 2004. Japanese Journal of Chemotherapy, 56(5), 543-561.

Antimicrobial susceptibility of clinical isolates of aerobic Gram-positive cocci and anaerobic bacteria in 2004. / Fujimura, Takaji; Yoshida, Isamu; Itoh, Yoshihisa; Tachibana, Mineji; Kaku, Mitsuo; Kanemitsu, Keiji; Takahashi, Choichiro; Shiotani, Joji; Ono, Yuka; Baba, Hisashi; Matsuo, Shuji; Asari, Seishi; Matsuoka, Kimiko; Kusano, Nobuchika; Nose, Motoko; Saikawa, Tetsunori; Hiramatsu, Kazufumi; Kohno, Shigeru; Hirakata, Yoichi; Yamane, Nobuhisa; Nakasone, Isamu; Yamano, Yoshinori.

In: Japanese Journal of Chemotherapy, Vol. 56, No. 5, 09.2008, p. 543-561.

Research output: Contribution to journalArticle

Fujimura, T, Yoshida, I, Itoh, Y, Tachibana, M, Kaku, M, Kanemitsu, K, Takahashi, C, Shiotani, J, Ono, Y, Baba, H, Matsuo, S, Asari, S, Matsuoka, K, Kusano, N, Nose, M, Saikawa, T, Hiramatsu, K, Kohno, S, Hirakata, Y, Yamane, N, Nakasone, I & Yamano, Y 2008, 'Antimicrobial susceptibility of clinical isolates of aerobic Gram-positive cocci and anaerobic bacteria in 2004', Japanese Journal of Chemotherapy, vol. 56, no. 5, pp. 543-561.
Fujimura T, Yoshida I, Itoh Y, Tachibana M, Kaku M, Kanemitsu K et al. Antimicrobial susceptibility of clinical isolates of aerobic Gram-positive cocci and anaerobic bacteria in 2004. Japanese Journal of Chemotherapy. 2008 Sep;56(5):543-561.
Fujimura, Takaji ; Yoshida, Isamu ; Itoh, Yoshihisa ; Tachibana, Mineji ; Kaku, Mitsuo ; Kanemitsu, Keiji ; Takahashi, Choichiro ; Shiotani, Joji ; Ono, Yuka ; Baba, Hisashi ; Matsuo, Shuji ; Asari, Seishi ; Matsuoka, Kimiko ; Kusano, Nobuchika ; Nose, Motoko ; Saikawa, Tetsunori ; Hiramatsu, Kazufumi ; Kohno, Shigeru ; Hirakata, Yoichi ; Yamane, Nobuhisa ; Nakasone, Isamu ; Yamano, Yoshinori. / Antimicrobial susceptibility of clinical isolates of aerobic Gram-positive cocci and anaerobic bacteria in 2004. In: Japanese Journal of Chemotherapy. 2008 ; Vol. 56, No. 5. pp. 543-561.
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abstract = "The activity of antibacterial agents against aerobic Gram-positive cocci (28 species, 1,020 strains) and anaerobic bacteria (21 species, 170 strains) isolated from clinical specimens in 2004 at 16 clinical facilities in Japan were studied using either broth microdilution or agar dilution method. The ratio of methicillin-resistant strains among Staphylococcus aureus was 63.1{\%} and Staphylococcus epidermidis 84.2{\%}, suggesting that resistant strains were isolated at high frequency. Vancomycin(VCM), linezolid(LZD), and quinupristin/dalfopristin (QPR/DPR) had good antibacterial activity against methicillin-resistant S. aureus and methicillin-resistant S. epidermidis, with MIC90s of ≤2 μg/mL. The ratio of penicillin(PC) intermediate and resistant strains classified by mutations of PC-binding proteins among Streptococcus pneumoniae was 86.5{\%}. Cefpirome, ceftriaxone, carbapenem antibiotics, VCM, and teicoplanin had MIC90s of ≤1 μg/mL against PC-intermediate and resistant S. pneumoniae strains. VCM and teicoplanin also showed good antibacterial activity against Enterococcus faecalis and Enterococcus faecium with MIC90s of ≤2 μg/mL, and no resistant strains were detected. Of E. faecium strains, 7.8{\%} showed intermediate and 23.4{\%} resistant to LZD or QPR/DPR. Among anaerobes, carbapenems showed good activity against Peptococcaceae, Bacteroides spp., and Prevotella spp. The susceptibility of Bacteroides spp. other than Bacteroides fragilis to these antibiotics, however, appeared to be lowered, necessitating well-focused surveillance studies.",
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AU - Takahashi, Choichiro

AU - Shiotani, Joji

AU - Ono, Yuka

AU - Baba, Hisashi

AU - Matsuo, Shuji

AU - Asari, Seishi

AU - Matsuoka, Kimiko

AU - Kusano, Nobuchika

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AU - Saikawa, Tetsunori

AU - Hiramatsu, Kazufumi

AU - Kohno, Shigeru

AU - Hirakata, Yoichi

AU - Yamane, Nobuhisa

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