Antimicrobial periodontal treatment decreases serum C-reactive protein, tumor necrosis factor-alpha, but not adiponectin levels in patients with chronic periodontitis

Yoshihiro Iwamoto, Fusanori Nishimura, Yoshihiko Soga, Kazu Takeuchi, Mikinao Kurihara, Shogo Takashiba, Yoji Murayama

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Background: Elevated levels of C-reactive protein (CRP) and decreased plasma adiponectin are associated with increased risk of atherosclerosis. Furthermore, recent observations suggested that adiponectin and tumor necrosis factor-α (TNF-α) suppressed each other's production. Since periodontal disease has been suggested to act as a risk factor for atherosclerosis, we examined the effects of antimicrobial periodontal treatment on CRP, adiponectin, and TNF-α levels. Methods: Fifteen chronic periodontitis patients with various systemic conditions at high risk for atherosclerosis were enrolled in the study. Patients were non-surgically treated with topical application of antibiotics and mechanical debridement of calculus once a week for 1 month. Before and after therapy, CRP, adiponectin, and TNF-α levels were measured. Results: Both CRP and TNF-α levels were significantly decreased after treatment (P <0.01 and P <0.03, respectively), while adiponectin levels did not change significantly. Conclusions: Periodontal treatment is effective in reducing CRP and TNF-α, while adiponectin does not appear to be influenced by periodontal treatment. Elevated levels of CRP and TNF-α may be associated with increased risk for future development of atherosclerosis in periodontitis patients.

Original languageEnglish
Pages (from-to)1231-1236
Number of pages6
JournalJournal of periodontology
Volume74
Issue number8
DOIs
Publication statusPublished - Aug 1 2003

Keywords

  • Adiponectin
  • Atherosclerosis
  • Diabetes mellitus, non-insulin dependent
  • Periodontal diseases/complications
  • Proteins, C-reactive
  • Risk factors
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Periodontics

Fingerprint Dive into the research topics of 'Antimicrobial periodontal treatment decreases serum C-reactive protein, tumor necrosis factor-alpha, but not adiponectin levels in patients with chronic periodontitis'. Together they form a unique fingerprint.

  • Cite this