Antimicrobial susceptibility of clinical isolates of aerobic Gram-negative bacteria in 2008

Isamu Yoshida, Takahiro Yamaguchi, Reiko Kudo, Rieko Fuji, Choichiro Takahashi, Reiko Oota, Mitsuo Kaku, Hiroyuki Kunishima, Masahiko Okada, Yoshinori Horikawa, Joji Shiotani, Hiroyoshi Kino, Yuka Ono, Shinichi Fujita, Shuji Matsuo, Hisashi Kono, Seishi Asari, Masahiro Toyokawa, Nobuchika Kusano, Motoko NoseToshinobu Horii, Ayako Tanimoto, Hitoshi Miyamoto, Tetsunori Saikawa, Kazufumi Hiramatsu, Shigeru Kohno, Katsunori Yanagihara, Nobuhisa Yamane, Isamu Nakasone, Hideki Maki, Yoshinori Yamano

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5 Citations (Scopus)

Abstract

We determined MICs of antibacterial agents against 1145 clinical strains of aerobic Gram-negative bacteria (22 species) isolated at 16 Japanese facilities in 2008. MICs were determined using mostly broth microdilution method and antibacterial activity was assessed. Strains producing extended-spectrum β-lactamases (ESBL) accounted for 3.8% of Escherichia coli, 2.6% of Klebsiella pneumoniae, 6.8% of Klebsiella oxytoca, 5.5% of Proteus mirabilis and 1.8% of Proteus vulgaris. ESBL produced strains were 6.8% at K. oxytoca that increased compared with 3.2% and 5.5% at P. mirabilis that decreased compared with 18.8% in 2006. Among Haemophilus influenzae, 61.7% that decreased compared with 67.7% in 2006, equaled 58.7% in 2004, were strains when classified by penicillin-binding protein 3 mutation. Against Pseudomonas aeruginosa, the activity of most antibacterial agents was similar to that in 2006. Although two antibacterial agents that tobramycin showed an MIC 90 of 1μg/mL and doripenem showed an MIC 90 of 4μg/mL against P. aeruginosa have potent activity. Of all P. aeruginosa strains, 4.3% were resistant to six agents of nine antipseudomonal agents, that decreased compared to 12.2% in 2004 and 5.7% in 2006. Against other glucose-non-fermentative Gram-negative rods, the activity of most antibacterial agents was similar to that in 2006.

Original languageEnglish
Pages (from-to)73-96
Number of pages24
JournalJapanese Journal of Antibiotics
Volume65
Issue number1
Publication statusPublished - Feb 2012

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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  • Cite this

    Yoshida, I., Yamaguchi, T., Kudo, R., Fuji, R., Takahashi, C., Oota, R., Kaku, M., Kunishima, H., Okada, M., Horikawa, Y., Shiotani, J., Kino, H., Ono, Y., Fujita, S., Matsuo, S., Kono, H., Asari, S., Toyokawa, M., Kusano, N., ... Yamano, Y. (2012). Antimicrobial susceptibility of clinical isolates of aerobic Gram-negative bacteria in 2008. Japanese Journal of Antibiotics, 65(1), 73-96.