Antimicrobial susceptibility of clinical isolates of aerobic gram-positive cocci and anaerobic bacteria in 2006

Takahiro Yamaguchi, Isamu Yoshida, Yoshihisa Itoh, Mineji Tachibana, Choichiro Takahashi, Mitsuo Kaku, Keiji Kanemitsu, Masahiko Okada, Yoshinori Horikawa, Joji Shiotani, Hiroyoshi Kino, Yuka Ono, Hisashi Baba, Shuji Matsuo, Seishi Asari, Masahiro Toyokawa, Kimiko Matsuoka, Nobuchika Kusano, Motoko Nose, Mitsuharu MuraseHitoshi Miyamoto, Tetsunori Saikawa, Kazufumi Hiramatsu, Shigeru Kohno, Katsunori Yanagihara, Nobuhisa Yamane, Isamu Nakasone, Hideki Maki, Yoshinori Yamano

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The activity of antibacterial agents against aerobic Gram-positive cocci (26 species, 1022 strains) and anaerobic bacteria (23 species, 184 strains) isolated from clinical specimens in 2006 at 16 clinical facilities in Japan were studied using either broth microdilution or agar dilution method. The ratio of methicillin-resistant strains among Staphylococcus aureus and Staphylococcus epidermidis was 53.0% and 65.8%, suggesting that resistant strains were isolated at high frequency. Vancomycin (VCM) and quinupristin/dalfopristin (QPR/DPR) had good antibacterial activity against methicillin-resistant S. aureus and methicillin-resistant S. epidermidis, with MIC90s of ≤2 μg/mL. The ratio of penicillin (PC) intermediate and resistant strains classified by mutations of PC-binding proteins among Streptococcus pneumoniae was 87.6%. Ceftriaxone, cefpirome, cefepime, carbapenem antibiotics, VCM, teicoplanin, linezolid(LZD) and QPR/DPR had MIC90s of ≤1 μg/mL against PC-intermediate and resistant S. pneumoniae strains. Against all strains of Enterococcus faecalis and Enterococcus faecium, the MICs of VCM and TEIC were under 2 μg/mL, and no resistant strain was detected, suggesting that these agents had excellent activities against these species. 10.9% of E. faecalis strains or 3.5% of E. faecium strains showed intermediate or resistant to LZD. 24.4% of E. faecium strains showed intermediate or resistant to QPR/DPR. Against all strains of Clostridium difficile, the MIC of VCM were under 1 μg/mL, suggesting that VCM had excellent activity against C. difficile. Carbapenems showed good activity against Peptococcaceae, Bacteroides spp., and Prevotella spp. However since several strains of Bacteroides fragilis showed resistant to carbapenems and the susceptibility of this species should be well-focused in the future.

Original languageEnglish
Pages (from-to)431-456
Number of pages26
JournalJapanese Journal of Antibiotics
Volume63
Issue number6
Publication statusPublished - Dec 2010

Fingerprint

Gram-Positive Cocci
Aerobic Bacteria
Anaerobic Bacteria
Gram-Positive Bacteria
Vancomycin
Linezolid
Enterococcus faecium
Carbapenems
Methicillin Resistance
cefpirome
Staphylococcus epidermidis
Clostridium difficile
Enterococcus faecalis
Streptococcus pneumoniae
Peptococcaceae
Penicillins
Prevotella
Penicillin-Binding Proteins
Teicoplanin
Bacteroides fragilis

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Microbiology (medical)

Cite this

Yamaguchi, T., Yoshida, I., Itoh, Y., Tachibana, M., Takahashi, C., Kaku, M., ... Yamano, Y. (2010). Antimicrobial susceptibility of clinical isolates of aerobic gram-positive cocci and anaerobic bacteria in 2006. Japanese Journal of Antibiotics, 63(6), 431-456.

Antimicrobial susceptibility of clinical isolates of aerobic gram-positive cocci and anaerobic bacteria in 2006. / Yamaguchi, Takahiro; Yoshida, Isamu; Itoh, Yoshihisa; Tachibana, Mineji; Takahashi, Choichiro; Kaku, Mitsuo; Kanemitsu, Keiji; Okada, Masahiko; Horikawa, Yoshinori; Shiotani, Joji; Kino, Hiroyoshi; Ono, Yuka; Baba, Hisashi; Matsuo, Shuji; Asari, Seishi; Toyokawa, Masahiro; Matsuoka, Kimiko; Kusano, Nobuchika; Nose, Motoko; Murase, Mitsuharu; Miyamoto, Hitoshi; Saikawa, Tetsunori; Hiramatsu, Kazufumi; Kohno, Shigeru; Yanagihara, Katsunori; Yamane, Nobuhisa; Nakasone, Isamu; Maki, Hideki; Yamano, Yoshinori.

In: Japanese Journal of Antibiotics, Vol. 63, No. 6, 12.2010, p. 431-456.

Research output: Contribution to journalArticle

Yamaguchi, T, Yoshida, I, Itoh, Y, Tachibana, M, Takahashi, C, Kaku, M, Kanemitsu, K, Okada, M, Horikawa, Y, Shiotani, J, Kino, H, Ono, Y, Baba, H, Matsuo, S, Asari, S, Toyokawa, M, Matsuoka, K, Kusano, N, Nose, M, Murase, M, Miyamoto, H, Saikawa, T, Hiramatsu, K, Kohno, S, Yanagihara, K, Yamane, N, Nakasone, I, Maki, H & Yamano, Y 2010, 'Antimicrobial susceptibility of clinical isolates of aerobic gram-positive cocci and anaerobic bacteria in 2006', Japanese Journal of Antibiotics, vol. 63, no. 6, pp. 431-456.
Yamaguchi T, Yoshida I, Itoh Y, Tachibana M, Takahashi C, Kaku M et al. Antimicrobial susceptibility of clinical isolates of aerobic gram-positive cocci and anaerobic bacteria in 2006. Japanese Journal of Antibiotics. 2010 Dec;63(6):431-456.
Yamaguchi, Takahiro ; Yoshida, Isamu ; Itoh, Yoshihisa ; Tachibana, Mineji ; Takahashi, Choichiro ; Kaku, Mitsuo ; Kanemitsu, Keiji ; Okada, Masahiko ; Horikawa, Yoshinori ; Shiotani, Joji ; Kino, Hiroyoshi ; Ono, Yuka ; Baba, Hisashi ; Matsuo, Shuji ; Asari, Seishi ; Toyokawa, Masahiro ; Matsuoka, Kimiko ; Kusano, Nobuchika ; Nose, Motoko ; Murase, Mitsuharu ; Miyamoto, Hitoshi ; Saikawa, Tetsunori ; Hiramatsu, Kazufumi ; Kohno, Shigeru ; Yanagihara, Katsunori ; Yamane, Nobuhisa ; Nakasone, Isamu ; Maki, Hideki ; Yamano, Yoshinori. / Antimicrobial susceptibility of clinical isolates of aerobic gram-positive cocci and anaerobic bacteria in 2006. In: Japanese Journal of Antibiotics. 2010 ; Vol. 63, No. 6. pp. 431-456.
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AU - Nose, Motoko

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AU - Miyamoto, Hitoshi

AU - Saikawa, Tetsunori

AU - Hiramatsu, Kazufumi

AU - Kohno, Shigeru

AU - Yanagihara, Katsunori

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AU - Nakasone, Isamu

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