Antimicrobial periodontal treatment decreases serum C-reactive protein, tumor necrosis factor-alpha, but not adiponectin levels in patients with chronic periodontitis

Yoshihiro Iwamoto, Fusanori Nishimura, Yoshihiko Soga, Kazu Takeuchi, Mikinao Kurihara, Shogo Takashiba, Yoji Murayama

Research output: Contribution to journalArticle

120 Citations (Scopus)


Background: Elevated levels of C-reactive protein (CRP) and decreased plasma adiponectin are associated with increased risk of atherosclerosis. Furthermore, recent observations suggested that adiponectin and tumor necrosis factor-α (TNF-α) suppressed each other's production. Since periodontal disease has been suggested to act as a risk factor for atherosclerosis, we examined the effects of antimicrobial periodontal treatment on CRP, adiponectin, and TNF-α levels. Methods: Fifteen chronic periodontitis patients with various systemic conditions at high risk for atherosclerosis were enrolled in the study. Patients were non-surgically treated with topical application of antibiotics and mechanical debridement of calculus once a week for 1 month. Before and after therapy, CRP, adiponectin, and TNF-α levels were measured. Results: Both CRP and TNF-α levels were significantly decreased after treatment (P

Original languageEnglish
Pages (from-to)1231-1236
Number of pages6
JournalJournal of Periodontology
Issue number8
Publication statusPublished - Aug 1 2003



  • Adiponectin
  • Atherosclerosis
  • Diabetes mellitus, non-insulin dependent
  • Periodontal diseases/complications
  • Proteins, C-reactive
  • Risk factors
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Dentistry(all)

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