TY - JOUR
T1 - Antimicrobial susceptibility of clinical isolates of aerobic gram-positive cocci and anaerobic bacteria in 2006
AU - Yamaguchi, Takahiro
AU - Yoshida, Isamu
AU - Itoh, Yoshihisa
AU - Tachibana, Mineji
AU - Takahashi, Choichiro
AU - Kaku, Mitsuo
AU - Kanemitsu, Keiji
AU - Okada, Masahiko
AU - Horikawa, Yoshinori
AU - Shiotani, Joji
AU - Kino, Hiroyoshi
AU - Ono, Yuka
AU - Baba, Hisashi
AU - Matsuo, Shuji
AU - Asari, Seishi
AU - Toyokawa, Masahiro
AU - Matsuoka, Kimiko
AU - Kusano, Nobuchika
AU - Nose, Motoko
AU - Murase, Mitsuharu
AU - Miyamoto, Hitoshi
AU - Saikawa, Tetsunori
AU - Hiramatsu, Kazufumi
AU - Kohno, Shigeru
AU - Yanagihara, Katsunori
AU - Yamane, Nobuhisa
AU - Nakasone, Isamu
AU - Maki, Hideki
AU - Yamano, Yoshinori
PY - 2010/12
Y1 - 2010/12
N2 - The activity of antibacterial agents against aerobic Gram-positive cocci (26 species, 1022 strains) and anaerobic bacteria (23 species, 184 strains) isolated from clinical specimens in 2006 at 16 clinical facilities in Japan were studied using either broth microdilution or agar dilution method. The ratio of methicillin-resistant strains among Staphylococcus aureus and Staphylococcus epidermidis was 53.0% and 65.8%, suggesting that resistant strains were isolated at high frequency. Vancomycin (VCM) and quinupristin/dalfopristin (QPR/DPR) had good antibacterial activity against methicillin-resistant S. aureus and methicillin-resistant S. epidermidis, with MIC90s of ≤2 μg/mL. The ratio of penicillin (PC) intermediate and resistant strains classified by mutations of PC-binding proteins among Streptococcus pneumoniae was 87.6%. Ceftriaxone, cefpirome, cefepime, carbapenem antibiotics, VCM, teicoplanin, linezolid(LZD) and QPR/DPR had MIC90s of ≤1 μg/mL against PC-intermediate and resistant S. pneumoniae strains. Against all strains of Enterococcus faecalis and Enterococcus faecium, the MICs of VCM and TEIC were under 2 μg/mL, and no resistant strain was detected, suggesting that these agents had excellent activities against these species. 10.9% of E. faecalis strains or 3.5% of E. faecium strains showed intermediate or resistant to LZD. 24.4% of E. faecium strains showed intermediate or resistant to QPR/DPR. Against all strains of Clostridium difficile, the MIC of VCM were under 1 μg/mL, suggesting that VCM had excellent activity against C. difficile. Carbapenems showed good activity against Peptococcaceae, Bacteroides spp., and Prevotella spp. However since several strains of Bacteroides fragilis showed resistant to carbapenems and the susceptibility of this species should be well-focused in the future.
AB - The activity of antibacterial agents against aerobic Gram-positive cocci (26 species, 1022 strains) and anaerobic bacteria (23 species, 184 strains) isolated from clinical specimens in 2006 at 16 clinical facilities in Japan were studied using either broth microdilution or agar dilution method. The ratio of methicillin-resistant strains among Staphylococcus aureus and Staphylococcus epidermidis was 53.0% and 65.8%, suggesting that resistant strains were isolated at high frequency. Vancomycin (VCM) and quinupristin/dalfopristin (QPR/DPR) had good antibacterial activity against methicillin-resistant S. aureus and methicillin-resistant S. epidermidis, with MIC90s of ≤2 μg/mL. The ratio of penicillin (PC) intermediate and resistant strains classified by mutations of PC-binding proteins among Streptococcus pneumoniae was 87.6%. Ceftriaxone, cefpirome, cefepime, carbapenem antibiotics, VCM, teicoplanin, linezolid(LZD) and QPR/DPR had MIC90s of ≤1 μg/mL against PC-intermediate and resistant S. pneumoniae strains. Against all strains of Enterococcus faecalis and Enterococcus faecium, the MICs of VCM and TEIC were under 2 μg/mL, and no resistant strain was detected, suggesting that these agents had excellent activities against these species. 10.9% of E. faecalis strains or 3.5% of E. faecium strains showed intermediate or resistant to LZD. 24.4% of E. faecium strains showed intermediate or resistant to QPR/DPR. Against all strains of Clostridium difficile, the MIC of VCM were under 1 μg/mL, suggesting that VCM had excellent activity against C. difficile. Carbapenems showed good activity against Peptococcaceae, Bacteroides spp., and Prevotella spp. However since several strains of Bacteroides fragilis showed resistant to carbapenems and the susceptibility of this species should be well-focused in the future.
UR - http://www.scopus.com/inward/record.url?scp=79551595812&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79551595812&partnerID=8YFLogxK
M3 - Article
C2 - 21425596
AN - SCOPUS:79551595812
SN - 0368-2781
VL - 63
SP - 431
EP - 456
JO - The Journal of antibiotics. Ser. B
JF - The Journal of antibiotics. Ser. B
IS - 6
ER -
